Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
237 participants
OBSERVATIONAL
2007-12-31
2010-12-31
Brief Summary
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Detailed Description
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Our ability to improve outcomes in children and adults with AKI has been hampered by the inability to recognize AKI early in the disease process. Thus, the work on early non-invasive biomarkers of renal injury has brought great optimism to the field of AKI. Serum and urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), urinary interleukin 18 (IL-18) others are markedly elevated several hours after AKI as opposed to serum creatinine which takes days to rise after the inciting event. Early non-invasive biomarkers of AKI have not been tested in premature infants.
Inclusion criteria - infants (birthweight 500-1500g) be asked to participate in the study. • Exclusion criteria - Infants with prenatal renal ultrasound diagnosis of severe hydronephrosis or other known renal abnormalities will be excluded
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Observation
Premature infants in the NICU; 500-1500g birthweight, \>=25 weeks gestation
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* \>=25 weeks gestation
Exclusion Criteria
* infants with severe congenital abnormalities
1 Minute
ALL
No
Sponsors
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National Kidney Foundation, United States
OTHER
University of Alabama at Birmingham
OTHER
Responsible Party
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David Askenazi
Principal Investigator
Locations
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UAB
Birmingham, Alabama, United States
Countries
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References
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Koralkar R, Ambalavanan N, Levitan EB, McGwin G, Goldstein S, Askenazi D. Acute kidney injury reduces survival in very low birth weight infants. Pediatr Res. 2011 Apr;69(4):354-8. doi: 10.1203/PDR.0b013e31820b95ca.
Other Identifiers
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X070926014
Identifier Type: -
Identifier Source: org_study_id
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