Expression of Steroid Receptors in Endometrium

NCT ID: NCT00436462

Last Updated: 2009-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-12-31

Study Completion Date

2007-12-31

Brief Summary

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Expression of steroid receptors in endometrium during ovarian stimulation.

Detailed Description

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The purpose of this study is to examine in stimulated cycles a) whether there is a difference in expression of steroid receptors in stroma and glands of endometrium between different days during the follicular phase b)whether there are secretory changes detected by endometrium histology before ovulation c)whether there is an association between expression of steroid receptors in endometrium and exposure to oestradiol and progesterone during the follicular phase.

Conditions

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Endometrium

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Treatment by IUI,
* BMI:18-29KGR/M2,
* No previous ovarian surgery,
* Normal hysterosalpingography,
* Estradiol \< 80pg/ml and progesterone \< 1.6ng/ml on day 2 of the cycle

Exclusion Criteria

* Endometriosis,
* Severe male factor
Minimum Eligible Age

20 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Aristotle University Of Thessaloniki

OTHER

Sponsor Role lead

Responsible Party

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Aristotle University of Thessaloniki

Principal Investigators

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Basil C Tarlatzis, MD,PhD

Role: STUDY_DIRECTOR

Unit of Human Reproduction, 1st Department of Obst & Gyn, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece

Locations

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Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital

Thessaloniki, , Greece

Site Status

Countries

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Greece

References

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Kolibianakis E, Bourgain C, Albano C, Osmanagaoglu K, Smitz J, Van Steirteghem A, Devroey P. Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up. Fertil Steril. 2002 Nov;78(5):1025-9. doi: 10.1016/s0015-0282(02)03323-x.

Reference Type BACKGROUND
PMID: 12413988 (View on PubMed)

Papanikolaou EG, Bourgain C, Kolibianakis E, Tournaye H, Devroey P. Steroid receptor expression in late follicular phase endometrium in GnRH antagonist IVF cycles is already altered, indicating initiation of early luteal phase transformation in the absence of secretory changes. Hum Reprod. 2005 Jun;20(6):1541-7. doi: 10.1093/humrep/deh793. Epub 2005 Feb 10.

Reference Type BACKGROUND
PMID: 15705618 (View on PubMed)

Other Identifiers

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UHR-4

Identifier Type: -

Identifier Source: org_study_id

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