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Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women

NCT ID: NCT00520858

Last Updated: 2008-04-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

145 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-09-30

Brief Summary

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The prevalence of abdominal obesity in the elderly is increasing at alarming rates and thus, requires immediate attention. By comparison to younger adults, obesity reduction in the elderly presents a unique challenge and requires an innovative approach. We propose a novel approach to investigate the effects of different exercise types as independent treatment strategies for the reduction of obesity and related health risk factors in older men and women. We propose that exercise without caloric restriction will be associated with modest weight loss (3-5%), that in turn will be associated with significant reduction in abdominal obesity, insulin resistance, and a corresponding increase in skeletal muscle mass and function. We will determine the separate effects of resistance and aerobic exercise on these primary outcome variables, and, whether a treatment strategy that combines the two is optimal.

Detailed Description

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Conditions

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Abdominal Obesity

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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C

Group Type NO_INTERVENTION

No interventions assigned to this group

RE

Resistance Exercise

Group Type ACTIVE_COMPARATOR

Resistance Exercise (RE)

Intervention Type OTHER

AE

Aerobic Exercise

Group Type ACTIVE_COMPARATOR

Aerobic Exercise (AE)

Intervention Type OTHER

RAE

Resistance and Aerobic

Group Type ACTIVE_COMPARATOR

Resistance and Aerobic Exercise (RAE)

Intervention Type OTHER

Interventions

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Resistance Exercise (RE)

Intervention Type OTHER

Aerobic Exercise (AE)

Intervention Type OTHER

Resistance and Aerobic Exercise (RAE)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women between 65 and 80 years of age.
* Men and women are self-sufficient, sedentary, abdominally obese (BMI between 27 and 34.9 kg/m2; waist circumference greater than 88 cm in women and 102 cm in men), weight stable (± 2 kg) for 6 months prior to the beginning of the study, be non-smokers, and not diabetic.
* We will study elderly women who are not taking hormone replacement therapy to create a homogeneous population in whom the effect of exercise on the principal outcome variables can be evaluated with minimal confounding.

Exclusion Criteria

* Smokers and diabetics.
* Women taking hormone replacement therapy.
Minimum Eligible Age

65 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Canadian Institutes of Health Research (CIHR)

OTHER_GOV

Sponsor Role collaborator

Queen's University

OTHER

Sponsor Role lead

Principal Investigators

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Robert Ross

Role: PRINCIPAL_INVESTIGATOR

Queen's University

Locations

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Queen's University

Kingston, Ontario, Canada

Site Status

Countries

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Canada

References

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Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R. Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med. 2009 Jan 26;169(2):122-31. doi: 10.1001/archinternmed.2008.558.

Reference Type DERIVED
PMID: 19171808 (View on PubMed)

Other Identifiers

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Ross2002

Identifier Type: -

Identifier Source: org_study_id