Clinical Trials Updated in 2025

NCT06312176 | RECRUITING | PHASE3

1200 Participants

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-14

Completion: 2027-07-11

Conditions

Breast Neoplasms

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT06312137 | RECRUITING | PHASE3

780 Participants

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-03

Completion: 2034-02-21

Conditions

Non Small Cell Lung Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06305767 | RECRUITING | PHASE1/PHASE2

230 Participants

A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-28

Completion: 2027-04-23

Conditions

Bladder Cancer

Interventions

BIOLOGICAL OTHER PROCEDURE

No Results Yet

NCT06305754 | RECRUITING | PHASE3

520 Participants

Sacituzumab Tirumotecan (MK-2870) Versus Pemetrexed and Carboplatin Combination Therapy in Participants With Epidermal Growth Factor (EGFR)-Mutated, Advanced Nonsquamous Non-small Cell Lung Cancer (NSCLC) Who Have Progressed on Prior EGFR Tyrosine Kinase Inhibitors (MK-2870-009)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-11

Completion: 2028-09-12

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06299540 | RECRUITING

180 Participants

Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-27

Completion: 2026-09-30

Conditions

Leukemia, Lymphocytic, Chronic, B-Cell

Interventions

BEHAVIORAL DRUG

No Results Yet

NCT06298227 | RECRUITING | NA

60 Participants

Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-11

Completion: 2026-03-30

Conditions

Kidney Diseases Kidney Failure

Interventions

OTHER

No Results Yet

NCT06297603 | ACTIVE_NOT_RECRUITING | PHASE3

320 Participants

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-15

Completion: 2026-10-31

Conditions

Type 2 Diabetes

Interventions

DRUG

No Results Yet

NCT06293521 | RECRUITING | PHASE2

40 Participants

Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-01

Completion: 2026-01-31

Conditions

Deep Caries

Interventions

PROCEDURE

No Results Yet

NCT06292000 | WITHDRAWN | NA

0 Participants

Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-01

Completion: 2026-06-30

Conditions

PreDiabetes Obesity Inactivity/Low Levels of Exercise

Interventions

BEHAVIORAL

No Results Yet

NCT06283251 | RECRUITING | NA

40 Participants

PediRISE Feasibility

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-15

Completion: 2025-12-31

Conditions

Pediatric Cancer Financial Stress Financial Hardship Disparities

Interventions

BEHAVIORAL

No Results Yet

NCT06275087 | RECRUITING | NA

42 Participants

Differences in Speed of Recovery From Anesthesia for Intraoral Surgery

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-10

Completion: 2025-11-05

Conditions

Intraoral Tumor

Interventions

DRUG

No Results Yet

NCT06256380 | RECRUITING | NA

200 Participants

Comparing Enhanced Cognitive-behavior Therapy and Family-based Treatment for Adolescents With an Eating Disorder

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-07

Completion: 2028-12-31

Conditions

Feeding and Eating Disorders

Interventions

BEHAVIORAL

No Results Yet

NCT06255990 | RECRUITING

42 Participants

Clinical and Histological Study of a Novel Dermal Substitute

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-15

Completion: 2026-06-01

Conditions

Skin Transplantation

Interventions

OTHER

No Results Yet

NCT06253507 | ENROLLING_BY_INVITATION | PHASE1/PHASE2

10 Participants

pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-25

Completion: 2027-03-31

Conditions

p47 Autosomal Recessive Chronic Granulomatous Disease

Interventions

BIOLOGICAL

No Results Yet

NCT06242678 | COMPLETED | NA

2 Participants

Evaluating Spinal Cord Stimulation for Stiff Person Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-11-01

Completion: 2025-08-21

Conditions

Stiff-Person Syndrome

Interventions

DEVICE

No Results Yet

NCT06238700 | RECRUITING | NA

80 Participants

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-14

Completion: 2027-07-31

Conditions

Depression

Interventions

DIETARY_SUPPLEMENT OTHER

No Results Yet

NCT06238544 | ACTIVE_NOT_RECRUITING | PHASE2

132 Participants

Long-term Safety and Tolerability of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-06

Completion: 2027-12-31

Conditions

Paroxysmal Nocturnal Hemoglobinuria

Interventions

DRUG

No Results Yet

NCT06227377 | RECRUITING | PHASE1

250 Participants

QTX3034 in Patients With KRAS G12D Mutation

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-05

Completion: 2027-04-01

Conditions

Solid Tumors

Interventions

DRUG COMBINATION_PRODUCT

No Results Yet

NCT06226883 | RECRUITING | PHASE2

210 Participants

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-18

Completion: 2026-11-30

Conditions

Inflammatory Bowel Diseases Crohn's Disease

Interventions

DRUG

No Results Yet

NCT06225596 | RECRUITING | PHASE2/PHASE3

956 Participants

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-24

Completion: 2030-12-31

Conditions

Metastatic Urothelial Cancer

Interventions

DRUG

No Results Yet

NCT06219408 | RECRUITING | NA

60 Participants

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2026-01-02

Completion: 2027-05-31

Conditions

Chronic Pain Posttraumatic Stress Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06218134 | COMPLETED | NA

3 Participants

Evaluate the Safety and Potential Efficacy of Human Wharton's Jelly-derived Mesenchymal Stem Cells With Charcot-Marie-Tooth Disease Type 1E

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-23

Completion: 2024-10-28

Conditions

Charcot-Marie-Tooth Disease, Type 1

Interventions

BIOLOGICAL

No Results Yet

NCT06211634 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

57 Participants

A Phase 1/2 Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of HMB-001 in Glanzmann Thrombasthenia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2022-12-13

Completion: 2027-08-31

Conditions

Glanzmann Thrombasthenia

Interventions

DRUG

No Results Yet

NCT06204887 | COMPLETED | NA

97 Participants

Effect of Irrigation-Activation Techniques on Healing in Large Periapical Lesions

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-11-01

Completion: 2023-02-27

Conditions

Effect of Irrigation Activation on Periapical Healing

Interventions

PROCEDURE

Results Available

NCT06189391 | RECRUITING | PHASE1

100 Participants

A Study to Evaluate MK-1045 (CN201) in Participants With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (MK-1045-001/CN201-101)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2021-03-16

Completion: 2027-03-31

Conditions

Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Interventions

DRUG

No Results Yet

NCT06188481 | COMPLETED | NA

66 Participants

Efficacy of Whole-body Electromyostimulation (WB-EMS) Training in Participants With Pre-diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-23

Completion: 2025-12-17

Conditions

Pre-diabetes

Interventions

OTHER

No Results Yet

NCT06184126 | RECRUITING | NA

30 Participants

Virtual Reality Devices as an Adjunct to Usual Care for Patients With Sickle Cell Disease Experiencing Vaso-Occlusive Crises

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-11-01

Completion: 2026-09-30

Conditions

Sickle Cell Disease Vaso-occlusive Pain Episode in Sickle Cell Disease Acute Pain

Interventions

DEVICE OTHER

No Results Yet

NCT06170788 | RECRUITING | PHASE3

614 Participants

Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab Versus Pembrolizumab Alone in Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥ 50% (MK-2870-007)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-15

Completion: 2028-01-25

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06170606 | RECRUITING | NA

200 Participants

POLARx Post Approval Study (POLARx PAS)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-28

Completion: 2026-05-31

Conditions

Paroxysmal Atrial Fibrillation

Interventions

DEVICE

No Results Yet

NCT06158841 | RECRUITING | PHASE3

380 Participants

Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-19

Completion: 2027-12-31

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT06155786 | COMPLETED | NA

36 Participants

Cognitive Effects of tDCS and tRNS in Schizophrenia

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-01-01

Completion: 2023-11-01

Conditions

Schizophrenia Cognitive Impairment

Interventions

DEVICE

No Results Yet

NCT06150157 | RECRUITING | PHASE1

220 Participants

A Study of JNJ-88549968 for the Treatment of Calreticulin (CALR)-Mutated Myeloproliferative Neoplasms

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-20

Completion: 2026-12-04

Conditions

Myeloproliferative Disorders Essential Thrombocythemia Neoplasms Myelofibrosis

Interventions

DRUG

No Results Yet

NCT06147258 | RECRUITING | NA

60 Participants

The Impact of Expressive Emotional Writing on Facilitating Grief Resolution in Adults With Spinal Cord Injury

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-03

Completion: 2026-12-31

Conditions

Spinal Cord Injuries Transverse Myelitis

Interventions

BEHAVIORAL

No Results Yet

NCT06144242 | ACTIVE_NOT_RECRUITING | NA

90 Participants

Improving Antibiotic Use for ARIs in Urgent Care Clinics

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-01

Completion: 2025-06-30

Conditions

Antibacterial Agents Ambulatory Care

Interventions

BEHAVIORAL

No Results Yet

NCT06143293 | RECRUITING | NA

144 Participants

RESEARCH EVALUATING VAGAL EXCITATION AND ANATOMICAL LINKS

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-15

Completion: 2026-08-01

Conditions

Epilepsy Depressive Disorder

Interventions

DEVICE

No Results Yet

NCT06142383 | TERMINATED | PHASE2

136 Participants

A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-12

Completion: 2024-11-01

Conditions

Heart Failure

Interventions

BIOLOGICAL DRUG

Results Available

NCT06142357 | ACTIVE_NOT_RECRUITING

199 Participants

Secukinumab Drug Survival, Effectiveness and Tolerability in Pediatric Patients With Psoriasis

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-29

Completion: 2027-08-31

Conditions

Moderate-to-severe Plaque Psoriasis

Interventions

OTHER

No Results Yet

NCT06141785 | RECRUITING | NA

200 Participants

Early Nutritional Intervention in Patients With Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-01

Completion: 2026-03-31

Conditions

Nutritional Intervention Cancer Malnutrition

Interventions

OTHER

No Results Yet

NCT06139406 | ACTIVE_NOT_RECRUITING | PHASE1

70 Participants

A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-06

Completion: 2026-01-30

Conditions

Lymphoma, Non-Hodgkin

Interventions

DRUG

No Results Yet

NCT06132958 | ACTIVE_NOT_RECRUITING | PHASE3

710 Participants

Sacituzumab Tirumotecan (MK-2870) in Post Platinum and Post Immunotherapy Endometrial Cancer (MK-2870-005)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2023-12-06

Completion: 2028-01-10

Conditions

Endometrial Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet