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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05110937 | RECRUITING
450 Participants

Dysfunctional Myelopoiesis and Myeloid-Derived Suppressor Cells in Sepsis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-01-04
Completion: 2026-07-31
Conditions
Sepsis Trauma Injury
Interventions
OTHER
No Results Yet
NCT05101317 | COMPLETED | PHASE2
142 Participants

A Study to Assess the Efficacy and Safety of HMI-115 in Subjects With Endometriosis-Associated Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-11
Completion: 2024-09-26
Conditions
Endometriosis
Interventions
DRUG
Results Available
NCT05100095 | RECRUITING | PHASE2
52 Participants

Hypofractionated Radiation Therapy for Merkel Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-12-14
Completion: 2028-09-01
Conditions
Merkel Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT05099003 | RECRUITING | PHASE1/PHASE2
132 Participants

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-05-31
Completion: 2027-06-30
Conditions
Malignant Glioma
Interventions
PROCEDURE RADIATION DRUG
No Results Yet
NCT05096897 | COMPLETED
138 Participants

Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2023-01-05
Completion: 2023-12-01
Conditions
Inflammatory Bowel Diseases Periodontitis Dental Caries Tooth Loss
Interventions
OTHER
No Results Yet
NCT05075993 | ACTIVE_NOT_RECRUITING | PHASE1
352 Participants

Study of LVGN3616 and LVGN6051±LVGN7409 in Combination With Nab-Paclitaxel or Bevacizumab and Cyclophosphamide in Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-11-12
Completion: 2027-02-02
Conditions
Metastatic Esophageal Gastric Cancer Metastatic Head and Neck Carcinoma Metastatic Hepatocellular Carcinoma Metastatic HPV Related Solid Tumors Metastatic Ovarian Carcinoma Metastatic Soft Tissue Sarcoma Metastatic Uveal Melanoma
Interventions
DRUG
No Results Yet
NCT05065424 | SUSPENDED | PHASE4
58 Participants

Premedication for Less Invasive Surfactant Administration Study (PRELISA)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-04-06
Completion: 2025-07-01
Conditions
Respiratory Distress Syndrome, Newborn
Interventions
DRUG
No Results Yet
NCT05063110 | COMPLETED | PHASE2
35 Participants

Treatment of Non Severe Hemophagocytosis Lymphohistiocytosis With ITACITINIB

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-05-03
Completion: 2025-04-03
Conditions
Adults Patients Having Non Severe HLH
Interventions
DRUG
No Results Yet
NCT05058651 | RECRUITING | PHASE2/PHASE3
189 Participants

Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-28
Completion: 2028-10-01
Conditions
Advanced Extrapulmonary Neuroendocrine Carcinoma Metastatic Extrapulmonary Neuroendocrine Carcinoma Recurrent Extrapulmonary Neuroendocrine Carcinoma Unresectable Extrapulmonary Neuroendocrine Carcinoma
Interventions
BIOLOGICAL PROCEDURE DRUG OTHER
No Results Yet
NCT05056857 | RECRUITING
290 Participants

Neutrophil Extracellular Traps Formation in Breast Cancer Patients Taking Tamoxifen

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-01
Completion: 2026-10-31
Conditions
Breast Carcinoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05031780 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
286 Participants

A Study Evaluating the Efficacy and Safety of Mitapivat (AG-348) in Participants With Sickle Cell Disease (RISE UP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-02-11
Completion: 2025-10-30
Conditions
Sickle Cell Disease
Interventions
DRUG OTHER
No Results Yet
NCT05031507 | RECRUITING
100 Participants

Study of Skeletal Disorders

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-01-18
Completion: 2025-12-31
Conditions
Skeletal Disorders
No Results Yet
NCT05025358 | COMPLETED | PHASE1
68 Participants

A Study of LP-118 in Patients With Advanced Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-09-08
Completion: 2025-07-09
Conditions
Solid Tumor Lymphoma, Non-Hodgkin
Interventions
DRUG
No Results Yet
NCT05019716 | RECRUITING | PHASE1
36 Participants

Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-13
Completion: 2026-06-30
Conditions
Advanced NUT Carcinoma Metastatic NUT Carcinoma Unresectable NUT Carcinoma
Interventions
DRUG PROCEDURE
No Results Yet
NCT05007834 | RECRUITING
50 Participants

Metabolism, Circadian Rhythms and Ovarian Function

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-02-24
Completion: 2026-06-30
Conditions
Chemotherapy-Induced Amenorrhea
No Results Yet
NCT05005039 | RECRUITING
40 Participants

Bone Marrow Fat and Bariatric Surgery-Mediated Bone Loss

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-04-20
Completion: 2026-06-30
Conditions
Bariatric Surgery in Postmenopausal Women
No Results Yet
NCT04989179 | ACTIVE_NOT_RECRUITING
220 Participants

Incidence and Factors Affecting the Development and Outcome of Post Mastectomy Pain Syndrome

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-28
Completion: 2026-12-31
Conditions
Breast Cancer Post-mastectomy Pain Syndrome
No Results Yet
NCT04981509 | RECRUITING | PHASE2
65 Participants

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-06-10
Completion: 2027-12-31
Conditions
Hereditary Leiomyomatosis and Renal Cell Carcinoma Papillary Renal Cell Carcinoma Renal Cell Carcinoma Sporadic Papillary Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT04976322 | ENROLLING_BY_INVITATION | PHASE3
760 Participants

A Study to Evaluate the Safety and Tolerability of Dapirolizumab Pegol in Study Participants With Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-07-27
Completion: 2030-08-07
Conditions
Systemic Lupus Erythematosus
Interventions
DRUG
No Results Yet
NCT04963153 | ACTIVE_NOT_RECRUITING | PHASE1
30 Participants

Testing Combination Erdafitinib and Enfortumab Vedotin in Metastatic Bladder Cancer After Treatment With Chemotherapy and Immunotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-07-07
Completion: 2026-12-01
Conditions
Locally Advanced Bladder Urothelial Carcinoma Locally Advanced Renal Pelvis Urothelial Carcinoma Locally Advanced Ureter Urothelial Carcinoma Locally Advanced Urethral Urothelial Carcinoma Locally Advanced Urothelial Carcinoma Metastatic Bladder Urothelial Carcinoma Metastatic Renal Pelvis Urothelial Carcinoma Metastatic Ureter Urothelial Carcinoma Metastatic Urethral Urothelial Carcinoma Metastatic Urothelial Carcinoma Recurrent Bladder Urothelial Carcinoma Recurrent Renal Pelvis Urothelial Carcinoma Recurrent Ureter Urothelial Carcinoma Recurrent Urethral Urothelial Carcinoma Recurrent Urothelial Carcinoma Stage IIIB Bladder Cancer AJCC v8 Stage IV Bladder Cancer AJCC v8 Stage IV Renal Pelvis Cancer AJCC v8 Stage IV Ureter Cancer AJCC v8 Stage IV Urethral Cancer AJCC v8
Interventions
PROCEDURE DRUG
No Results Yet
NCT04960826 | RECRUITING
100 Participants

Study of an Environmental Risk Factor in Crohn's Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-09-27
Completion: 2026-07-31
Conditions
Inflammatory Bowel Diseases
No Results Yet
NCT04946851 | ENROLLING_BY_INVITATION
1400 Participants

Addictions Neuroclinical Assessment (ANA)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-08-12
Completion: 2031-12-31
Conditions
Normal Physiology Alcohol Use Disorder
No Results Yet
NCT04943861 | RECRUITING | NA
200 Participants

Human Immunodeficiency Virus (HIV) Food Insecurities

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2023-12-01
Completion: 2026-02-28
Conditions
Food Insecurities Cardiometabolic Comorbidities HIV PreDiabetes Type 2 Diabetes Mellitus (T2DM)
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT04939051 | SUSPENDED | PHASE2
30 Participants

Obeticholic Acid for Prevention in Barrett's Esophagus

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2024-01-03
Completion: 2027-09-01
Conditions
Barrett Esophagus Esophageal Adenocarcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG OTHER
No Results Yet
NCT04933539 | ACTIVE_NOT_RECRUITING | PHASE2
14 Participants

Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-10-31
Completion: 2026-07-26
Conditions
Multiple Myeloma
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT04930029 | RECRUITING
320 Participants

Evaluation of Long-term Adverse Effects of Gastric Bypass in Omega

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-09-15
Completion: 2026-07-31
Conditions
Bypass Complication Obesity
Interventions
OTHER
No Results Yet
NCT04929041 | RECRUITING | PHASE2/PHASE3
427 Participants

Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) for Advanced Stage Non-small Cell Lung Cancer Patients Who Are PD-L1 Negative

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-10-07
Completion: 2027-12-31
Conditions
Lung Adenocarcinoma Lung Adenosquamous Carcinoma Lung Non-Small Cell Carcinoma Stage IIIB Lung Cancer AJCC v8 Stage IIIC Lung Cancer AJCC v8 Stage IV Lung Cancer AJCC v8
Interventions
PROCEDURE BIOLOGICAL OTHER RADIATION
No Results Yet
NCT04927416 | RECRUITING | PHASE2
54 Participants

The Role of 68-Gallium-DOTATATE-PET/CT in the Imaging of Metastatic Thyroid Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-25
Completion: 2030-11-30
Conditions
Metastic Thyroid Cancer
Interventions
DRUG
No Results Yet
NCT04917536 | COMPLETED | NA
80 Participants

Comparison of the Speed of Functional Recovery (Constant Score) Between Two Different Approaches of Humeral Nailing in Humeral Fractures: Through the Rotator Cuff or Through the Rotator Interval Split (HUNAAP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-06-21
Completion: 2025-06-01
Conditions
Humeral Upper Extremity Fracture Humeral Diaphysis Fracture
Interventions
PROCEDURE
No Results Yet
NCT04897776 | COMPLETED | NA
5 Participants

Stimulation of the Thalamus for Arousal Restoral in Temporal Lobe Epilepsy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-31
Completion: 2025-06-16
Conditions
Epilepsy, Temporal Lobe
Interventions
DEVICE
No Results Yet
NCT04896060 | COMPLETED
5056 Participants

The Impact of the COVID-19 Pandemic on Eating Behavior and Weight Change

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-09-01
Completion: 2025-02-13
Conditions
COVID-19 Obesity
No Results Yet
NCT04888052 | COMPLETED | NA
6 Participants

Prolonged Preoperative Rehabilitation in ACL Rupture.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-10-19
Completion: 2022-12-31
Conditions
Anterior Cruciate Ligament Injuries
Interventions
DEVICE
No Results Yet
NCT04872543 | RECRUITING | PHASE2
25 Participants

A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-04-29
Completion: 2026-04-30
Conditions
Malignant Peripheral Nerve Sheath Tumors (MPNST)
Interventions
DRUG
No Results Yet
NCT04858334 | RECRUITING | PHASE2
152 Participants

APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2021-06-22
Completion: 2027-10-31
Conditions
Pancreatic Acinar Cell Carcinoma Pancreatic Adenosquamous Carcinoma Pancreatic Squamous Cell Carcinoma Resectable Pancreatic Acinar Cell Carcinoma Resectable Pancreatic Adenocarcinoma Resectable Pancreatic Adenosquamous Carcinoma Resectable Pancreatic Carcinoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT04852926 | COMPLETED
25 Participants

Study of the Sexual Health of Patients Treated for Breast Cancer and Followed up in the Observatory of Fertility at Jeanne de Flandre Hospital.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-07-13
Completion: 2025-06-13
Conditions
Breast Cancer Breast Neoplasms Breast Carcinoma Breast Tumor
Interventions
OTHER
No Results Yet
NCT04847453 | SUSPENDED | PHASE1
24 Participants

Venetoclax, MLN9708 (Ixazomib Citrate) and Dexamethasone for the Treatment of Relapsed or Refractory Light Chain Amyloidosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-08-03
Completion: 2026-06-30
Conditions
AL Amyloidosis
Interventions
PROCEDURE DRUG
No Results Yet
NCT04845165 | COMPLETED
25 Participants

Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2022-04-19
Completion: 2023-11-09
Conditions
Familial Partial Lipodystrophy Type 2
Interventions
OTHER
No Results Yet
NCT04840602 | SUSPENDED | PHASE2
92 Participants

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib and Rituximab) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-26
Start Date: 2022-01-05
Completion: 2028-03-31
Conditions
Lymphoplasmacytic Lymphoma Waldenstrom Macroglobulinemia
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04830709 | RECRUITING
750 Participants

Non-interventional Study to Collect Real-world Clinical and Patient-reported Outcomes in Ovarian Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2021-06-15
Completion: 2033-03-31
Conditions
Ovarian Cancer
No Results Yet
NCT04799496 | COMPLETED
688 Participants

A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-26
Start Date: 2020-06-10
Completion: 2025-06-30
Conditions
Colitis, Ulcerative Crohn Disease Inflammatory Bowel Diseases
No Results Yet
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