Functional Lipids and Appetite Regulation

NCT ID: NCT00259259

Last Updated: 2009-01-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 22 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-10-31
• Study Completion Date: 2005-12-31

Brief Summary

To evaluate the short-term effects of structured lipids on appetite regulation.

Detailed Description

Background Obesity is a major health problem worldwide, and it is a risk factor for several chronic disorders. Even small changes in energy intake, leading to a positive balance may lead to weight gain over time. Thus, slight modifications in food intake, such as the inclusion of foods that effect energy balance, may prevent weight gain and even facilitate weight loss. Replacing dietary fat with low-calorie fat (LCF), such as modified triglycerides with medium and long chained PUFA.may be an efficient way to reduce body fat.

Bray et al. (2002) has shown a sustained weight loss of ~6 kg over a 9 month period where one-third of a fat-reduced diet (25% fat) was replaced by olestra. This weight loss can not solely be explained by the decreased caloric content of olestra. Thus, inhibition of appetite leading to lower food intake, may be a potential mechanism of the observed weight loss.

A reduced absorption of LCF leaves undigested fatty acids in the middle and lower intestine, which may generate increased feelings of satiety and decrease caloric intake due to regulating peptides and hormones such (CCK, GLP-1, etc.). In addition, intraduodenal fatty acids may also promote distension of the stomach and distension of the intestine, which are well-known gastrointestinal signals controlling mechanisms for food intake.

Taken together, in addition to the acute reduction in caloric intake, LCF may encourage a gastrointestinal hormone response promoting beneficial effects on appetite regulation and energy balance.

Aims To evaluate the short-term effects of LCF on

Primary:

• Appetite sensations after a meal (VAS)
• Postprandiel secretion of appetite regulating hormones
• Ad libitum caloric intake 4,5-h subsequent to a fixed meal

Secondary:

• Palatability of the test meal

Conditions

Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Interventions

SALATRIM

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• healthy males
• Normal weigh, e.i. BMI between 18,5-25 kg/m2
• age 18-40 years

Exclusion Criteria

• donation of blood 3 monhts prior or during the study
• gastrointestinal disorders, diabetes, hypertension, hyperlipidemia, chronic infectious disease
• smoking
• consumption of more than 21 alcoholic drinks/week
• elite athletes
• on mediation
• diet supplements

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Danisco

INDUSTRY

Sponsor Role: collaborator

University of Copenhagen

OTHER

Sponsor Role: lead

Principal Investigators

Arne Astrup, Proffessor

Role: PRINCIPAL_INVESTIGATOR

Department of human nutrition, The Royal Veterinary and Agricultural University

Locations

Department of Human Nutrition, The Royal Veterinary and Agricultural University

Frederiksberg C, Copenhagen, Denmark

Countries

Denmark

Other Identifiers

B218

Identifier Type: -

Identifier Source: secondary_id

(KF) 01 275625

Identifier Type: -

Identifier Source: org_study_id