Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Brief Summary

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24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.

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Detailed Description

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Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.

Conditions

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Hemorrhoids Fissure in Ano

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Interventions

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Administration of 0,7 mg of atropine

Intervention Type DRUG

Measurement of skin conductance with Pain detector

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients in ASA-group 1-2
* Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
* informed consent
* BMI \<30

Exclusion Criteria

* Patients using any medication known to influence the autonomous nervous system
* Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
* BMI \>30
* Pregnancy

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No