Prospective Study for Molecular Biomarkers and Spatial Transcriptomics of Nasopharyngeal Carcinoma
NCT ID: NCT05912582
Last Updated: 2025-12-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
60 participants
OBSERVATIONAL
2025-12-25
2028-12-25
Brief Summary
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Detailed Description
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Secondary endpoint: Evaluation of failure-free survival and overall survival of nasopharyngeal carcinoma patients.
Outline: This is a prospective observational study. Patients of nasopharyngeal carcinoma undergo inductive chemotherapy and concurrent chemoradiotherapy. Whole blood is obtained from patients when recruited, completing 10, 20, 32 fractions of radiation therapy, 3 months after radiation therapy and disease progression. Tumor tissue specimens are obtained from patients when recruited and disease progression. The samples are analyzed for biomarkers and spatial transcriptomics. The biomarkers and spatial transcriptomics are correlated with clinical outcomes (major pathological response, progression-free survival, overall survival, tumor response to treatment, distant metastasis, recurrence and death).
The analysis aims to explore potential biomarkers and validate molecular signatures' predictive and prognostic value in nasopharyngeal carcinoma. This will lead to the definition of risk groups and stratification of patients and will help in precision medicine of nasopharyngeal carcinoma.
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Observation Group
Intensity modulated radiation therapy (IMRT) combined with chemotherapy
Intensity modulated radiation therapy (IMRT) combined with chemotherapy
Interventions
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Intensity modulated radiation therapy (IMRT) combined with chemotherapy
Intensity modulated radiation therapy (IMRT) combined with chemotherapy
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. No evidence of distant metastasis (M0)
3. Written informed consent
Exclusion Criteria
18 Years
80 Years
ALL
No
Sponsors
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Jiangsu Cancer Institute & Hospital
OTHER
Responsible Party
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Lirong Wu
Associate Professor
Locations
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Jiangsu Cancer Hospital
Nanjing, , China
Countries
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Central Contacts
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Facility Contacts
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Lirong Wu
Role: primary
Other Identifiers
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Biomarkers- NPC
Identifier Type: -
Identifier Source: org_study_id