POLARx Post Approval Study (POLARx PAS)

NCT ID: NCT06170606

Last Updated: 2025-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-28

Study Completion Date

2029-05-31

Brief Summary

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To collect clinical data on safety, effectiveness and procedural success of Boston Scientific's Cardiac Cryoablation System (includes all BSC commercially available POLARx/POLARx Fit catheters) when used to perform pulmonary vein isolation (PVI) in the ablation treatment of de novo Atrial Fibrillation (AF).

Detailed Description

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Conditions

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Paroxysmal Atrial Fibrillation

Keywords

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Cryoablation

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

prospective, single arm study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cryoablation

Subjects undergoing cardiac ablation procedure with the Boston Scientific Cardiac Cryoablation System.

Group Type EXPERIMENTAL

Boston Scientific Cardiac Cryoablation System

Intervention Type DEVICE

The Boston Scientific Cardiac Cryoablation System is intended for ablation and electrical mapping of the pulmonary veins for pulmonary vein isolation (PVI) in the ablation treatment of patients with paroxysmal atrial fibrillation (PAF).The main devices and components of the system consists of the following:

* POLARx™ or POLARx™ FIT Cryoablation Catheter
* POLARMAP™ Catheter
* POLARSHEATH™
* SMARTFREEZE™ Console
* Diaphragm Movement Sensor (DMS)
* Related Accessories

Interventions

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Boston Scientific Cardiac Cryoablation System

The Boston Scientific Cardiac Cryoablation System is intended for ablation and electrical mapping of the pulmonary veins for pulmonary vein isolation (PVI) in the ablation treatment of patients with paroxysmal atrial fibrillation (PAF).The main devices and components of the system consists of the following:

* POLARx™ or POLARx™ FIT Cryoablation Catheter
* POLARMAP™ Catheter
* POLARSHEATH™
* SMARTFREEZE™ Console
* Diaphragm Movement Sensor (DMS)
* Related Accessories

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subjects indicated for drug refractory, recurrent symptomatic PAF treatment with the Cryoablation System, per physician's medical judgement, and as per standard of care
* Subjects who are willing and capable of providing informed consent;
* Subjects who are willing and capable of participating in all testing associated with this clinical study at an approved clinical investigational center;

Exclusion Criteria

* Any known contraindication to an AF ablation or anticoagulation, including those listed in the IFU as legally approved conditions;
* Any prior LA ablation;
* Known or pre-existing severe PV Stenosis;
* Subjects with severe valvular disease OR with a prosthetic - mechanical or biological - heart valve (not including valve repair and annular rings);
* Presence of any pulmonary vein stents;
* Subjects with active systemic infection;
* Subject is unable or not willing to complete follow-up visits and examination for the duration of the study;- Subjects with life expectancy ≤ 1 year per investigator's medical judgement;
* Women of childbearing potential who are, or plan to become, pregnant during the time of the study (assessment per investigator's discretion);
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Wilber W Su, MD,FACC,FHRS

Role: STUDY_CHAIR

Banner- University Medical Group- Heart Center, Phoenix, AZ, USA

Locations

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Mercy Gilbert Medical Center

Gilbert, Arizona, United States

Site Status RECRUITING

Banner University Medical Center Phoenix

Phoenix, Arizona, United States

Site Status ACTIVE_NOT_RECRUITING

Pima Heart & Vascular Clinical Research

Tucson, Arizona, United States

Site Status WITHDRAWN

Torrance Memorial Medical Center

Torrance, California, United States

Site Status RECRUITING

Intermountain Platte Valley Hospital

Brighton, Colorado, United States

Site Status WITHDRAWN

Valley View Hospital

Glenwood Springs, Colorado, United States

Site Status RECRUITING

St. Joseph's Hospital/BayCare Medical Group

Tampa, Florida, United States

Site Status WITHDRAWN

Bethesda North Hospital

Cincinnati, Ohio, United States

Site Status RECRUITING

Prisma Health Richland Hospital

Columbia, South Carolina, United States

Site Status ACTIVE_NOT_RECRUITING

University of Texas Medical Branch - Galveston

Galveston, Texas, United States

Site Status RECRUITING

Aurora Health

Grafton, Wisconsin, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Sharon Mensah

Role: CONTACT

Phone: 6124037653

Email: [email protected]

Facility Contacts

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Jacqueline Killian

Role: primary

Jaquelina Patti

Role: primary

Kim Williams

Role: primary

Adeteju Mowo-Wale

Role: primary

Lindsey Allen

Role: primary

Elizabeth Hennesey

Role: backup

Anthony Chambers

Role: primary

Mohamed Djelmami-Hani, MD

Role: backup

Other Identifiers

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PY008

Identifier Type: -

Identifier Source: org_study_id