Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

NCT ID: NCT05814627

Last Updated: 2025-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

487 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-06-15

Study Completion Date

2026-07-31

Brief Summary

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Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will assess how safe and effective upadacitinib is in treating RA when compared to adalimumab in adult participants with inadequate response or intolerance to one TNF-inhibitor who are on a stable dose of methotrexate (MTX). Adverse events and change in disease activity will be assessed.

Upadacitinib is an approved drug for the treatment of RA. This study is double-blinded means that neither the participants nor the study doctors will know who will be given upadacitinib and who will be given adalimumab. Study doctors put the participants in 1 of the 2 groups, called treatment arms randomly, to receive either upadacitinib or adalimumab. There is 1 in 2 chance that participants will receive adalimumab. Each group consists of 2 periods. Approximately 480 participants diagnosed with RA will be enrolled in approximately 250 sites across the world.

Participants will receive the oral upadacitinib once daily and matching adalimumab placebo every other week, or the subcutaneous adalimumab every other week and matching upadacitinib placebo once daily during Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1 and will be followed for 30 days and 70 days.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, checking for side effects and completing questionnaires.

Detailed Description

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Conditions

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Rheumatoid Arthritis

Keywords

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Rheumatoid Arthritis RA Upadacitinib Adalimumab Methotrexate MTX TNF Inhibitor

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Upadacitinib+ Adalimumab matching Placebo

Participants will receive upadacitinib once a day along with matching placebo for adalimumab at eow (every other week) in Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1.

Group Type EXPERIMENTAL

Upadacitinib

Intervention Type DRUG

Oral Tablets

Adalimumab Matching Placebo

Intervention Type DRUG

Subcutaneous Injection

Adalimumab + Upadacitinib matching Placebo

Participants will receive adalimumab at eow (every other week) along with matching placebo for upadacitinib once a day in Period 1. Eligible participants will continue to receive same study treatment in Period 2 as assigned in Period 1.

Group Type EXPERIMENTAL

Adalimumab

Intervention Type DRUG

Subcutaneous Injection

Upadacitinib Matching Placebo

Intervention Type DRUG

Oral Tablets

Interventions

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Upadacitinib

Oral Tablets

Intervention Type DRUG

Adalimumab

Subcutaneous Injection

Intervention Type DRUG

Upadacitinib Matching Placebo

Oral Tablets

Intervention Type DRUG

Adalimumab Matching Placebo

Subcutaneous Injection

Intervention Type DRUG

Other Intervention Names

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RINVOQ Humira

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Rheumatoid Arthritis (RA) for \>= 3 months based on the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) classification criteria for RA.
* Treated for \>= 3 consecutive months prior to screening with 1 tumor necrosis factor inhibitor (TNFi) (only 1 of originator or biosimilar certolizumab pegol, etanercept, golimumab or infliximab) for RA, but continue to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. Up to 15% of participants who were intolerant to 1 TNFi will be allowed to enroll. Prior administration of different biosimilar versions for the same originator TNFi or switching between originator and biosimilar version of the same originator TNFi are acceptable. Cycling between biosimilars of different originator TNF inhibitors is not acceptable.
* On oral or parenteral methotrexate (MTX) therapy \>= 3 consecutive months and on a stable prescription of 15 to 25 mg/week (or \>= 10 mg/week in participants intolerant of MTX at doses \>= 15 mg/week) for \>= 4 weeks prior to the first dose of study drug. In addition, all participants should take a dietary supplement of folic acid or folinic acid throughout the study participation.

* For a Chinese, Japanese, Korean, or Taiwanese participant, a stable dose of MTX \>= 7.5 mg/week is acceptable.
* Additional local requirements for MTX may apply.
* Meets both of the following disease activity criteria:

* \>= 6 swollen joint (based on 66 joint counts) and \>= 6 tender joints (based on 68 joint counts) at screening and baseline;
* High-sensitivity C-reactive protein (hsCRP) \>= 3 mg/L (central lab, upper limit of normal \[ULN\] 2.87 mg/L) at screening.

Exclusion Criteria

* History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than Rheumatoid Arthritis (RA).
* Prior exposure to any janus kinase (JAK) inhibitor.
* Prior exposure to adalimumab (original or biosimilar) or to any approved or investigational TNF inhibitor other than infliximab, etanercept, certolizumab pegol and golimumab.
* Prior exposure to an approved or investigational non-TNFi biologic disease modifying anti-rheumatic drug (bDMARD) or targeted synthetic disease modifying antirheumatic drug (tsDMARD).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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AZ Arthritis and Rheumotology Research, PLLC - Flagstaff /ID# 253431

Flagstaff, Arizona, United States

Site Status

Arizona Arthritis and Rheumatology Research - Glendale Office /ID# 255018

Glendale, Arizona, United States

Site Status

Sun Valley Arthritis Center Ltd. /ID# 254654

Peoria, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 253432

Phoenix, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Associates - East Bell Road /ID# 255021

Phoenix, Arizona, United States

Site Status

Arizona Arthritis & Rheumatology Associates - Tucson /ID# 255017

Tucson, Arizona, United States

Site Status

Arthritis and Rheumatism Associates /ID# 254013

Jonesboro, Arkansas, United States

Site Status

Providence - St. Jude Medical Center /ID# 252690

Fullerton, California, United States

Site Status

Newport Huntington Medical Group /ID# 252687

Huntington Beach, California, United States

Site Status

Purushotham & Akther Kotha MD, Inc /ID# 252704

La Mesa, California, United States

Site Status

Valerius Medical Group & Research Center of Greater Long Beach, Inc /ID# 252692

Los Alamitos, California, United States

Site Status

Rheumatology Center of San Diego /ID# 255038

San Diego, California, United States

Site Status

Millennium Clinical Trials /ID# 252689

Thousand Oaks, California, United States

Site Status

The Lundquist Institute at Harbor-UCLA Medical Center /ID# 252691

Torrance, California, United States

Site Status

Comprehensive Rheumatology Center /ID# 252688

Woodland Hills, California, United States

Site Status

University of Colorado Hospital /ID# 254617

Aurora, Colorado, United States

Site Status

Denver Arthritis Clinic /ID# 254058

Denver, Colorado, United States

Site Status

Tekton Research - Fort Collins - East Harmony Road /ID# 255036

Fort Collins, Colorado, United States

Site Status

Arthritis and Rheumatic Disease Specialties /ID# 260583

Aventura, Florida, United States

Site Status

Rheumatology Associates of South Florida (RASF) - Clinical Research /ID# 253733

Boca Raton, Florida, United States

Site Status

Bay Area Arthritis and Osteo /ID# 254046

Brandon, Florida, United States

Site Status

Believe Clinical Trial /ID# 262355

Coral Springs, Florida, United States

Site Status

International Medical Research /ID# 254651

Daytona Beach, Florida, United States

Site Status

Omega Research Debary, LLC /ID# 253735

DeBary, Florida, United States

Site Status

Neoclinical Research /ID# 254622

Hialeah, Florida, United States

Site Status

Gnp Research - Hollywood /ID# 273563

Hollywood, Florida, United States

Site Status

Life Clinical Trials /ID# 256061

Margate, Florida, United States

Site Status

Lakes Research, LLC /ID# 255023

Miami, Florida, United States

Site Status

HMD Research LLC /ID# 253732

Orlando, Florida, United States

Site Status

Millennium Research /ID# 253744

Ormond Beach, Florida, United States

Site Status

Vitalia Research /ID# 274213

Palm Beach Gardens, Florida, United States

Site Status

BayCare Medical Group /ID# 253799

St. Petersburg, Florida, United States

Site Status

Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 254649

Tampa, Florida, United States

Site Status

Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 255264

Tampa, Florida, United States

Site Status

University of South Florida- Neuroscience Institute /ID# 253745

Tampa, Florida, United States

Site Status

Baycare Medical Group - Tampa /ID# 255268

Tampa, Florida, United States

Site Status

Atlanta Research Center For Rheumatology - Marietta /ID# 254623

Marietta, Georgia, United States

Site Status

Next Innovative Clinical Research - Chicago /ID# 273453

Chicago, Illinois, United States

Site Status

Deerbrook Medical Associates /ID# 254008

Libertyville, Illinois, United States

Site Status

OrthoIllinois /ID# 254057

Rockford, Illinois, United States

Site Status

Greater Chicago Specialty Physicians /ID# 254000

Schaumburg, Illinois, United States

Site Status

Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 253999

Skokie, Illinois, United States

Site Status

Willow Rheumatology and Wellness, PLLC /ID# 254712

Willowbrook, Illinois, United States

Site Status

Qualmedica Research - Evansville /ID# 254005

Evansville, Indiana, United States

Site Status

Western KY Rheumatology /ID# 255026

Hopkinsville, Kentucky, United States

Site Status

Bluegrass Community Research /ID# 254653

Lexington, Kentucky, United States

Site Status

Ochsner Health Center - The Grove /ID# 254059

Baton Rouge, Louisiana, United States

Site Status

The Arthritis & Diabetes Clinic, Inc. /ID# 254014

Monroe, Louisiana, United States

Site Status

Rheumatology Associates PA - Portland /ID# 255014

Portland, Maine, United States

Site Status

Beth Israel Deaconess Medical Center - Rheumatology /ID# 255029

Boston, Massachusetts, United States

Site Status

AA Medical Research Center - Grand Blanc /ID# 254007

Grand Blanc, Michigan, United States

Site Status

Advanced Rheumatology, PC /ID# 256059

Okemos, Michigan, United States

Site Status

St. Paul Rheumatology, PA /ID# 255037

Eagan, Minnesota, United States

Site Status

Arthritis Associates /ID# 253992

Hattiesburg, Mississippi, United States

Site Status

Kansas City Physician Partners /ID# 255035

Kansas City, Missouri, United States

Site Status

Clinvest Research LLC /ID# 254054

Springfield, Missouri, United States

Site Status

Logan Health Research - Glacier View Research Institute - Rheumatology /ID# 253738

Kalispell, Montana, United States

Site Status

Physician Research Collaboration, LLC /ID# 254012

Lincoln, Nebraska, United States

Site Status

Dartmouth-Hitchcock Medical Center /ID# 253798

Lebanon, New Hampshire, United States

Site Status

Arthritis Rheumatic and Back Disease Associates. P.A. /ID# 255266

Voorhees Township, New Jersey, United States

Site Status

Arthritis and Osteoporosis Associates of New Mexico /ID# 252684

Las Cruces, New Mexico, United States

Site Status

NYU Langone Ambulatory Care Brooklyn Heights /ID# 254621

Brooklyn, New York, United States

Site Status

Joint And Muscle Research Institute /ID# 275128

Charlotte, North Carolina, United States

Site Status

Trinity Health Med Arts Clinic /ID# 254010

Minot, North Dakota, United States

Site Status

Paramount Medical Research and Consulting /ID# 254048

Middleburg Heights, Ohio, United States

Site Status

Rheumatology Associates of Oklahoma /ID# 253994

Oklahoma City, Oklahoma, United States

Site Status

Clinical Research of Philadelphia, LLC /ID# 255025

Philadelphia, Pennsylvania, United States

Site Status

West Tennessee Research Institute /ID# 254620

Jackson, Tennessee, United States

Site Status

Arthritis and Rheumatology Research Institute, PLLC /ID# 254045

Allen, Texas, United States

Site Status

Tekton Research, L.L.C /ID# 254004

Austin, Texas, United States

Site Status

Trinity Universal Research Associates - Carrollton /ID# 254648

Carrollton, Texas, United States

Site Status

Adriana Pop-Moody MD Clinic PA /ID# 255030

Corpus Christi, Texas, United States

Site Status

JPS Rheumatology Clinic /ID# 254050

Fort Worth, Texas, United States

Site Status

Biopharma Informatic - Houston - Business Center Drive /ID# 254051

Houston, Texas, United States

Site Status

Biopharma Informatic - Houston - Business Center Drive /ID# 254053

Houston, Texas, United States

Site Status

Accurate Clinical Research - Houston /ID# 254647

Houston, Texas, United States

Site Status

R & H Clinical Research - 777 Katy /ID# 255024

Katy, Texas, United States

Site Status

West Texas Clinical Research /ID# 253736

Lubbock, Texas, United States

Site Status

Trinity Universal Research Associates, Inc /ID# 253995

Plano, Texas, United States

Site Status

Sun Research Institute /ID# 255019

San Antonio, Texas, United States

Site Status

Advanced Rheumatology of Houston /ID# 254003

The Woodlands, Texas, United States

Site Status

DM Clinical Research - Tomball /ID# 254001

Tomball, Texas, United States

Site Status

Rheumatology Clinic of Houston /ID# 254002

Tomball, Texas, United States

Site Status

Aurora Rheumatology and Immunotherapy Center /ID# 254049

Franklin, Wisconsin, United States

Site Status

Rheumatic Disease Center, LLP /ID# 254015

Glendale, Wisconsin, United States

Site Status

Organizacion Medica de Investigacion (OMI) /ID# 253253

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina

Site Status

Consultorios Reumatologicos Pampa /ID# 254095

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina

Site Status

Aprillus Asistencia e Investigacion /ID# 253258

Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., Argentina

Site Status

Centro de Investigaciones Medicas Tucuman /ID# 253297

San Miguel de Tucumán, Tucumán Province, Argentina

Site Status

CIMER Centro Integral de Medicina Respiratoria /ID# 255277

San Miguel de Tucumán, Tucumán Province, Argentina

Site Status

ReumaClinic /ID# 252277

Genk, Limburg, Belgium

Site Status

UZ Gent /ID# 252306

Ghent, Oost-Vlaanderen, Belgium

Site Status

AZ Sint-Jan Brugge /ID# 252278

Bruges, West-Vlaanderen, Belgium

Site Status

Duplicate_CHU de Liege /ID# 252309

Liège, , Belgium

Site Status

CMiP - Centro Mineiro de Pesquisa Ltda - ME /ID# 254203

Juiz de Fora, Minas Gerais, Brazil

Site Status

CETI - Centro de Estudos em Terapias Inovadoras /ID# 254201

Curitiba, Paraná, Brazil

Site Status

Hospital de Clinicas de Porto Alegre /ID# 254916

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

LMK Sevicos Medicos S/S /ID# 254202

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 254917

São José do Rio Preto, São Paulo, Brazil

Site Status

CEPIC - Centro Paulista de Investigacao Clinica /ID# 254200

São Paulo, , Brazil

Site Status

Diagnostic Consultative Centre (Dcc) - Foкus 5 /ID# 252354

Sofiya, Sofia, Bulgaria

Site Status

Diagnostic Consultative Centre (Dcc) - Foкus 5 /ID# 252555

Sofiya, Sofia, Bulgaria

Site Status

Umbal Kaspela /ID# 252343

Plovdiv, , Bulgaria

Site Status

Medical center Unimed /ID# 252344

Plovdiv, , Bulgaria

Site Status

MHAT Plovdiv /ID# 252342

Plovdiv, , Bulgaria

Site Status

Diagnostic consultative center 17 Sofia /ID# 252341

Sofia, , Bulgaria

Site Status

Military Medical Academy Multiprofile Hospital /ID# 252355

Sofia, , Bulgaria

Site Status

Manitoba Clinic /ID# 254019

Winnipeg, Manitoba, Canada

Site Status

Centre Rhumatologie de l'Est /ID# 254932

Rimouski, Quebec, Canada

Site Status

Groupe de Recherche en Maladies Osseuses Inc /ID# 253409

Sainte-Foy, Quebec, Canada

Site Status

Centre de Recherche Musculo-Squelettique /ID# 256273

Trois-Rivières, Quebec, Canada

Site Status

Dr. Latha Naik Medical Professional Corporation /ID# 254018

Saskatoon, Saskatchewan, Canada

Site Status

Corporacion de Beneficiencia Osorno /ID# 252556

Osorno, Los Lagos Region, Chile

Site Status

Centro Internacional de Estudios Clinicos - CIEC /ID# 252561

Santiago, Region Metropolitana Santiago, Chile

Site Status

Clinica Dermacross /ID# 252560

Vitacura, Region Metropolitana Santiago, Chile

Site Status

Complejo Asistencial Dr. Sotero del Rio /ID# 252559

Santiago, Santiago Metropolitan, Chile

Site Status

The first affiliated hospital of bengbu medical college /ID# 252612

Bengbu, Anhui, China

Site Status

Peking University First Hospital /ID# 252392

Beijing, Beijing Municipality, China

Site Status

Peking University Third Hospital /ID# 252393

Beijing, Beijing Municipality, China

Site Status

The Third Affiliated Hospital, Sun Yat-Sen University /ID# 252394

Guangzhou, Guangdong, China

Site Status

Zhuzhou Central Hospital /ID# 252390

Zhuzhou, Hunan, China

Site Status

Nanjing Drum Tower Hospital /ID# 252613

Nanjing, Jiangsu, China

Site Status

Jiangxi Pingxiang Peoples Hospital /ID# 252381

Pingxiang, Jiangxi, China

Site Status

West China Hospital, Sichuan University /ID# 252364

Chengdu, Sichuan, China

Site Status

Hospital Pablo Tobón Uribe /ID# 253371

Medellín, Antioquia, Colombia

Site Status

Centro Integral de Reumatología del Caribe SAS - Circaribe SAS /ID# 252587

Barranquilla, Atlántico, Colombia

Site Status

Centro de Investigacion en Reumatologia y especialidades Medicas S.A.S- CIREEM /ID# 252586

Bogotá, Cundinamarca, Colombia

Site Status

Healthy Medical Center S.A.S /ID# 252585

Zipaquirá, Cundinamarca, Colombia

Site Status

Fundacion Oftalmologica de Santander - FOSCAL /ID# 252589

Bucaramanga, Santander Department, Colombia

Site Status

Medical Center Kuna-Peric /ID# 252452

Zagreb, City of Zagreb, Croatia

Site Status

Poliklinika Bonifarm /ID# 252741

Zagreb, City of Zagreb, Croatia

Site Status

Poliklinika Repromed /ID# 252451

Zagreb, City of Zagreb, Croatia

Site Status

Poliklinika Solmed /ID# 252453

Zagreb, City of Zagreb, Croatia

Site Status

Duplicate_Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice /ID# 252455

Krapinske Toplice, , Croatia

Site Status

Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 254224

Nice, Alpes-Maritimes, France

Site Status

CHU Toulouse - Hopital Purpan /ID# 252402

Toulouse, Haute-Garonne, France

Site Status

CHU Montpellier - Hôpital Lapeyronie /ID# 252386

Montpellier, Herault, France

Site Status

CHU Amiens-Picardie Site Sud /ID# 252384

Amiens, Somme, France

Site Status

Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 252385

Orléans, , France

Site Status

Hôpital Charles-Nicolle /ID# 252908

Rouen, , France

Site Status

Rheumatologische-Immunologische Praxis Templin /ID# 252863

Templin, Brandenburg, Germany

Site Status

Rheumazentrum Ruhrgebiet /ID# 252670

Herne, North Rhine-Westphalia, Germany

Site Status

MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH /ID# 252667

Hamburg, , Germany

Site Status

Klinische Forschung im med. Versorgungsalltag GbR /ID# 254221

Planegg, , Germany

Site Status

Rheumazentrum Ratingen /ID# 252669

Ratingen, , Germany

Site Status

General Hospital of Athens Laiko /ID# 252258

Athens, Attica, Greece

Site Status

University General Hospital Attikon /ID# 254751

Athens, Attica, Greece

Site Status

University General Hospital of Heraklion PA.G.N.I /ID# 252261

Heraklion, Crete, Greece

Site Status

Vital-Medicina Kft. /ID# 252399

Veszprém, Fejér, Hungary

Site Status

Betegapolo Irgalmasrend Budai Irgalmasrendi Korhaz /ID# 253311

Budapest, , Hungary

Site Status

CMED Rehabilitacios es Diagnosztikai Kozpont /ID# 252400

Székesfehérvár, , Hungary

Site Status

MÁV Kórház /ID# 252628

Szolnok, , Hungary

Site Status

Azienda Ospedaliero Universitaria Careggi /ID# 252460

Florence, Firenze, Italy

Site Status

ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 252461

Milan, Milano, Italy

Site Status

Azienda Ospedaliero Universitaria delle Marche /ID# 252459

Ancona, , Italy

Site Status

Japan Organization of Occupational Health and Safety Chubu Rosai Hospital /ID# 252836

Nagoya, Aichi-ken, Japan

Site Status

Daido Clinic - Nagoya /ID# 253058

Nagoya, Aichi-ken, Japan

Site Status

Kashiwa Kousei General Hospital /ID# 270033

Kashiwa-shi, Chiba, Japan

Site Status

Sugimoto Rheumatology and Internal Medicine Clinic /ID# 252774

Fukui-shi, Fukui, Japan

Site Status

Hamanomachi Hospital /ID# 253168

Fukuoka, Fukuoka, Japan

Site Status

Shono Rheumatism Clinic /ID# 252591

Fukuoka, Fukuoka, Japan

Site Status

Katayama Orthopedic Rheumatology Clinic /ID# 252746

Asahikawa-shi, Hokkaido, Japan

Site Status

Sagawa Akira Rheumatology Clin /ID# 252773

Sapporo, Hokkaido, Japan

Site Status

Hokkaido Medical Center For Rheumatic Diseases /ID# 270019

Sapporo, Hokkaido, Japan

Site Status

Matsubara Mayflower Hospital /ID# 252834

Kato-shi, Hyōgo, Japan

Site Status

Sanuki Municipal Hospital /ID# 252747

Sanuki-shi, Kagawa-ken, Japan

Site Status

Bay Side Misato Medical Center /ID# 252661

Kochi, Kochi, Japan

Site Status

Kumamoto Orthopaedic Hospital /ID# 253167

Kumamoto, Kumamoto, Japan

Site Status

Medical Corporation Keiai Kai Clinic /ID# 252750

Miyazaki, Miyazaki, Japan

Site Status

Sasebo Chuo Hospital /ID# 252662

Sasebo-shi, Nagasaki, Japan

Site Status

Rinku Hashimoto Rheumatology Orthopaedics /ID# 270396

Izumisano, Osaka, Japan

Site Status

St. Lukes International Hospital /ID# 253131

Chuo-ku, Tokyo, Japan

Site Status

Keio University Hospital /ID# 253205

Shinjuku-ku, Tokyo, Japan

Site Status

Tokito Clinic Rheumatology and Orthopaedics Surgery /ID# 253057

Shimonoseki-shi, Yamaguchi, Japan

Site Status

Maeshima Rheumatology Clinic /ID# 270448

Ōita, , Japan

Site Status

Toyama Prefectural Central Hospital /ID# 270871

Toyama, , Japan

Site Status

Centro Integral en Reumatologia S.A de C.V /ID# 252872

Guadalajara, Jalisco, Mexico

Site Status

Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 253480

Guadalajara, Jalisco, Mexico

Site Status

Hospital de Jesus /ID# 253114

Mexico City, Mexico City, Mexico

Site Status

CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 252873

Mexico City, Mexico City, Mexico

Site Status

Investigacion y Biomedicina de Chihuahua /ID# 253115

Chihuahua City, , Mexico

Site Status

Hospital Garcia de Orta /ID# 252491

Almada, Setúbal District, Portugal

Site Status

Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 252489

Ponte de Lima, Viana do Castelo District, Portugal

Site Status

Unidade Local de Saude de Santa Maria, EPE /ID# 252492

Lisbon, , Portugal

Site Status

GCM Medical Group PSC /ID# 252700

San Juan, , Puerto Rico

Site Status

Mindful Medical Research /ID# 252693

San Juan, , Puerto Rico

Site Status

Cabinet Medical Dr. Avram S.R.L /ID# 254133

Timișoara, Timiș County, Romania

Site Status

Banat Carina Med SRL /ID# 252757

Timișoara, Timiș County, Romania

Site Status

Spitalul Judetean de Urgenta Bacau /ID# 252860

Bacau, , Romania

Site Status

Spitalul Clinic Sf. Maria /ID# 252759

Bucharest, , Romania

Site Status

Spitalul Clinic Sf. Maria /ID# 253334

Bucharest, , Romania

Site Status

Institute for Rheumatology /ID# 252333

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 252334

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 252335

Belgrade, Beograd, Serbia

Site Status

Institute for Rheumatology /ID# 252338

Belgrade, Beograd, Serbia

Site Status

Special Hospital for Rheuma /ID# 252336

Novi Sad, Vojvodina, Serbia

Site Status

Special Hospital for Rheuma /ID# 252339

Novi Sad, Vojvodina, Serbia

Site Status

University of Pretoria /ID# 252368

Pretoria, Gauteng, South Africa

Site Status

Dr Elsa van Duuren /ID# 252387

Pretoria, Gauteng, South Africa

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Emmed Research cc /ID# 254317

Pretoria, Gauteng, South Africa

Site Status

Dr Asokan Naidoo /ID# 252894

Umhlanga, KwaZulu-Natal, South Africa

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Winelands Medical Research - Somerset West /ID# 252745

Cape Town, Western Cape, South Africa

Site Status

Arthritis Clinical Research Trials /ID# 252370

Cape Town, Western Cape, South Africa

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Winelands Medical Research Centre /ID# 252369

Stellenbosch, Western Cape, South Africa

Site Status

SoonChunHyang University Hospital Cheonan /ID# 254942

Cheonan-si, Chungcheongnam-do, South Korea

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Chungnam National University Hospital /ID# 252159

Daejeon, Daejeon Gwang Yeogsi, South Korea

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Chonnam National University Bitgoeul Hospital /ID# 254802

Gwangju, Gwangju Gwang Yeogsi, South Korea

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Seoul National University Hospital /ID# 252160

Seoul, Seoul Teugbyeolsi, South Korea

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Hanyang University Seoul Hospital /ID# 252161

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 252430

Santiago de Compostela, A Coruna, Spain

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Hospital Marina Baixa /ID# 254141

Villajoyosa, Alicante, Spain

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Hospital Universitario Germans Trias i Pujol /ID# 254144

Badalona, Barcelona, Spain

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Consorci Corporacio Sanitaria Parc Tauli Sabadell /ID# 252425

Sabadell, Barcelona, Spain

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Hospital Universitario y Politecnico La Fe /ID# 254143

Valencia, , Spain

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Royal Free Hospital /ID# 252297

London, Greater London, United Kingdom

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The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 252301

Kings Lynn, Norfolk, United Kingdom

Site Status

Queen Mary University of London /ID# 252671

London, , United Kingdom

Site Status

Portsmouth Hospitals University NHS Trust /ID# 252772

Portsmouth, , United Kingdom

Site Status

Countries

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United States Argentina Belgium Brazil Bulgaria Canada Chile China Colombia Croatia France Germany Greece Hungary Italy Japan Mexico Portugal Puerto Rico Romania Serbia South Africa South Korea Spain United Kingdom

Related Links

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Other Identifiers

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2022-502578-18-00

Identifier Type: OTHER

Identifier Source: secondary_id

M23-700

Identifier Type: -

Identifier Source: org_study_id