Effect of a Physical Exercise Session Performed During a 24-34 Hour Fasting Period on Energy Metabolism and Cognitive Function in Healthy Adults

NCT ID: NCT05919979

Last Updated: 2025-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-29

Study Completion Date

2025-06-18

Brief Summary

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This study explores the impact of high-intensity exercise during fasting on energy metabolism and cognitive function in healthy adults. Changes in respiratory exchange ratio, blood substances, and cognitive performance will be measured after 24 and 34 hours of fasting with and without exercise in a randomized crossover design.

Detailed Description

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Conditions

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Energy Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Fasting, then fasting+exercise

Group Type EXPERIMENTAL

34-hour fasting in sedentary conditions

Intervention Type BEHAVIORAL

Participants will fast for 34h after a standardized breakfast, refraining from physical activity.

34-hour fasting with high-intensity exercise

Intervention Type BEHAVIORAL

Participants will fast for 34h after a standardized breakfast, performing a high-intensity exercise session 6-10 hours aprox. after starting the fasting period.

Fasting + Exercise, then fasting

Group Type EXPERIMENTAL

34-hour fasting in sedentary conditions

Intervention Type BEHAVIORAL

Participants will fast for 34h after a standardized breakfast, refraining from physical activity.

34-hour fasting with high-intensity exercise

Intervention Type BEHAVIORAL

Participants will fast for 34h after a standardized breakfast, performing a high-intensity exercise session 6-10 hours aprox. after starting the fasting period.

Interventions

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34-hour fasting in sedentary conditions

Participants will fast for 34h after a standardized breakfast, refraining from physical activity.

Intervention Type BEHAVIORAL

34-hour fasting with high-intensity exercise

Participants will fast for 34h after a standardized breakfast, performing a high-intensity exercise session 6-10 hours aprox. after starting the fasting period.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18-40 years old.
* Body mass index: 18.5-30.0 Kg/m2.
* Stable body weight (5kg range within the last 3 months)
* Being able to consume all the food items provided as part of the study.
* Not having change the time zone or have shifted sleeping hours equivalent to more than 3 hours on the previous 2 weeks.

Exclusion Criteria

* Diagnosed with any chronic condition that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
* Diagnosed with a chronic endocrine, digestive, rheumatic, neurological, cardiac, pulmonary, autoimmune, or infectious condition that affects energy metabolism.
* Presenting any signs or symptoms of illness that, in the research team's opinion or based on the American College of Sports Medicine guidelines, could contraindicate the implementation of 34-hour fasting periods and/or high-intensity exercise.
* Pregnant or breastfeeding.
* Using medications or supplements that may alter energy metabolism.
* Currently undergoing or having undergone any type of nutritional intervention or treatment in the past 3 months.
* Engaging in more than 5 hours per week of habitual moderate-to-vigorous cycling.
* Any other condition that, in the research team's opinion, discourages participation in the study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital Virgen de las Nieves

OTHER

Sponsor Role collaborator

Universidad de Granada

OTHER

Sponsor Role lead

Responsible Party

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Guillermo Sanchez Delgado

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Instiuto Mixto Universitario Deporte y Salud

Granada, Granada, Spain

Site Status

Countries

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Spain

Other Identifiers

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GSD-2023-002

Identifier Type: -

Identifier Source: org_study_id