Transcranial Magnetic Stimulation and Anti-epileptic Effect: Optimization and Evaluation With Electrophysiology.

NCT ID: NCT00382707

Last Updated: 2025-10-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-05-31

Study Completion Date

2011-08-31

Brief Summary

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Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.

Detailed Description

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Conditions

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Refractory Frontal Lobe Epilepsy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Cryptogenic frontal lobe epilepsy
* Normal cerebral MRI
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Serge CHASSAGNON, MD

Role: STUDY_DIRECTOR

Hôpitaux Universitaires de Strasbourg

Locations

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Département de Neurologie - Hôpital Civil

Strasbourg, , France

Site Status

Institut de Physique Biologique

Strasbourg, , France

Site Status

Countries

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France

Other Identifiers

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3540

Identifier Type: -

Identifier Source: org_study_id

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