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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05991622 | ACTIVE_NOT_RECRUITING | PHASE2
40 Participants

Combined Injectable Treatment for HIV and OUD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-04-01
Completion: 2025-08-27
Conditions
Human Immunodeficiency Virus Opioid Use Disorder
Interventions
DRUG
No Results Yet
NCT05989711 | COMPLETED | PHASE2
212 Participants

IMPACT TRIAL: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-27
Completion: 2025-04-29
Conditions
Non-Alcoholic Steatohepatitis (NASH)
Interventions
DRUG
No Results Yet
NCT05987241 | RECRUITING | PHASE2/PHASE3
992 Participants

Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-02
Completion: 2030-09-02
Conditions
Muscle Invasive Bladder Urothelial Carcinoma Muscle Invasive Renal Pelvis Urothelial Carcinoma Muscle Invasive Ureter Urothelial Carcinoma Muscle Invasive Urethral Urothelial Carcinoma Stage II Bladder Urothelial Carcinoma AJCC v6 and v7 Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 Stage IV Bladder Urothelial Carcinoma AJCC v7
Interventions
PROCEDURE OTHER BIOLOGICAL
No Results Yet
NCT05983991 | RECRUITING | NA
150 Participants

Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-07
Completion: 2033-12-31
Conditions
GATA2 Gene Mutation
Interventions
OTHER
No Results Yet
NCT05973383 | NOT_YET_RECRUITING
1500 Participants

Evaluation of a Personalised Digital Intervention (EviBody) for Healthy and Sustained Lifestyle Behaviors and Well-being Among Adults: a Real-world Quasi-experimental Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2026-01-01
Completion: 2026-12-31
Conditions
Well-being
Interventions
BEHAVIORAL
No Results Yet
NCT05969002 | RECRUITING
36 Participants

Pilot Prospective Study for PET-CT Imaging in Participants With Relapsed/Refractory Acute Leukemias

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-08-25
Completion: 2025-12-31
Conditions
B Cell Acute Lymphoblastic Leukemia Relapsed/Refractory
No Results Yet
NCT05963984 | COMPLETED | PHASE2
60 Participants

A Study of Samuraciclib in Combination With Fulvestrant in Metastatic or Locally Advanced Breast Cancer in Adult Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-16
Completion: 2025-03-20
Conditions
Metastatic Breast Cancer Locally Advanced Breast Cancer Breast Cancer
Interventions
DRUG
No Results Yet
NCT05958043 | COMPLETED | NA
20 Participants

Performance of CAD/CAM Milled and 3D-printed Full-arch Implant-supported Provisionals Restorations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-03-01
Completion: 2025-05-01
Conditions
Edentulous Jaw Dental Prosthesis Complication Dental Prosthesis Failure
Interventions
DEVICE
No Results Yet
NCT05954312 | RECRUITING | PHASE1
290 Participants

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130037 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-28
Completion: 2030-08-31
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT05952752 | COMPLETED | NA
382 Participants

Dexemedetomidine on Shivering Cesarean Section Under Spinal Anesthesia A Randomized Clinical Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-20
Completion: 2023-09-25
Conditions
Postoperative Shivering
Interventions
OTHER
No Results Yet
NCT05947539 | ENROLLING_BY_INVITATION | NA
80 Participants

Improving HIV Care Engagement Among Ugandan Adolescent Girls and Young Women: The Kisoboka Mukwano Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-01
Completion: 2026-10-30
Conditions
HIV-infection/Aids Intimate Partner Violence Domestic Violence Alcohol Use Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT05932745 | RECRUITING | NA
66 Participants

Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2025-06-20
Completion: 2026-05-31
Conditions
Nicotine Use Disorder
Interventions
OTHER
No Results Yet
NCT05923983 | COMPLETED | NA
783 Participants

DETECT-IP: a Clinical Decision Support System and Intelligent Procedures to Counter Some Adverse Drug Events in Older Hospital Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-10-02
Completion: 2024-10-03
Conditions
Patient Acceptance of Health Care Acute Renal Failure
Interventions
OTHER
No Results Yet
NCT05919979 | COMPLETED | NA
25 Participants

Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-05-29
Completion: 2025-06-11
Conditions
Energy Metabolism
Interventions
BEHAVIORAL
No Results Yet
NCT05919472 | COMPLETED | NA
180 Participants

Effects of Oral Iron Supplementation on Vaccine Response in Iron Deficient Kenyan Women

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-01
Completion: 2024-07-16
Conditions
Iron Deficiency Anemia
Interventions
DIETARY_SUPPLEMENT BIOLOGICAL
No Results Yet
NCT05912582 | NOT_YET_RECRUITING
60 Participants

Prospective Study for Molecular Biomarkers and Spatial Transcriptomics of Nasopharyngeal Carcinoma

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2025-12-25
Completion: 2027-06-25
Conditions
Nasopharyngeal Carcinoma
Interventions
RADIATION
No Results Yet
NCT05909202 | RECRUITING | NA
218 Participants

A Nature-Based Virtual Reality (VR) Intervention in Family Caregivers of Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Recipients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-06-05
Completion: 2027-09-01
Conditions
Neoplasm Caregivers
Interventions
DEVICE
No Results Yet
NCT05904080 | RECRUITING | PHASE2
50 Participants

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-02-19
Completion: 2028-06-16
Conditions
Metastatic Nasopharyngeal Carcinoma Recurrent Nasopharyngeal Carcinoma Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT05899998 | ACTIVE_NOT_RECRUITING | NA
40 Participants

Bright IDEAS for Pediatric Palliative Care: A Problem-Solving Skills Intervention to Empower Parent Resilience

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-08-08
Completion: 2026-05-31
Conditions
Psychological Distress Quality of Life
Interventions
BEHAVIORAL
No Results Yet
NCT05898646 | RECRUITING | PHASE2
96 Participants

Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-17
Completion: 2026-12-31
Conditions
AL Amyloidosis
Interventions
PROCEDURE BIOLOGICAL OTHER
No Results Yet
NCT05896839 | RECRUITING | PHASE1/PHASE2
16 Participants

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-07-24
Completion: 2027-01-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 Metastatic Basal Cell Carcinoma Metastatic Carcinoma in the Skin Metastatic Melanoma Metastatic Merkel Cell Carcinoma Metastatic Skin Squamous Cell Carcinoma Unresectable Basal Cell Carcinoma Unresectable Melanoma Unresectable Merkel Cell Carcinoma Unresectable Skin Squamous Cell Carcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05892432 | COMPLETED | PHASE2
50 Participants

Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-01-11
Completion: 2025-11-04
Conditions
Alcohol Use Disorder
Interventions
DRUG
No Results Yet
NCT05866419 | RECRUITING | NA
90 Participants

Study of an Intrathecal Port and Catheter System for Subjects With Spinal Muscular Atrophy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-27
Completion: 2026-05-31
Conditions
Spinal Muscular Atrophy Spine Deformity Scoliosis
Interventions
DEVICE
No Results Yet
NCT05859334 | RECRUITING | PHASE2
35 Participants

Testing the Anti-cancer Drug Erdafitinib for Brain Cancers That Have Returned or Progressed Following Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-01-04
Completion: 2026-10-23
Conditions
Recurrent Glioma Recurrent WHO Grade 2 Glioma Recurrent WHO Grade 3 Glioma Recurrent WHO Grade 4 Glioma
Interventions
PROCEDURE DRUG
No Results Yet
NCT05856838 | RECRUITING | NA
30 Participants

NovaSure Study: Endometrial Ablation in Women With Heavy Menstrual Bleeding

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-24
Completion: 2026-01-01
Conditions
Menstrual Bleeding, Heavy
Interventions
DEVICE
No Results Yet
NCT05836025 | ACTIVE_NOT_RECRUITING | PHASE2
50 Participants

Effect of Rapamycin in Ovarian Aging

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-01
Completion: 2025-10-21
Conditions
Perimenopausal
Interventions
DRUG OTHER
No Results Yet
NCT05827887 | RECRUITING
200 Participants

An Observational Study to Assess Ubrogepant Tablets and Atogepant Tablets to Treat Migraine in Adult Participants

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-25
Completion: 2026-02-28
Conditions
Migraine
No Results Yet
NCT05818709 | COMPLETED | PHASE3
61 Participants

A Study to Assess Adverse Events and Effectiveness of HAC 22L Injection for Mid-Face Volume in Adult Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-14
Completion: 2025-12-05
Conditions
Facial Volume Deficit
Interventions
DEVICE
No Results Yet
NCT05816187 | COMPLETED | NA
78 Participants

Efficacy and Safety of Supervised Therapeutic Exercise in Cancer Patients With and Without Concurrent Treatment.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-03-15
Completion: 2025-09-01
Conditions
Breast Cancer Colon Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT05814627 | ACTIVE_NOT_RECRUITING | PHASE3
487 Participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-15
Completion: 2026-07-31
Conditions
Rheumatoid Arthritis
Interventions
DRUG
No Results Yet
NCT05812053 | RECRUITING | NA
30 Participants

Comparative Evaluation of Eggshell Powder in Primary Teeth Pulpotomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-04-01
Completion: 2026-01-31
Conditions
Pulpitis Reversible Pulp Exposure, Dental
Interventions
PROCEDURE RADIATION
No Results Yet
NCT05804227 | RECRUITING | EARLY_PHASE1
20 Participants

Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-04-20
Completion: 2027-09-22
Conditions
Gliomas
Interventions
DRUG
No Results Yet
NCT05798676 | RECRUITING
130 Participants

Maternal Characteristics Associated With Child Growth and Adiposity

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2019-05-02
Completion: 2028-03-31
Conditions
Obesity Obesity, Infant
Interventions
OTHER
No Results Yet
NCT05782907 | ACTIVE_NOT_RECRUITING | PHASE3
122 Participants

Study to Assess Adverse Events, Change in Disease Activity, and How Oral Upadacitinib Moves Through the Body of Pediatric Participants With Moderately to Severely Active Ulcerative Colitis.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-11-06
Completion: 2028-08-31
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT05779462 | RECRUITING
52 Participants

ENDOMETRIOSIS - MRI

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-05-23
Completion: 2026-07-31
Conditions
Endometriosis Mobility Limitation Magnetic Resonance Imaging Diagnosis Pelvis Comparative Study
Interventions
OTHER
No Results Yet
NCT05777993 | ENROLLING_BY_INVITATION | PHASE4
6 Participants

A Study to Provide Continued Access to Mitapivat for Participants Who Previously Completed an Agios-Sponsored Mitapivat Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-07-06
Completion: 2029-08-31
Conditions
Pyruvate Kinase Deficiency Anemia, Hemolytic
Interventions
DRUG
No Results Yet
NCT05774678 | RECRUITING | PHASE3
126 Participants

Trial Of PreoperAtive Radiation (TOPAz): A Randomized Trial Comparing Hypofractionated Versus Conventionally Fractionated Preoperative Radiation Followed by Mastectomy With Immediate Autologous Breast Reconstruction With Integrated Nanomechanical Biomarker Evaluation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-04-05
Completion: 2026-11-01
Conditions
Breast Cancer
Interventions
RADIATION OTHER
No Results Yet
NCT05774600 | COMPLETED | NA
641 Participants

Virtual Sun Safe Workplaces Ph II (SSW Works)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-06-01
Completion: 2025-02-25
Conditions
Skin Cancer Occupational Exposure
Interventions
BEHAVIORAL
No Results Yet
NCT05773274 | RECRUITING | PHASE2
100 Participants

Comparing Retreatment of 177Lu-DOTATATE PRRT Versus the Usual Treatment in Patients With Metastatic Unresectable Gastroenteropancreatic Neuroendocrine Tumors, NET RETREAT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-01-12
Completion: 2026-04-30
Conditions
Metastatic Digestive System Neuroendocrine Tumor G1 Metastatic Digestive System Neuroendocrine Tumor G2 Unresectable Digestive System Neuroendocrine Tumor G1 Unresectable Digestive System Neuroendocrine Tumor G2
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT05765812 | RECRUITING | PHASE1/PHASE2
116 Participants

A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-05-15
Completion: 2028-09-30
Conditions
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype Astrocytoma, Grade III
Interventions
DRUG RADIATION
No Results Yet
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