Closure Of Patent Ductus Arteriosus With the AMPLATZER Duct Occluder the AMPLATZER® Duct Occluder

NCT ID: NCT00583596

Last Updated: 2023-06-29

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

436 participants

Study Classification

INTERVENTIONAL

Study Start Date

1999-10-31

Study Completion Date

2009-02-28

Brief Summary

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AGA-004 - The objective of the study is to determine safety, effectiveness and clinical utility of the AMPLATZER Duct Occluder in patients with patent ductus arteriosus. AGA-007 - The objective of this study is to evaluate the long term safety and effectiveness issues that may not have have been adequately addressed during AGA-004.

Detailed Description

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Conditions

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Patent Ductus Arteriosus (PDA)

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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implant to close PDA

Group Type EXPERIMENTAL

Device closure with AMPLATZER Duct Occluder

Intervention Type DEVICE

Device closure with AMPLATZER Duct Occluder

Objective Performance Criteria

Intervention Type OTHER

Compare results of device closure to objective performance criteria

Interventions

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Device closure with AMPLATZER Duct Occluder

Device closure with AMPLATZER Duct Occluder

Intervention Type DEVICE

Objective Performance Criteria

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Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with a demonstrated patent ductus arteriosus
* Body weight \> 5 Kilograms

Exclusion Criteria

* Pulmonary vascular resistance above 8 Woods units or a Rp/Rs \>0.4.
* Additional cardiac or non-cardiac abnormality that can reasonably be expected to significantly affect the patient's health adversely in the next two years, i.e.: cancer, Eisenmenger's syndrome, other serious congenital heart disease.
* Pelvic vein or inferior vena cava thrombosis
* Sepsis (local/generalized) or any type of infection that cannot be successfully treated prior to device placement.
* History of repeated pulmonary infection
* Demonstrated intracardiac thrombi on echocardiography • Inability to obtain informed consent
Minimum Eligible Age

6 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott Medical Devices

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Alabama

Birmingham, Alabama, United States

Site Status

Children's Hospital

San Diego, California, United States

Site Status

Children's Hospital

Denver, Colorado, United States

Site Status

Children's National Medical Center

Washington D.C., District of Columbia, United States

Site Status

University of Florida

Gainesville, Florida, United States

Site Status

Arnold Palmer Hospital

Orlando, Florida, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Indiana University School of Medicine

Indianapolis, Indiana, United States

Site Status

Louisana State University Medical Center

New Orleans, Louisiana, United States

Site Status

New England Medical Center

Boston, Massachusetts, United States

Site Status

University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

University of Mississippi Medical Center

Jackson, Mississippi, United States

Site Status

Washington University Medical Center

St Louis, Missouri, United States

Site Status

Children's Hospital UN/CU)

Omaha, Nebraska, United States

Site Status

Columbia University

New York, New York, United States

Site Status

Childrens Hospital

Rochester, New York, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

Medical University of South Carolina

Charleston, South Carolina, United States

Site Status

University of Texas

Dallas, Texas, United States

Site Status

Cook Children's Heart Center

Fort Worth, Texas, United States

Site Status

Children's Hospital of the King's Daughters

Norfolk, Virginia, United States

Site Status

University of Washington Medical Center

Seattle, Washington, United States

Site Status

Children's Hospital of Wisconsin

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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G980103

Identifier Type: -

Identifier Source: secondary_id

AGA-004

Identifier Type: -

Identifier Source: org_study_id

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