Evaluation of the Safety and Effectiveness of ARTIA Reconstructive Tissue Matrix Breast Reconstruction (ADORA) in Adult Participants

NCT ID: NCT06575192

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

783 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-11-05

Study Completion Date

2029-12-31

Brief Summary

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The purpose of this study is to evaluate the safety and effectiveness of ARTIA in adult participants undergoing immediate, two-stage, implant-based breast reconstruction post-mastectomy.

Detailed Description

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Conditions

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Breast Reconstruction

Keywords

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Breast Reconstruction ADORA ARTIA

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Acellular Dermal Matrix

Breast reconstruction with ARTIA Tissue Matrix.

Group Type EXPERIMENTAL

ARTIA Reconstructive Tissue Matrix

Intervention Type DEVICE

Surgical Implant

Non-Acellular Dermal Matrix (ADM) Control Group

Breast reconstruction without ADM.

Group Type OTHER

No Intervention

Intervention Type OTHER

No ADM

Interventions

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ARTIA Reconstructive Tissue Matrix

Surgical Implant

Intervention Type DEVICE

No Intervention

No ADM

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Participants who will undergo unilateral or bilateral mastectomy upon enrollment.
* Participants who are willing and able to undergo immediate pre-pectoral two-stage breast reconstruction with ARTIA or without ADM.

Exclusion Criteria

* Has an existing carcinoma of the breast without planned mastectomy or residual gross local tumor of the breast after mastectomy.
* Has any disease which is clinically known to impact wound healing ability, such as uncontrolled diabetes or history of compromised wound healing.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Cedars-Sinai Medical Center /ID# 268326

Los Angeles, California, United States

Site Status RECRUITING

UC Irvine Medical Center /ID# 267428

Orange, California, United States

Site Status RECRUITING

Stanford University Medical Center CTRU - 800 Welch Road /ID# 264196

Palo Alto, California, United States

Site Status RECRUITING

South Bay Plastic Surgeons /ID# 264192

Torrance, California, United States

Site Status RECRUITING

University of Florida College of Medicine /ID# 267485

Gainesville, Florida, United States

Site Status RECRUITING

Endeavor Health /ID# 266302

Northbrook, Illinois, United States

Site Status RECRUITING

Johns Hopkins Hospital /ID# 265917

Baltimore, Maryland, United States

Site Status RECRUITING

Washington University School of Medicine - St. Louis /ID# 264029

St Louis, Missouri, United States

Site Status RECRUITING

University of Nevada - Main Campus /ID# 264017

Las Vegas, Nevada, United States

Site Status RECRUITING

Rutgers New Jersey Medical School - Newark /ID# 264187

Newark, New Jersey, United States

Site Status RECRUITING

Northwell Health Clinical Trials Office /ID# 268076

Lake Success, New York, United States

Site Status RECRUITING

NYU Langone Medical Center /ID# 265621

New York, New York, United States

Site Status COMPLETED

Atrium Health Wake Forest Baptist Medical Center /ID# 264382

Winston-Salem, North Carolina, United States

Site Status RECRUITING

Ohio State University Comprehensive Cancer Center /ID# 266253

Columbus, Ohio, United States

Site Status RECRUITING

Erlanger Health System /ID# 266608

Chattanooga, Tennessee, United States

Site Status RECRUITING

The University of Texas MD Anderson Cancer Center /ID# 264020

Houston, Texas, United States

Site Status RECRUITING

University of Virginia /ID# 265098

Charlottesville, Virginia, United States

Site Status RECRUITING

AG Aesthetic Center /ID# 264233

Vancouver, Washington, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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ABBVIE CALL CENTER

Role: CONTACT

Phone: 844-663-3742

Email: [email protected]

Related Links

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Other Identifiers

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M24-708

Identifier Type: -

Identifier Source: org_study_id