Clinical Trials

Showing trials with last updates posted in 2025.

NCT04603820 | ACTIVE_NOT_RECRUITING
866 Participants

Registry Study of Pregnancy and Breast Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2019-11-18
Completion: 2030-01-31
Conditions
Breast Cancer and Pregnancy
No Results Yet
NCT04582682 | ACTIVE_NOT_RECRUITING
750 Participants

Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2021-01-18
Completion: 2025-11-01
Conditions
Concussion, Mild
No Results Yet
NCT04570423 | RECRUITING | PHASE2
40 Participants

A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-05-20
Completion: 2027-10-31
Conditions
Solid Tumors Lymphoma
Interventions
DRUG
No Results Yet
NCT04566185 | COMPLETED | NA
14 Participants

Evaluation of the Predictive Value of 18F-fluorodeoxyglucose Positron Emission Tomography and Brain Perfusion Computed Tomography for the Efficacy of Anti-angiogenic Therapy (Bevacizumab) in Recurrent Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-12-16
Completion: 2023-06-27
Conditions
Glioblastoma
Interventions
OTHER
No Results Yet
NCT04550728 | RECRUITING | PHASE1/PHASE2
60 Participants

Hybrid Robot+FES Stroke Rehabilitation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-08-01
Completion: 2026-10-01
Conditions
Stroke
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04548661 | COMPLETED | NA
2701 Participants

Clinical Evaluation of Adults Undergoing Elective Surgery Utilizing Intraoperative Incisional Wound Irrigation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-08-02
Completion: 2025-09-30
Conditions
Surgical Site Infection
Interventions
PROCEDURE
No Results Yet
NCT04547686 | COMPLETED | NA
918 Participants

Efficacy of a Smoke-Free Homes Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-11-11
Completion: 2025-07-27
Conditions
Cessation, Smoking
Interventions
BEHAVIORAL
No Results Yet
NCT04543201 | RECRUITING | NA
50 Participants

Telehealth Visits to Discuss Advanced Directives for Patients Newly Diagnosed With High Grade Glioma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-10-08
Completion: 2026-07-31
Conditions
Glioma
Interventions
BEHAVIORAL
No Results Yet
NCT04541082 | RECRUITING | PHASE1
102 Participants

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-10-26
Completion: 2026-07-31
Conditions
Central Nervous System Neoplasms Glioblastoma Gliosarcoma, Adult Anaplastic Oligodendroglioma Anaplastic Astrocytoma Pilocytic Astrocytoma Oligodendroglioma Gliomatosis Cerebri Pleomorphic Xanthoastrocytoma Anaplastic Pleomorphic Xanthoastrocytoma Diffuse Midline Glioma, H3 K27M-Mutant Ependymoma Ependymoma, Anaplastic Medulloblastoma Teratoid Rhabdoid Tumor Neuroectodermal Tumors, Primitive Neuroectodermal Tumors Anaplastic Meningioma Atypical Meningioma Choroid Plexus Neoplasms Pineal Tumor Diffuse Astrocytoma Glial Tumor
Interventions
DRUG
No Results Yet
NCT04529070 | TERMINATED | NA
68 Participants

Nightmare Rescripting and Rehearsal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-01-21
Completion: 2025-12-09
Conditions
Nightmare Sleep
Interventions
BEHAVIORAL
No Results Yet
NCT04524767 | COMPLETED | NA
505 Participants

Depression Screening in Black Churches

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-08-01
Completion: 2025-04-12
Conditions
Depression
Interventions
BEHAVIORAL
No Results Yet
NCT04521699 | RECRUITING | NA
100 Participants

Examination of the Impact of CalmiGo's Stress Management Device on Vascular Heath and Cardiovascular Disease Risk.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2022-01-13
Completion: 2026-12-31
Conditions
Myocardial Infarction
Interventions
DEVICE
No Results Yet
NCT04512235 | ACTIVE_NOT_RECRUITING | PHASE3
284 Participants

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-11-03
Completion: 2025-04-08
Conditions
AL Amyloidosis
Interventions
DRUG OTHER
No Results Yet
NCT04496960 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
23 Participants

Safety of Tofacitinib, an Oral Janus Kinase Inhibitor, in Primary Sjogren's Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-05-18
Completion: 2025-01-14
Conditions
Sjogren's Syndrome
Interventions
DRUG OTHER
NCT04489433 | NO_LONGER_AVAILABLE

Compassionate Use Program to Access Trametinib and Dabrafenib for Patients With BRAF Mutation-positive Metastatic Melanoma

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-18
Conditions
Melanoma
Interventions
DRUG
No Results Yet
NCT04458402 | COMPLETED | NA
8 Participants

Adjuvant Hypofractionated Whole Pelvis Radiation Therapy in Endometrial Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-02-04
Completion: 2025-01-30
Conditions
Endometrial Cancer
Interventions
RADIATION
No Results Yet
NCT04446117 | ACTIVE_NOT_RECRUITING | PHASE3
575 Participants

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-10-19
Completion: 2024-04-19
Conditions
Metastatic Prostate Cancer Prostate Adenocarcinoma
Interventions
DRUG
NCT04438161 | ACTIVE_NOT_RECRUITING | NA
105 Participants

Study to Understand Risk and Resilience Opportunity for Newborns After Delivery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-01-26
Completion: 2026-03-01
Conditions
A. Longitudinal Cohort n=400 B. Lower Risk (n=45) and Higher Risk (n=105) Randomized 2:1 to PERCCS Intervention
Interventions
BEHAVIORAL
No Results Yet
NCT04432571 | ACTIVE_NOT_RECRUITING | NA
880 Participants

ADAPT for Adolescents Adolescents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-04-06
Completion: 2025-09-13
Conditions
HIV/AIDS
Interventions
BEHAVIORAL
No Results Yet
NCT04431700 | TERMINATED | NA
28 Participants

Study of Dietary Composition in Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-10-05
Completion: 2025-03-31
Conditions
Inflammatory Bowel Diseases Crohn Disease
Interventions
OTHER
No Results Yet
NCT04421768 | RECRUITING | NA
1125 Participants

Effects of Systematic Cervical Exam Training on Labor and Delivery Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-07-23
Completion: 2026-06-30
Conditions
Delivery Problem Cervix; Pregnancy Pregnancy Related
Interventions
BEHAVIORAL
No Results Yet
NCT04407754 | RECRUITING | NA
168 Participants

Myo-Inositol for Infertility in PCOS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2022-02-07
Completion: 2026-02-28
Conditions
Polycystic Ovary Syndrome
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04404283 | ACTIVE_NOT_RECRUITING | PHASE3
238 Participants

Brentuximab Vedotin Plus Lenalidomide and Rituximab for the Treatment of Relapsed/Refractory DLBCL

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-08-20
Completion: 2026-12-31
Conditions
Diffuse Large B-cell Lymphoma
Interventions
DRUG OTHER
No Results Yet
NCT04400357 | COMPLETED | NA
268 Participants

Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-09-28
Completion: 2024-11-28
Conditions
Pancreatic Adenocarcinoma Pancreatic Cysts Pancreatic Endocrine Tumors Chronic Pancreatitis Cholangiocarcinoma, Extrahepatic Ampullary Adenocarcinoma Duodenal Adenocarcinoma
Interventions
PROCEDURE
No Results Yet
NCT04396860 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
159 Participants

Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-09-01
Completion: 2023-01-13
Conditions
Gliosarcoma MGMT-Unmethylated Glioblastoma
Interventions
PROCEDURE BIOLOGICAL DEVICE OTHER RADIATION DRUG
NCT04395495 | RECRUITING
1000 Participants

RASopathy Biorepository

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2017-06-27
Completion: 2065-12-31
Conditions
RAS Mutation Neurofibromatosis 1 Noonan Syndrome Noonan Syndrome With Multiple Lentigines Noonan Neurofibromatosis Syndrome Cardiofaciocutaneous Syndrome Costello Syndrome Legius Syndrome Smith-Kingsmore Syndrome MTOR Gene Mutation GATOR-1 Gene Mutation SYNGAP1-Related Intellectual Disability DLG4 MAPK1 Gene Mutation
No Results Yet
NCT04382963 | COMPLETED | NA
120 Participants

Stroke Prevention in the Wisconsin Native American Population

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-04-14
Completion: 2025-10-01
Conditions
Stroke Atherosclerosis
Interventions
OTHER
No Results Yet
NCT04372875 | RECRUITING | NA
18500 Participants

Health Information Technology to Reduce Disparities in Adolescent Health Outcomes: A Pragmatic Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-03-08
Completion: 2026-12-31
Conditions
Sexually Transmitted Diseases
Interventions
BEHAVIORAL
No Results Yet
NCT04345913 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
24 Participants

Testing the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-03-01
Completion: 2024-03-28
Conditions
Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Triple-Negative Breast Carcinoma Unresectable Triple-Negative Breast Carcinoma
Interventions
DRUG PROCEDURE
NCT04332068 | COMPLETED | PHASE2
240 Participants

Ivermectin Safety in Small Children

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2023-11-18
Completion: 2025-04-04
Conditions
Scabies
Interventions
DRUG OTHER
No Results Yet
NCT04269590 | COMPLETED | NA
80 Participants

Triggering Motor Memory Consolidation in PD: Complex Practice of Fine Motor Tasks and Brain Activity During Learning

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2021-05-03
Completion: 2023-05-16
Conditions
Parkinson Disease
Interventions
BEHAVIORAL
No Results Yet
NCT04243499 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
292 Participants

First-in-Human Study of ICT01 in Patients With Advanced Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-03-05
Completion: 2026-10-31
Conditions
Solid Tumor, Adult Hematopoietic/Lymphoid Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT04228172 | ACTIVE_NOT_RECRUITING
32 Participants

Genotypic Influences on Network Progression in Parkinson's Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2020-02-24
Completion: 2025-12-31
Conditions
Parkinson's Disease
Interventions
GENETIC RADIATION OTHER
No Results Yet
NCT04217356 | RECRUITING
90 Participants

Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis

Study Type: OBSERVATIONAL
Last Updated: 2025-12-18
Start Date: 2020-08-05
Completion: 2026-12-31
Conditions
Myelofibrosis High-Risk Cancer Bone Marrow Cancer
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04210336 | COMPLETED | NA
200 Participants

Clinical Trial to Evaluate Papilocare® Gel Efficacy Into Repairment of Cervical Lesions Caused by HPV

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2018-08-07
Completion: 2022-11-30
Conditions
HPV Infection Lesion Cervix
Interventions
DEVICE
No Results Yet
NCT04209946 | COMPLETED | NA
180 Participants

Early Caffeine and LISA Compared to Caffeine and CPAP in Preterm Infants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-01-22
Completion: 2023-05-08
Conditions
Premature Lungs Respiratory Distress Syndrome Surfactant Deficiency Syndrome Neonatal
Interventions
PROCEDURE
No Results Yet
NCT04198766 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
296 Participants

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2019-12-10
Completion: 2026-10-30
Conditions
Solid Tumor Non-Small Cell Lung Cancer Head and Neck Cancer Melanoma Gastric Cancer Renal Cell Carcinoma Urothelial Carcinoma
Interventions
DRUG
No Results Yet
NCT04197934 | RECRUITING | PHASE1
55 Participants

WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2019-12-20
Completion: 2022-10-30
Conditions
Anaplastic Astrocytoma, IDH-Wildtype Glioblastoma, IDH-Wildtype Metastatic Lung Non-Small Cell Carcinoma Metastatic Malignant Neoplasm in the Central Nervous System Stage IV Lung Cancer AJCC v8
Interventions
PROCEDURE DRUG
No Results Yet
NCT04175431 | RECRUITING | PHASE2
100 Participants

Prostate Specific Membrane Antigen (PSMA) or (FACBC) PET/CT Site-Directed Therapy for Treatment of Prostate Cancer, Flu-BLAST-PC Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2020-09-30
Completion: 2028-07-01
Conditions
Prostate Adenocarcinoma
Interventions
PROCEDURE RADIATION DRUG
No Results Yet
NCT04162938 | RECRUITING | NA
308 Participants

Use of a Patient-Centered Electronic App to Increase ED Patient's Knowledge on HCV to Improve the HCV Care Continuum

Study Type: INTERVENTIONAL
Last Updated: 2025-12-18
Start Date: 2022-03-24
Completion: 2026-07-31
Conditions
Hepatitis C
Interventions
OTHER
No Results Yet
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