Intensive Psychotherapy for Chronic Depression

NCT ID: NCT05221567

Last Updated: 2022-02-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 280 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2012-01-01
• Study Completion Date: 2017-12-31

Brief Summary

The study evaluates whether Intensive psychotherapy show superior effect on chronic depression over TAU

Detailed Description

Background: Accumulating evidence indicates that intensive psychotherapy (i.e., greater number of treatment sessions per time unit) improves outcomes for patients with mental health problems. However, few studies have investigated whether patients with chronic depression (CD) benefit from treatment with higher intensity. The main purpose of this study is to investigate if intensive psychotherapy could improve treatment for patients with chronic depression (CD). The primary research question is whether two intensive psychodynamic inpatient treatments, affect phobia therapy (APT) and VITA, are superior to low intensity treatment (TAU) at completion of treatment. To indicate if a potential difference between intensive treatment and TAU is due to the intensity of the therapy, the study contrasts two therapies with similar intensity, but different theoretical rationales. Methods: 280 patients with CD are included in a naturalistic study. Patients are assessed at four time points; assessment, start of therapy, end of therapy and 1-year follow-up. Three comparisons are performed with patients matched across groups; Intensive treatment (APT + VITA) vs TAU during treatment, APT vs VITA during treatment and APT vs VITA during follow-up. The outcome measure is the BDI-II.

Conditions

Chronic Depression; Persistent Depressive Disorder; Recurrent Major Depression

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

High intensity high dosage inpatient short-term psychodynamic psychotherapy (affect phobia therapy)

APT and VITA psychotherapy was carried out in accordance with treatment manuals. In addition to weekly individual sessions the inpatient program at both groups contained two 75 min group sessions each week. In addition, VITA had shorter group meetings each morning (15 minutes). Patients in both treatments participated in two physical exercise sessions per week, weekly psycho-educational lectures and art-therapy groups, and both groups finish each week with end of the week status groups. On average, patients in both treatments received seven sessions of therapeutic activity each week. All treatment components, with the exception of the physical exercises, adhered to the APT or VITA treatments, and thus the two intensive treatments were similar in dose but different in content. Medication was managed by psychiatrists, aiming to optimize the psychotropic medication regime, typically by reducing medication use.

Group Type: ACTIVE_COMPARATOR

Psychotherapy

Intervention Type: BEHAVIORAL

Intensive psychotherapy (i.e., greater number of treatment sessions per time unit)

Treatment-as-usual

TAU through public services locally, either outpatient treatment from a psychologist/psychiatrist and/or treatment/support from their local general practitioner.

Group Type: OTHER

Psychotherapy

Intervention Type: BEHAVIORAL

Intensive psychotherapy (i.e., greater number of treatment sessions per time unit)

High intensity high dosage inpatient short-term psychodynamic psychotherapy (VITA)

APT and VITA psychotherapy was carried out in accordance with treatment manuals. In addition to weekly individual sessions the inpatient program at both groups contained two 75 min group sessions each week. In addition, VITA had shorter group meetings each morning (15 minutes). Patients in both treatments participated in two physical exercise sessions per week, weekly psycho-educational lectures and art-therapy groups, and both groups finish each week with end of the week status groups. On average, patients in both treatments received seven sessions of therapeutic activity each week. All treatment components, with the exception of the physical exercises, adhered to the APT or VITA treatments, and thus the two intensive treatments were similar in dose but different in content. Medication was managed by psychiatrists, aiming to optimize the psychotropic medication regime, typically by reducing medication use.

Group Type: ACTIVE_COMPARATOR

Psychotherapy

Intervention Type: BEHAVIORAL

Intensive psychotherapy (i.e., greater number of treatment sessions per time unit)

Interventions

Psychotherapy

Intensive psychotherapy (i.e., greater number of treatment sessions per time unit)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Persistent depressive disorder as defined by the diagnostic and statistical manual of mental disorders (DSM5)
• Recurrent depressive disorder as defined by the International classification of diseases-10 (ICD-10)

Exclusion Criteria

• Not having utilized reasonably available treatment in proximity to their residence
• A psychotic disorder
• Cluster A or B personality disorder
• Bipolar disorder,
• Ongoing substance abuse,
• Physical brain disorder
• Not having access to TAU while on the 12 week wait-list period.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Modum Bad

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

KariAnne Vrabel, PhD

Role: STUDY_DIRECTOR

Leader Modum Bad Research Institute

References

Eielsen M, Ulvenes PG, Rossberg JI, Hostmaelingen A, Soma CS, Wampold BE. The Effectiveness of an Intensive Inpatient Psychotherapy Program for Chronic Depression: A naturalistic comparison with wait list. BMC Psychiatry. 2022 Nov 30;22(1):745. doi: 10.1186/s12888-022-04381-5.

Reference Type: DERIVED

PMID: 36451114 (View on PubMed)

Other Identifiers

ModumBad chronic depression

Identifier Type: -

Identifier Source: org_study_id