Urinary Biomarkers as Predictors on Renal Function in Congenital Hydronephrosis
NCT ID: NCT00568724
Last Updated: 2012-09-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2007-11-30
2012-01-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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1
Children referred to surgical treatment of congenital hydronephrosis
No interventions assigned to this group
2
15 age- and sex-matched controls
No interventions assigned to this group
Children with healthy pelvic tissue
Children referred to nephrectomy due to nephrotic syndrome
No interventions assigned to this group
Adults with healthy pelvic tissue
Adults referred to nephrectomy due to another cause than hydronephrosis
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Declining function of the hydronephrotic kidney more than 5 %, and to less than 40 % of the total renal function OR ipsilateral flank pain.
Exclusion Criteria
* Previous operation in the urinary system except operation for phimosis and other deformations of the external genital organs.
* Deformations in the lower part of the ureter, bladder and urethra. Urinary stones. Reflux. Urinary tract infections \< 6 months.
* Neurogenic bladder dysfunction.
* GFR \< 40 % standardized to age.
* Non-compliance. Linguistic difficulties.
3 Months
15 Years
ALL
Yes
Sponsors
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Aarhus University Hospital
OTHER
University of Aarhus
OTHER
Responsible Party
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Principal Investigators
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Troels M Jørgensen, Professor, MD
Role: PRINCIPAL_INVESTIGATOR
Department of Urology, Aarhus University Hospital Skejby
Locations
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Institute of Clinical Medicine, University of Aarhus
Aarhus, , Denmark
Countries
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References
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Madsen MG, Norregaard R, Palmfeldt J, Olsen LH, Frokiaer J, Jorgensen TM. Urinary NGAL, cystatin C, beta2-microglobulin, and osteopontin significance in hydronephrotic children. Pediatr Nephrol. 2012 Nov;27(11):2099-2106. doi: 10.1007/s00467-012-2217-6. Epub 2012 Jun 19.
Other Identifiers
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MGM-01
Identifier Type: -
Identifier Source: org_study_id