Effect of Timi3 Ultrasound on Myocardial Blow Flow in the Hibernating Myocardium

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

EARLY_PHASE1

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-04-30

Study Completion Date

2010-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to evaluate whether the use application of low frequency ultrasound, administered by the Timi3 ultrasound device, increases myocardial blood flow to the heart, in subjects with reduced myocardial blood flow at rest (hibernating myocardium). The primary endpoint of the trial is to assess the increase in myocardial blood flow from baseline to post Timi3 Ultrasound treatment in a hypoperfused region of myocardium. Positron emission tomography (PET) imaging will be used to noninvasively evaluate cardiac blood flow. The hypothesis is that ultrasound increases blood flow in hibernating myocardium.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease

NCT04732091

Acute Myocardial Infarction Unstable Angina

RECRUITING

Efficacy of Early Home-based Cardiac Rehabilitation Program for Patients After Acute Myocardial Infarction

NCT02584192

Acute Myocardial Infarction

COMPLETED NA

T-Wave Alternans in Patients With Suspected Acute Coronary Syndrome

NCT01137513

Chest Pain Acute Coronary Syndrome Acute Myocardial Infarction

COMPLETED

Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI)

NCT02818127

Coronary Angiography Coronary Artery Disease Coronary Artery Ectasia +2 more

UNKNOWN NA

Sonazoid in Myocardial Perfusion Imaging

NCT05637333

Diagnostic Imaging Myocardial Ischemia

WITHDRAWN

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Myocardial Ischemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Timi3 Transthoracic ultrasound

Low frequency ultrasound over the chest using Timi3 ultrasound device

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* \>/= 18 years
* Must have reversible resting ischemia, resting non-reversible blood flow defect, or stress-induced ischemia.
* Females with childbearing potential must not be pregnant at the time of the study
* Must provide written informed consent

Exclusion Criteria

* Unable or unwilling to cooperate with study procedures
* Currently enrolled in another clinical study for which the follow-up period is not complete

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No