Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE3
221 participants
INTERVENTIONAL
2002-09-30
2008-03-31
Brief Summary
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Detailed Description
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Patients are randomly assigned to receive 12 sessions (1 session/week for 12 weeks) of either PST or BST. Following treatment, patients are followed for 6 months to determine functional and clinical outcomes. Depression scales, disability scales, and scales that measure problem solving skills are used to assess patients.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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1 Problem Solving Therapy
12 weekly sessions of problem solving therapy (PST)
Problem Solving Therapy
A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
2 Brief Supportive Therapy
12 weekly sessions of brief supportive therapy (BST)
Brief Supportive Therapy
A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.
Interventions
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Problem Solving Therapy
A 12 week cognitive behavioral intervention for depression that teaches patients a structured approach to solving social problems.
Brief Supportive Therapy
A 12 week intervention for depression that focuses on supporting patients attempts to cope with depression.
Eligibility Criteria
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Inclusion Criteria
* Cognitive impairment
* English speaking
Exclusion Criteria
* Dementia
* Acute or severe medical illness
* Current psychotherapy
60 Years
ALL
No
Sponsors
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National Institute of Mental Health (NIMH)
NIH
University of Washington
OTHER
Responsible Party
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Pat Arean
Professor, Psychiatry and Behavioral Sciences
Principal Investigators
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Patricia A. Arean, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California at San Francisco
Locations
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University of California at San Francisco
San Francisco, California, United States
Weill Medical College of Cornell University
White Plains, New York, United States
Countries
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References
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Arean PA, Raue P, Mackin RS, Kanellopoulos D, McCulloch C, Alexopoulos GS. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction. Am J Psychiatry. 2010 Nov;167(11):1391-8. doi: 10.1176/appi.ajp.2010.09091327. Epub 2010 Jun 1.
Alexopoulos GS, Raue PJ, Kiosses DN, Mackin RS, Kanellopoulos D, McCulloch C, Arean PA. Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability. Arch Gen Psychiatry. 2011 Jan;68(1):33-41. doi: 10.1001/archgenpsychiatry.2010.177.
Solomonov N, Kerchner D, Bein O, Lee CE, Diaz JL, Ciarleglio A, Kim S, Sirey JA, Gunning FM, Raue PJ, Banerjee S, Arean PA, Alexopoulos GS. Precision Assignment to Psychosocial Interventions for Late-Life Depression: An Automated Treatment Decision Rule. JAMA Psychiatry. 2025 Sep 17:e252518. doi: 10.1001/jamapsychiatry.2025.2518. Online ahead of print.
Alexopoulos GS, O'Neil R, Banerjee S, Raue PJ, Victoria LW, Bress JN, Pollari C, Arean PA. "Engage" therapy: Prediction of change of late-life major depression. J Affect Disord. 2017 Oct 15;221:192-197. doi: 10.1016/j.jad.2017.06.037. Epub 2017 Jun 19.
Gustavson KA, Alexopoulos GS, Niu GC, McCulloch C, Meade T, Arean PA. Problem-Solving Therapy Reduces Suicidal Ideation In Depressed Older Adults with Executive Dysfunction. Am J Geriatr Psychiatry. 2016 Jan;24(1):11-17. doi: 10.1016/j.jagp.2015.07.010. Epub 2015 Jul 30.
Alexopoulos GS, Raue PJ, Kiosses DN, Seirup JK, Banerjee S, Arean PA. Comparing engage with PST in late-life major depression: a preliminary report. Am J Geriatr Psychiatry. 2015 May;23(5):506-13. doi: 10.1016/j.jagp.2014.06.008. Epub 2014 Jun 26.
Other Identifiers
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DATR A4-GPS
Identifier Type: -
Identifier Source: secondary_id
H7472-19384-8
Identifier Type: -
Identifier Source: org_study_id
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