A Comparison of Cognitive and Dynamic Therapy for Depression in Community Settings

NCT ID: NCT01207271

Last Updated: 2017-05-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

237 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2014-12-09

Brief Summary

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The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic psychotherapy, with cognitive therapy for the treatment of depression in community mental health consumers.

Hypothesized mediators of treatment will also be examined.

Detailed Description

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The goal of this study is to conduct a randomized, comparative, non-inferiority clinical trial that tests the hypothesis that a widely used form of manualized dynamic psychotherapy (supportive-expressive psychodynamic therapy) is not inferior to cognitive therapy when implemented in community mental health settings for the treatment of major depressive disorder (MDD). The specific aims are (1) to conduct a randomized non-inferiority trial to compare supportive-expressive psychodynamic therapy and cognitive therapy for patients with MDD and (2) to assess the comparative effectiveness of supportive-expressive psychodynamic therapy and cognitive therapy on secondary measures of symptoms, patient functioning, and quality of life.

Patient mediators of outcome will also be examined through an additional grant awarded to Paul Crits-Christoph, Ph.D. This grant was funded by the National Institutes of Mental Health - RO1MH092363-01. This grant is entitled:"The mechanisms of cognitive and dynamic therapy in community settings."

Recruitment will occur solely through community mental health clinics in and around Philadelphia.

Conditions

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Major Depressive Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cognitive Therapy

Group Type EXPERIMENTAL

Cognitive Therapy

Intervention Type BEHAVIORAL

16 sessions of cognitive therapy administered weekly by a community mental health therapist

Dynamic Therapy

Group Type EXPERIMENTAL

Supportive-Expressive Psychodynamic Therapy

Intervention Type BEHAVIORAL

16 sessions of supportive-expressive psychodynamic therapy administered weekly by a community mental health therapist

Interventions

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Cognitive Therapy

16 sessions of cognitive therapy administered weekly by a community mental health therapist

Intervention Type BEHAVIORAL

Supportive-Expressive Psychodynamic Therapy

16 sessions of supportive-expressive psychodynamic therapy administered weekly by a community mental health therapist

Intervention Type BEHAVIORAL

Other Intervention Names

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Cognitive Behavioral Therapy CBT Psychodynamic Psychotherapy Short Term Dynamic Therapy

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of major depressive disorder
* Able to read at the 4th grade level or higher
* Willingness to be randomized and participate in research

Exclusion Criteria

* Current or past diagnosis of schizophrenia, seizure disorder, bipolar disorder, psychotic features, or clinically significant organic pathology
* Significant suicidal risk/ideation requiring immediate referral for more intensive treatment, or specific gesture in the last 6 months
* Current substance abuse or dependence requiring immediate referral to substance abuse program
* Acute medical problem requiring immediate inpatient treatment
* Need for referral to a partial hospitalization program
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Pennsylvania

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mary Beth Gibbons, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Paul Crits-Christoph, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Pennsylvania

Locations

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University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Countries

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United States

References

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Connolly Gibbons MB, Gallop R, Thompson D, Luther D, Crits-Christoph K, Jacobs J, Yin S, Crits-Christoph P. Comparative Effectiveness of Cognitive Therapy and Dynamic Psychotherapy for Major Depressive Disorder in a Community Mental Health Setting: A Randomized Clinical Noninferiority Trial. JAMA Psychiatry. 2016 Sep 1;73(9):904-11. doi: 10.1001/jamapsychiatry.2016.1720.

Reference Type DERIVED
PMID: 27487573 (View on PubMed)

Connolly Gibbons MB, Mack R, Lee J, Gallop R, Thompson D, Burock D, Crits-Christoph P. Comparative effectiveness of cognitive and dynamic therapies for major depressive disorder in a community mental health setting: study protocol for a randomized non-inferiority trial. BMC Psychol. 2014 Nov 11;2(1):47. doi: 10.1186/s40359-014-0047-y. eCollection 2014.

Reference Type DERIVED
PMID: 25566391 (View on PubMed)

Other Identifiers

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R01HS018440

Identifier Type: AHRQ

Identifier Source: org_study_id

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