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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06040086 | ACTIVE_NOT_RECRUITING | PHASE3
1454 Participants

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-09-22
Completion: 2026-03-02
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
DRUG
No Results Yet
NCT06036836 | ACTIVE_NOT_RECRUITING | PHASE2
160 Participants

Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-09-29
Completion: 2026-03-31
Conditions
Solid Tumor Cutaneous Squamous Cell Carcinoma Endometrial Cancer
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06033391 | COMPLETED | NA
94 Participants

Mobile App for Obsessive-compulsive Disorder in Adolescents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-04-09
Completion: 2024-05-24
Conditions
Obsessive-Compulsive Disorder in Adolescence
Interventions
DEVICE
No Results Yet
NCT06030063 | RECRUITING
5000 Participants

The Society for Obstetric Anesthesia and Perinatology Research Network General Anesthesia Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2024-02-22
Completion: 2026-12-31
Conditions
General Anesthesia Cesarean Delivery
No Results Yet
NCT06029595 | TERMINATED | PHASE2
517 Participants

Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-11-26
Completion: 2025-12-09
Conditions
Uncontrolled Asthma
Interventions
DRUG
No Results Yet
NCT06027814 | ACTIVE_NOT_RECRUITING | NA
40 Participants

MHealth Incentivized Adherence Plus Patient Navigation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-01-03
Completion: 2025-04-14
Conditions
Opioid Use Disorder Medication Adherence Polysubstance Drug Use (Indiscriminate Drug Use) Methamphetamine-dependence
Interventions
BEHAVIORAL
No Results Yet
NCT06015750 | WITHDRAWN | PHASE4
0 Participants

Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2026-07-29
Completion: 2030-03-13
Conditions
Hypophosphatasia
Interventions
DRUG
No Results Yet
NCT06005220 | COMPLETED | NA
143 Participants

SBD121, a Synbiotic Medical Food for RA Management

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-09-30
Completion: 2025-10-06
Conditions
Rheumatoid Arthritis
Interventions
OTHER
No Results Yet
NCT06001177 | COMPLETED | PHASE2
55 Participants

A Study of Efficacy, Safety, and Tolerability of KAN-101 in People With Celiac Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-12-13
Completion: 2025-01-03
Conditions
Celiac Disease Coeliac Disease
Interventions
DRUG
Results Available
NCT05998278 | RECRUITING | NA
330 Participants

Personalized Optimization of Systematic Prostate Biopsy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-23
Completion: 2025-12-30
Conditions
Prostate Adenocarcinoma
Interventions
PROCEDURE
No Results Yet
NCT05989230 | RECRUITING | NA
30 Participants

Emotional Awareness and Expression Therapy for People With Persistent Pain Following Orthopedic Trauma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-08-28
Completion: 2027-08-01
Conditions
Orthopaedic Trauma Chronic Pain Musculoskeletal Injury
Interventions
BEHAVIORAL
No Results Yet
NCT05983250 | RECRUITING | PHASE3
230 Participants

LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-01-10
Completion: 2026-10-31
Conditions
Pulmonary Hypertension
Interventions
DRUG
No Results Yet
NCT05974644 | NOT_YET_RECRUITING
1000 Participants

Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2026-02-28
Completion: 2030-12-01
Conditions
Amyloidosis, Hereditary
Interventions
OTHER
No Results Yet
NCT05964205 | ACTIVE_NOT_RECRUITING
9704 Participants

Analysis of a Stepped-Wedge Implementation of the PT-PENCIL Tool

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2023-07-18
Completion: 2024-06-01
Conditions
Physical Therapy Evaluation
Interventions
OTHER
No Results Yet
NCT05959655 | COMPLETED | NA
38 Participants

Modern Urodynamics System Efficacy (MUSE) Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-21
Completion: 2024-04-18
Conditions
Urologic Diseases Urodynamics
Interventions
DEVICE
Results Available
NCT05958342 | RECRUITING | PHASE2
1050 Participants

CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-06-30
Completion: 2027-03-31
Conditions
Trauma Hemorrhage
Interventions
DRUG
No Results Yet
NCT05957978 | COMPLETED | PHASE2
52 Participants

LXE408 for Treatment of Visceral Leishmaniasis in Ethiopia, a Proof of Concept Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-03-29
Completion: 2025-06-27
Conditions
Primary Visceral Leishmaniasis
Interventions
DRUG
No Results Yet
NCT05943444 | RECRUITING | NA
256 Participants

Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-08
Completion: 2027-08-08
Conditions
Rectal Neoplasms Low Anterior Resection Syndrome Anastomotic Leak Quality of Life
Interventions
PROCEDURE
No Results Yet
NCT05940350 | RECRUITING | NA
60 Participants

Telerehabilitation-Based Coaching Interventions (TeleSCoP) for Patients With Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2025-02-01
Completion: 2025-12-31
Conditions
Ischemic Stroke Coaching
Interventions
BEHAVIORAL
No Results Yet
NCT05926960 | ACTIVE_NOT_RECRUITING | PHASE2
38 Participants

A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-06-13
Completion: 2026-01-19
Conditions
Melanoma
Interventions
DRUG
No Results Yet
NCT05906446 | COMPLETED | NA
50 Participants

Post-acute Multicomponent Frailty Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-06-15
Completion: 2024-10-31
Conditions
Frailty
Interventions
OTHER
No Results Yet
NCT05902533 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
33 Participants

REDEL Trial: Reduced Elective Nodal Dose for Anal Cancer Toxicity Mitigation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-14
Completion: 2026-08-14
Conditions
Anal Cancer
Interventions
RADIATION DRUG
No Results Yet
NCT05894005 | RECRUITING | NA
44 Participants

The Use of Immersive 360-degree Video in Improving Spatial Orientation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2025-11-08
Completion: 2026-07-31
Conditions
Virtual Reality
Interventions
OTHER
No Results Yet
NCT05884476 | RECRUITING | NA
180 Participants

Randomized Clinical Trial of Re-Evaluating Suicidal Thoughts in Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-01-08
Completion: 2027-06-30
Conditions
Suicidal Ideation Suicide, Attempted
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT05883748 | ENROLLING_BY_INVITATION | PHASE2/PHASE3
230 Participants

HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-31
Completion: 2028-06-30
Conditions
Erythropoietic Protoporphyria
Interventions
DRUG
No Results Yet
NCT05875740 | COMPLETED
16 Participants

Correlation of Memory CD8+ T Cells With Sepsis Severity and Mortality: a Single-center, Unblinded, Prospective, Non-interventional, Observational Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2023-09-06
Completion: 2024-11-03
Conditions
Sepsis Inflammatory Response
No Results Yet
NCT05874037 | COMPLETED | PHASE2/PHASE3
191 Participants

Fluvoxamine for Long COVID-19

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-05-15
Completion: 2025-03-15
Conditions
Long COVID
Interventions
DRUG
No Results Yet
NCT05871125 | COMPLETED | NA
33 Participants

Identifying Ideal Reimbursement "Dose" to Reduce Clinical Trial-related Financial Toxicity

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-07-01
Completion: 2025-12-01
Conditions
Breast Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT05860296 | TERMINATED | PHASE1/PHASE2
36 Participants

Testing Experimental Anti-cancer Drug SLC-391 With an Approved Immunotherapy Drug, Pembrolizumab, for Advanced Lung Cancers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-05-31
Completion: 2025-12-01
Conditions
Lung Cancer, Nonsmall Cell Lung Cancer Stage IV Lung Cancer Metastatic
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05854667 | RECRUITING | PHASE2
440 Participants

Clinical Trial of High Dose Lisdexamfetamine and Contingency Management in MA Users

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-12-05
Completion: 2027-12-31
Conditions
Methamphetamine Abuse Methamphetamine-dependence Addiction, Substance Addiction
Interventions
DRUG
No Results Yet
NCT05850520 | COMPLETED | PHASE3
892 Participants

A Study to Learn How Well a Higher Amount of Aflibercept Given as an Injection Into the Eye Works and How Safe it is in People With Reduced Vision Due to Swelling in the Macula, Central Part of the Retina Caused by a Blocked Vein in the Retina (Macula Edema Secondary to Retinal Vein Occlusion)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-05-15
Completion: 2024-11-07
Conditions
Macular Edema Secondary to Retinal Vein Occlusion
Interventions
DRUG DIAGNOSTIC_TEST
Results Available
NCT05850416 | RECRUITING | NA
75 Participants

mGlide-Care: A Partnership With Caregivers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2025-12-15
Completion: 2028-05-30
Conditions
HTN
Interventions
OTHER
No Results Yet
NCT05850364 | COMPLETED | PHASE3
1442 Participants

A Multi-center, Open-labelled, Randomized, Controlled, Extended Phase â…¢ Clinical Trial of sIPV Vaccine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-05-22
Completion: 2025-02-13
Conditions
Poliomyelitis Polio
Interventions
BIOLOGICAL
No Results Yet
NCT05842954 | COMPLETED | PHASE3
1720 Participants

Efficacy, Safety and Tolerability of KLU156 in Adults and Children With Uncomplicated P. Falciparum Malaria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2024-03-07
Completion: 2025-06-27
Conditions
Uncomplicated Plasmodium Falciparum Malaria
Interventions
DRUG
No Results Yet
NCT05838677 | COMPLETED | NA
380 Participants

Pain at Work Toolkit in Employees With Chronic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-07-01
Completion: 2025-07-22
Conditions
Chronic Pain Pain, Chronic
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05837936 | RECRUITING
600 Participants

Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2023-03-28
Completion: 2028-03-31
Conditions
Extubation
Interventions
OTHER
No Results Yet
NCT05836324 | RECRUITING | PHASE1
408 Participants

A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-07-24
Completion: 2027-01-13
Conditions
Solid Tumors Advanced Solid Tumors Metastatic Solid Tumors
Interventions
DRUG
No Results Yet
NCT05834725 | ACTIVE_NOT_RECRUITING | NA
260 Participants

Resilience Coaching for Adolescents With Chronic Musculoskeletal Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-05-08
Completion: 2025-11-02
Conditions
Pain, Chronic Pain Syndrome Psychological
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05829330 | RECRUITING | NA
46 Participants

Ambulatory Versus Inpatient Initiation of Home Mechanical Ventilation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-09-20
Completion: 2026-02-28
Conditions
Amyotrophic Lateral Sclerosis
Interventions
OTHER
No Results Yet
NCT05822544 | RECRUITING | PHASE1
564 Participants

Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-04-22
Completion: 2026-02-28
Conditions
Healthy Subjects Obesity Type 2 Diabetes
Interventions
DRUG OTHER
No Results Yet
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