Clinical Trials

NCT06694454 | NOT_YET_RECRUITING | PHASE1/PHASE2

60 Participants

Neoadjuvant Inhaled Azacytidine With Platinum-Based Chemotherapy and Durvalumab (MEDI4736) - a Combined Epigenetic-Immunotherapy (AZA-AEGEAN) Regimen for Operable Early-Stage Non-Small Cell Lung Cancer (NSCLC)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2031-12-31

Conditions

Non-small Cell Lung Cancer (NSCLC) Carcinoma, Non-Small Cell Lung Non-Small Cell Lung Carcinoma Non Small Cell Lung Cancer Non Small Cell Lung Carcinoma

Interventions

DRUG

No Results Yet

NCT06690294 | NOT_YET_RECRUITING

110 Participants

Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2026-01-30

Conditions

Healthy Volunteer Obestity

No Results Yet

NCT06680817 | RECRUITING

850 Participants

A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-02-05

Completion: 2027-06-30

Conditions

Neovascular Age-related Macular Degeneration Diabetic Macular Edema

Interventions

DRUG

No Results Yet

NCT06676059 | RECRUITING

10000 Participants

SMART-r: Substance Monitoring and Active Relapse Tracking Repository

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2044-12-31

Conditions

Alcoholism Substance-Related Disorders

No Results Yet

NCT06675032 | ACTIVE_NOT_RECRUITING | PHASE1

230 Participants

Phase I Clinical Trial of PCV24 in Children Aged 2 Months (Minimum 6 Weeks) to 17 Years

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-04-27

Completion: 2025-05-10

Conditions

Pneumococcal Infectious Disease

Interventions

BIOLOGICAL

No Results Yet

NCT06671392 | ACTIVE_NOT_RECRUITING | PHASE3

192 Participants

A Phase III Study to Efficacy and Safety of DWC202405/DWC202313 and DWC202314 in Patients With Hypertension

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-02-24

Completion: 2026-02-28

Conditions

Essential Hypertension

Interventions

DRUG

No Results Yet

NCT06665308 | COMPLETED

81 Participants

Cognitive Status, Fatigue and Inflammation in Patients With Immune Thrombocytopenia (ITP)

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-01-13

Completion: 2025-11-26

Conditions

Chronic Immune Thrombocytopenia Primary Immune Thrombocytopenia Adult Immune Thrombocytopenia

Interventions

OTHER

No Results Yet

NCT06664814 | RECRUITING | PHASE2

30 Participants

An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Primary Focal Segmental Glomerulosclerosis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2027-11-30

Conditions

Focal Segmental Glomerulosclerosis

Interventions

DRUG

No Results Yet

NCT06661915 | RECRUITING | PHASE2

62 Participants

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-08-14

Completion: 2027-12-31

Conditions

Accelerated Phase Myeloproliferative Neoplasm Blast Phase Myeloproliferative Neoplasm Essential Thrombocythemia Myelodysplastic/Myeloproliferative Neoplasm Myeloproliferative Neoplasm, Not Otherwise Specified Polycythemia Vera Primary Myelofibrosis Secondary Myelofibrosis

Interventions

PROCEDURE DRUG

No Results Yet

NCT06659666 | COMPLETED

100 Participants

The COPD Optimiser

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2024-10-09

Completion: 2025-01-20

Conditions

COPD

Interventions

DEVICE

No Results Yet

NCT06656819 | RECRUITING

50 Participants

The Modulatory Effect of Female Sex Hormones on Spinal Neuroplasticity

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2020-07-01

Completion: 2025-12-31

Conditions

Healthy

Interventions

DEVICE

No Results Yet

NCT06654778 | COMPLETED | NA

60 Participants

Ultrasound Evaluation of Preventive Measures for Postoperative Lung Atelectasis After Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-12-08

Completion: 2025-12-19

Conditions

Pulmonary Atelectasis, Postoperative

Interventions

OTHER

No Results Yet

NCT06654050 | NOT_YET_RECRUITING | PHASE2

15 Participants

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2027-12-01

Conditions

Mesothelioma Malignant Mesothelioma (MM) Early-stage Mesothelioma Subclinical Mesothelioma BRCA1-Associated Protein-1 (BAP1) Mutations Early-stage BAP1-associated Malignancies

Interventions

DRUG

No Results Yet

NCT06651281 | RECRUITING | PHASE3

1380 Participants

Extension Study of Long-term Safety and Efficacy of Tulisokibart in Participants With Crohn's Disease or Ulcerative Colitis (MK-7240-011)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-11-25

Completion: 2037-12-17

Conditions

Crohn Disease Colitis, Ulcerative

Interventions

DRUG

No Results Yet

NCT06650995 | RECRUITING | NA

40 Participants

AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2026-02-01

Completion: 2027-02-25

Conditions

HFpEF - Heart Failure With Preserved Ejection Fraction Atrial Fibrillation

Interventions

OTHER

No Results Yet

NCT06649812 | RECRUITING | PHASE2

120 Participants

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-10-07

Completion: 2027-09-01

Conditions

High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements Recurrent Diffuse Large B-Cell Lymphoma Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Interventions

PROCEDURE DRUG BIOLOGICAL

No Results Yet

NCT06646016 | WITHDRAWN | PHASE2

0 Participants

EPIC- Extracorporeal Photopheresis (ECP) for Immune-related Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-15

Completion: 2026-02-06

Conditions

Immune-related Colitis

Interventions

DRUG

No Results Yet

NCT06633250 | RECRUITING | NA

104 Participants

Effect of a Hydrolyzed Rice Protein-based Formula on Growth, Tolerance, and Health-related Quality of Life in Infants With Cow's Milk Protein Allergy.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-10-25

Completion: 2026-08-31

Conditions

Cow Milk Protein Allergy

Interventions

OTHER

No Results Yet

NCT06625177 | RECRUITING | PHASE1

36 Participants

A Trial to Test the Safety and Efficacy of TEV-53408 in Treating Vitiligo

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-11-11

Completion: 2026-05-09

Conditions

Vitiligo

Interventions

DRUG

No Results Yet

NCT06625112 | RECRUITING

120 Participants

A Multicentric European Study to Promote Clinical Trial Readiness for STXBP1-related Disorders

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-11-04

Completion: 2029-10-31

Conditions

STXBP1 Encephalopathy With Epilepsy

No Results Yet

NCT06615973 | RECRUITING

450 Participants

Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2026-02-01

Conditions

Brain Disease Vascular Diseases Cerebrovascular Disorder Stroke

No Results Yet

NCT06614725 | COMPLETED | PHASE3

751 Participants

A Study in India on the Immune Response and Safety of a Respiratory Syncytial Virus (RSV) Older Adults (OA) Vaccine When Given to Older Adults 60 Years of Age and Above and Adults 50-59 Years of Age at Increased Risk (AIR) of Respiratory Syncytial Virus Lower Respiratory Tract Disease (RSV-LRTD)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-10-01

Completion: 2025-06-03

Conditions

Respiratory Syncytial Virus Infections

Interventions

BIOLOGICAL COMBINATION_PRODUCT

No Results Yet

NCT06613724 | COMPLETED | NA

10 Participants

Magnetic Duodeno-Ileal Chile Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-10-14

Completion: 2025-02-27

Conditions

Obesity Type 2 Diabetes Mellitus (T2DM)

Interventions

DEVICE

No Results Yet

NCT06607003 | RECRUITING | PHASE1

200 Participants

Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-11-26

Completion: 2026-07-15

Conditions

Malaria

Interventions

BIOLOGICAL

No Results Yet

NCT06606990 | RECRUITING | PHASE1

40 Participants

Testing How the Body Responds to the Drug CX-5461 (Pidnarulex) in Patients With Metastatic Solid Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-07-01

Completion: 2026-12-31

Conditions

Metastatic Malignant Solid Neoplasm

Interventions

PROCEDURE BIOLOGICAL

No Results Yet

NCT06595940 | RECRUITING

400 Participants

Genetic Analysis of Uncommon Disease Presentations in Non-US Populations

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2034-08-21

Conditions

Undiagnosed Diseases Rare Diseases

No Results Yet

NCT06592378 | RECRUITING | NA

100 Participants

Opioid Management for Discharged Emergency Department Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-06-27

Completion: 2026-05-31

Conditions

Bone Fractures

Interventions

DEVICE

No Results Yet

NCT06589804 | RECRUITING | PHASE3

158 Participants

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-03-27

Completion: 2029-11-30

Conditions

Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Hypopharyngeal Squamous Cell Carcinoma Metastatic Laryngeal Squamous Cell Carcinoma Metastatic Oral Cavity Squamous Cell Carcinoma Metastatic Oropharyngeal Squamous Cell Carcinoma Recurrent Head and Neck Squamous Cell Carcinoma Recurrent Hypopharyngeal Squamous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Neck Squamous Cell Carcinoma of Unknown Primary Recurrent Oral Cavity Squamous Cell Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma Refractory Head and Neck Squamous Cell Carcinoma Refractory Hypopharyngeal Squamous Cell Carcinoma Refractory Laryngeal Squamous Cell Carcinoma Refractory Oral Cavity Squamous Cell Carcinoma Refractory Oropharyngeal Squamous Cell Carcinoma Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage IV Hypopharyngeal Carcinoma AJCC v8 Stage IV Laryngeal Cancer AJCC v8 Stage IV Lip and Oral Cavity Cancer AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8

Interventions

PROCEDURE BIOLOGICAL

No Results Yet

NCT06577454 | SUSPENDED | NA

60 Participants

Measuring the Effects of Neurostimulation on Risky and Ambiguous Decision-Making Capacity in People With and Without Substance Use Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2027-08-06

Conditions

Opioid Use Disorder Healthy Volunteers

Interventions

DEVICE

No Results Yet

NCT06577441 | RECRUITING | PHASE2

54 Participants

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-06-12

Completion: 2027-03-01

Conditions

Myelodysplastic Syndrome

Interventions

PROCEDURE DRUG

No Results Yet

NCT06575192 | RECRUITING | PHASE3

783 Participants

Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-11-05

Completion: 2029-12-31

Conditions

Breast Reconstruction

Interventions

DEVICE OTHER

No Results Yet

NCT06573294 | RECRUITING | PHASE1

45 Participants

Trial to Assess the Safety and Antitumor Activity of GEN1057 in Malignant Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-08-28

Completion: 2026-11-01

Conditions

Advanced Malignant Solid Tumors Metastatic Malignant Solid Tumors

Interventions

DRUG

No Results Yet

NCT06570811 | COMPLETED | PHASE2

40 Participants

Coenzyme Q10 and Chemotherapeutic Toxicity in Breast Cancer Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-08-01

Completion: 2025-03-10

Conditions

Breast Cancer Chemotherapeutic Toxicity

Interventions

DRUG

No Results Yet

NCT06570772 | TERMINATED | PHASE3

301 Participants

Study to Investigate Comparative Efficacy, Safety and Immunogenicity Between AVT16 and Entyvio

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-09-23

Completion: 2025-11-25

Conditions

Ulcerative Colitis

Interventions

BIOLOGICAL

No Results Yet

NCT06568172 | RECRUITING | PHASE3

420 Participants

Testing the Addition of an Immunotherapy Drug, Cemiplimab (REGN2810), Plus Surgery to the Usual Surgery Alone for Treating Advanced Skin Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-02-18

Completion: 2031-08-14

Conditions

Eyelid Squamous Cell Carcinoma Recurrent Eyelid Squamous Cell Carcinoma Recurrent Skin Acantholytic Squamous Cell Carcinoma Recurrent Skin Clear Cell Squamous Cell Carcinoma Recurrent Skin Lymphoepithelial Carcinoma Recurrent Skin Spindle Cell Squamous Cell Carcinoma Recurrent Skin Squamous Cell Carcinoma With Sarcomatoid Differentiation Resectable Eyelid Squamous Cell Carcinoma Resectable Skin Acantholytic Squamous Cell Carcinoma Resectable Skin Clear Cell Squamous Cell Carcinoma Resectable Skin Lymphoepithelial Carcinoma Resectable Skin Spindle Cell Squamous Cell Carcinoma Resectable Skin Squamous Cell Carcinoma With Sarcomatoid Differentiation Skin Acantholytic Squamous Cell Carcinoma Skin Clear Cell Squamous Cell Carcinoma Skin Lymphoepithelial Carcinoma Skin Spindle Cell Squamous Cell Carcinoma Skin Squamous Cell Carcinoma With Sarcomatoid Differentiation Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8

Interventions

PROCEDURE BIOLOGICAL RADIATION OTHER

No Results Yet

NCT06568055 | ACTIVE_NOT_RECRUITING

672 Participants

A Study of Cytomegalovirus (CMV) Infection After Kidney Transplant in Adults in the United Kingdom

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2024-09-30

Completion: 2025-10-31

Conditions

Cytomegalovirus (CMV)

Interventions

OTHER

No Results Yet

NCT06565442 | NOT_YET_RECRUITING

20 Participants

Feasibility of Using NeuraSignal Transcranial Doppler Robot

Study Type: OBSERVATIONAL

Last Updated: 2025-12-26

Start Date: 2026-02-15

Completion: 2026-12-14

Conditions

Cerebral Autoregulation

Interventions

DEVICE

No Results Yet

NCT06561828 | RECRUITING | EARLY_PHASE1

600 Participants

Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2025-12-30

Completion: 2044-11-01

Conditions

Normal Physiology

Interventions

DEVICE

No Results Yet

NCT06557733 | NOT_YET_RECRUITING | PHASE2

38 Participants

An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2026-06-07

Completion: 2026-12-17

Conditions

Familial Adenomatous Polyposis

Interventions

PROCEDURE DRUG OTHER

No Results Yet

NCT06555601 | TERMINATED | PHASE1

167 Participants

A First-in-human Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of UCB3101 in Healthy Participants

Study Type: INTERVENTIONAL

Last Updated: 2025-12-26

Start Date: 2024-07-31

Completion: 2025-11-24

Conditions

Healthy Participants

Interventions

DRUG

No Results Yet