Clinical Trials
Showing trials with last updates posted in 2025.
1400
Participants
A Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care (SOC) Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-10-11
Completion:
2024-10-31
Conditions
Ovarian Neoplasms
Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma
Interventions
DRUG
380
Participants
Systemic Therapy With or Without Local Consolidative Therapy in Treating Patients With Oligometastatic Solid Tumor
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-07-31
Completion:
2029-12-31
Conditions
Oligometastatic Malignant Solid Neoplasm
Interventions
OTHER
PROCEDURE
No Results Yet
218
Participants
Efficacy and Safety of Plecanatide in Children 6 to <18 Years With Irritable Bowel Syndrome With Constipation (IBS-C)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-06-30
Completion:
2024-11-25
Conditions
Irritable Bowel Syndrome With Constipation
Interventions
DRUG
190
Participants
Long-term Safety and Efficacy Study of MT-8554 in Postmenopausal Women With Vasomotor Symptoms
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-04-18
Completion:
2019-11-15
Conditions
Vasomotor Symptoms (VMS)
Interventions
DRUG
30
Participants
Nutrition in Patient With Critical Limb Ischemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-10-02
Completion:
2026-06-30
Conditions
Critical Limb Ischemia
Malnutrition
Nutritional Supplements
Interventions
DRUG
No Results Yet
121
Participants
People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-10-19
Completion:
2032-12-31
Conditions
Diabetes Mellitus
Hepatitis C, Chronic
Cardiovascular Diseases
Interventions
DRUG
No Results Yet
102
Participants
Study to Evaluate Efficacy, Safety, and Tolerability of MT-7117 in Subjects With Erythropoietic Protoporphyria
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-07-05
Completion:
2019-09-28
Conditions
Erythropoietic Protoporphyria (EPP)
Interventions
DRUG
1500
Participants
Early Tracking of Childhood Health Determinants (ETCHED) Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2022-04-14
Completion:
2041-12-31
Conditions
Diabetes Mellitus
Obesity
Fatty Liver
No Results Yet
500
Participants
Pyruvate Kinase Deficiency Global Longitudinal Registry
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2018-04-23
Completion:
2027-05-31
Conditions
Pyruvate Kinase Deficiency
No Results Yet
152
Participants
Ophthalmological Abnormalities in Hereditary Ichthyosis (ICHTYO-KERATO)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2017-07-18
Completion:
2022-06-30
Conditions
Ichthyosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
170
Participants
Cortical Superficial Siderosis and Risk of Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy.
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-10-12
Completion:
2025-02-11
Conditions
Cerebral Amyloid Angiopathy
Interventions
OTHER
No Results Yet
750
Participants
Mechanisms of Familial Pulmonary Fibrosis
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2009-01-01
Completion:
2030-01-30
Conditions
Familial Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Familial Interstitial Pneumonia
No Results Yet
30
Participants
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-04-01
Completion:
2026-12-31
Conditions
Hepatic Encephalopathy
Interventions
DRUG
No Results Yet
26
Participants
Nivolumab in Treating Patients With Stage IIB-IIC Melanoma That Can Be Removed by Surgery
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-01-17
Completion:
2025-12-15
Conditions
Melanoma (Skin)
Interventions
BIOLOGICAL
No Results Yet
235
Participants
Venetoclax and Decitabine in Treating Participants With Relapsed/Refractory Acute Myeloid Leukemia or Relapsed High-Risk Myelodysplastic Syndrome
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-01-18
Completion:
2027-12-31
Conditions
Acute Myeloid Leukemia
Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome
Blastic Plasmacytoid Dendritic Cell Neoplasm
Chronic Myelomonocytic Leukemia
Mixed Phenotype Acute Leukemia
Myelodysplastic Syndrome
Recurrent Acute Biphenotypic Leukemia
Recurrent Acute Myeloid Leukemia
Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm
Recurrent Chronic Myelomonocytic Leukemia
Recurrent Mixed Phenotype Acute Leukemia
Refractory Acute Myeloid Leukemia
Refractory Blastic Plasmacytoid Dendritic Cell Neoplasm
Refractory Chronic Myelomonocytic Leukemia
Refractory Mixed Phenotype Acute Leukemia
Interventions
DRUG
OTHER
No Results Yet
236
Participants
The Aging Brain ANSWERS Program
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-08-01
Completion:
2023-05-31
Conditions
Traumatic Brain Injury
Alzheimer Disease
Veterans
Family Caregivers
Caregiver Burden
Quality of Life
Interventions
OTHER
No Results Yet
4100
Participants
Characterization and Treatment of Adolescent Depression
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2017-12-28
Completion:
2026-07-01
Conditions
Depression
Interventions
BEHAVIORAL
No Results Yet
1000
Participants
A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2017-11-16
Completion:
2026-07-05
Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG
No Results Yet
225
Participants
Chronic Venous Thrombosis: Relief With Adjunctive Catheter-Directed Therapy (The C-TRACT Trial)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-07-02
Completion:
2025-11-11
Conditions
Deep Vein Thrombosis
Venous Stasis
Venous Insufficiency
Venous Leg Ulcer
Venous Reflux
Post Thrombotic Syndrome
Interventions
DEVICE
No Results Yet
393
Participants
Sperm Selection by Microfluidic Separation Improves Embryo Quality
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2017-06-20
Completion:
2021-10-30
Conditions
Sperm DNA Fragmentation
Embryo Quality
Fertility Disorders
Infertility
Infertility, Male
Infertility Unexplained
Interventions
DEVICE
PROCEDURE
100
Participants
The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2017-03-13
Completion:
2026-09-30
Conditions
Polycystic Ovary Syndrome
Interventions
DRUG
OTHER
No Results Yet
29
Participants
Theophylline Treatment for Pseudohypoparathyroidism
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2018-09-01
Completion:
2026-12-01
Conditions
Pseudohypoparathyroidism
Albright Hereditary Osteodystrophy
Interventions
DRUG
No Results Yet
618
Participants
Study Evaluating the Efficacy, Safety, and Tolerability of Switching to Long-acting Cabotegravir Plus Long-acting Rilpivirine From Current Antiretroviral Regimen in Virologically Suppressed HIV-1-infected Adults
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-10-28
Completion:
2018-05-29
Conditions
Infection, Human Immunodeficiency Virus
HIV Infections
Interventions
DRUG
631
Participants
Study to Evaluate the Efficacy, Safety, and Tolerability of Long-acting Intramuscular Cabotegravir and Rilpivirine for Maintenance of Virologic Suppression Following Switch From an Integrase Inhibitor in HIV-1 Infected Therapy Naive Participants
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-10-27
Completion:
2018-08-30
Conditions
HIV Infections
Interventions
DRUG
1500
Participants
French Registry of Adult Patients With Immune Thrombocytopenia and Autoimmune Hemolytic Anemia
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2013-06-30
Completion:
2026-12-31
Conditions
Immune Thrombocytopenia
Autoimmune Hemolytic Anemia
Interventions
OTHER
No Results Yet
90
Participants
Stereotactic Radiotherapy for Oligo-Progressive Metastatic Cancer (The STOP Trial)
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-10-31
Completion:
2022-07-31
Conditions
Metastatic Cancer
Interventions
RADIATION
OTHER
No Results Yet
10
Participants
G-CSF in the Treatment of Toxic Epidermal Necrolysis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-07-31
Completion:
2023-03-07
Conditions
Stevens - Johnson Syndrome
Interventions
DRUG
No Results Yet
27
Participants
Glutaminergic Transmission in Autism : Molecular Imaging Exploration
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-04-30
Completion:
2018-11-15
Conditions
Autism
Fragile-X Syndrome (FXS)
Healthy Volunteers
Interventions
DRUG
OTHER
No Results Yet
17
Participants
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-06-15
Completion:
2022-12-16
Conditions
Astrocytoma, Grade IV
Giant Cell Glioblastoma
Glioblastoma Multiforme
Gliosarcoma
Interventions
RADIATION
No Results Yet
22
Participants
Brain Amyloid- Retention During Wakefulness and Following Emergence From Sleep in Healthy People
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2016-05-02
Completion:
2017-01-24
Conditions
Normal Physiology
Interventions
OTHER
No Results Yet
500
Participants
Rod and Cone Mediated Function in Retinal Disease
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2016-03-24
Completion:
2029-12-30
Conditions
Retinal Degeneration
Retinitis Pigmentosa
Stargardt's Disease
No Results Yet
148
Participants
High Image Matrix CT Reconstruction
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2015-11-09
Completion:
2020-03-27
Conditions
Healthy Subjects
Pulmonary-Related Conditions
Cardiac-Related Conditions
No Results Yet
40
Participants
Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2024-11-19
Completion:
2026-07-01
Conditions
Epilepsy
Interventions
DRUG
No Results Yet
877
Participants
An Extension Study of RPC1063 as Therapy for Moderate to Severe Ulcerative Colitis
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2015-12-02
Completion:
2024-12-19
Conditions
Ulcerative Colitis
Interventions
DRUG
10
Participants
Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2015-01-31
Completion:
2019-06-30
Conditions
Acute Pain
Chronic Pain
Hernia
Anesthesia, Intravenous
Anesthesia, Intratracheal
Interventions
DRUG
30
Participants
Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2025-12-19
Completion:
2026-12-01
Conditions
Intractable Pain
Palliative Care
Interventions
DRUG
No Results Yet
53
Participants
Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease
Study Type:
OBSERVATIONAL
Last Updated:
2025-12-31
Start Date:
2015-10-28
Completion:
2020-05-14
Conditions
Liver Disease
Fatty Liver
No Results Yet
54
Participants
Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2015-04-29
Completion:
2026-12-31
Conditions
Neurofibroma, Plexiform
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Promyelocytic, Acute
Sarcoma
Interventions
DRUG
No Results Yet
172
Participants
A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedreich's Ataxia
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2015-01-31
Completion:
2019-10-31
Conditions
Friedreich Ataxia
Interventions
DRUG
159
Participants
mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian
Study Type:
INTERVENTIONAL
Last Updated:
2025-12-31
Start Date:
2014-11-11
Completion:
2026-06-30
Conditions
BRCA1 Mutation Carrier
BRCA2 Mutation Carrier
Endometrial Adenocarcinoma
Estrogen Receptor Negative
HER2/Neu Negative
High Grade Ovarian Serous Adenocarcinoma
Progesterone Receptor Negative
Recurrent Breast Carcinoma
Recurrent Fallopian Tube Carcinoma
Recurrent Ovarian Carcinoma
Recurrent Primary Peritoneal Carcinoma
Recurrent Uterine Corpus Carcinoma
Stage III Uterine Corpus Cancer AJCC v7
Stage IV Breast Cancer AJCC v6 and v7
Stage IV Uterine Corpus Cancer AJCC v7
Triple-Negative Breast Carcinoma
Interventions
DRUG
OTHER
No Results Yet
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