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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05781542 | COMPLETED | PHASE1
46 Participants

Clinical Trial to Evaluate the Safety and Immunogenicity of Synthetic DNAs Encoding NP-GT8 and IL-12, With or Without a TLR-agonist-Adjuvanted HIV Env Trimer 4571 Boost, in Adults Without HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-04-10
Completion: 2024-10-02
Conditions
HIV Infections
Interventions
BIOLOGICAL DRUG
Results Available
NCT05764213 | ACTIVE_NOT_RECRUITING | NA
10473 Participants

Improving Maternal Mental Health & SUD Screening and Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-04-03
Completion: 2027-07-31
Conditions
Mental Health Issue Substance Use Disorders Postpartum Depression Postpartum Anxiety
Interventions
BEHAVIORAL
No Results Yet
NCT05763537 | RECRUITING | NA
75 Participants

Understanding the Role of Doulas in Supporting People With PMADs

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-11-26
Completion: 2026-07-31
Conditions
Maternal Health Pregnancy Delivery, Obstetric Self Efficacy Social Support Mental Health Substance-Related Disorders Postpartum Depression Depression Mental Health Services
Interventions
BEHAVIORAL
No Results Yet
NCT05763420 | ENROLLING_BY_INVITATION | NA
156 Participants

Clinical Efficacy of AH Plus Bioceramic Sealer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-08-07
Completion: 2025-12-31
Conditions
Root Canal Infection Periapical Periodontitis Periapical Diseases
Interventions
DEVICE
No Results Yet
NCT05762107 | RECRUITING | PHASE2
186 Participants

A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-07-28
Completion: 2026-12-31
Conditions
Type 1 Diabetes Mellitus With Hypoglycemia
Interventions
DRUG
No Results Yet
NCT05755438 | COMPLETED | PHASE3
204 Participants

A Study to Evaluate the Safety and Efficacy of Ruxolitinib Cream in Participants With Prurigo Nodularis (PN)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-03-10
Completion: 2024-10-07
Conditions
Prurigo
Interventions
DRUG
Results Available
NCT05749146 | RECRUITING | NA
300 Participants

Palliative Care for Patients With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-06-08
Completion: 2027-03-01
Conditions
Dementia
Interventions
BEHAVIORAL
No Results Yet
NCT05746559 | ACTIVE_NOT_RECRUITING | PHASE3
736 Participants

ARTEMIS: Ravulizumab to Protect Patients With CKD From CSA-AKI and MAKE

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-04-06
Completion: 2026-05-18
Conditions
Chronic Kidney Disease CKD Cardiac Disease Cardiopulmonary Bypass
Interventions
DRUG
No Results Yet
NCT05740813 | COMPLETED | PHASE2/PHASE3
310 Participants

HEALEY ALS Platform Trial - Regimen F ABBV-CLS-7262

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-03-23
Completion: 2024-10-03
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
Results Available
NCT05738486 | ACTIVE_NOT_RECRUITING | PHASE3
1175 Participants

A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-02-28
Completion: 2024-05-16
Conditions
Alzheimer's Disease Dementia Brain Diseases Central Nervous System Diseases Nervous System Diseases Neurodegenerative Diseases Neurocognitive Disorders Mental Disorders
Interventions
DRUG
Results Available
NCT05732831 | RECRUITING | PHASE1/PHASE2
225 Participants

Safety and Tolerability of TNG462 in Patients With MTAP-deleted Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-05-26
Completion: 2026-05-31
Conditions
Locally Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT05722925 | ACTIVE_NOT_RECRUITING | PHASE4
50 Participants

Evaluating Fluciclovine PET in Patients With Biochemical Recurrence of Prostate Cancer and a Negative PSMA PET

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-10-04
Completion: 2026-12-01
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT05722210 | NOT_YET_RECRUITING
500 Participants

Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2031-06-30
Conditions
Hematopoietic Stem Cell Transplant
No Results Yet
NCT05713799 | NOT_YET_RECRUITING | PHASE2
60 Participants

Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2026-03-01
Conditions
Insulin Resistance Obesity
Interventions
DRUG
No Results Yet
NCT05704036 | RECRUITING | PHASE4
75 Participants

Estrogen Supplementation and Bone Health in Women With CF

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-05-02
Completion: 2027-01-31
Conditions
Cystic Fibrosis Hypoestrogenism
Interventions
DRUG
No Results Yet
NCT05692180 | RECRUITING | PHASE3
200 Participants

A Multicentre, Randomised, Double-blind, Parallel Group, Placebo-controlled, Time-to-first Asthma Exacerbation Phase III Efficacy and Safety Study of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-04-05
Completion: 2030-05-05
Conditions
Asthma
Interventions
DRUG
No Results Yet
NCT05690841 | RECRUITING | PHASE3
7530 Participants

FocaL Mass Drug Administration for Vivax Malaria Elimination

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2024-10-14
Completion: 2027-05-01
Conditions
Plasmodium Vivax Malaria Malaria
Interventions
DRUG
No Results Yet
NCT05687188 | RECRUITING
125 Participants

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2023-02-22
Completion: 2026-12-31
Conditions
Pancreatic Cancer
Interventions
OTHER
No Results Yet
NCT05675059 | ACTIVE_NOT_RECRUITING | NA
80 Participants

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Pancreatic Cancer Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-12-21
Completion: 2025-11-22
Conditions
Pancreatic Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT05670496 | RECRUITING
600 Participants

Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2023-03-08
Completion: 2026-08-01
Conditions
Hearing Loss Deafness
No Results Yet
NCT05664880 | RECRUITING | EARLY_PHASE1
24 Participants

A PiLot ClinicaL TrIal of ParicAlcitol for ChroNiC PancrEatitis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-06-01
Completion: 2026-06-01
Conditions
Chronic Pancreatitis
Interventions
DRUG
No Results Yet
NCT05663320 | RECRUITING | NA
20 Participants

A Study of a Virtual Education-Based Transition Intervention to Improve Transition Readiness in Adolescent and Young Adults With Congenital Adrenal Hyperplasia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2025-12-01
Conditions
Congenital Adrenal Hyperplasia
Interventions
OTHER
No Results Yet
NCT05657405 | RECRUITING
1250 Participants

Observational Study of Advanced Data Analytics in Genetic Conditions

Study Type: OBSERVATIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2032-12-31
Conditions
Genetic Conditions
No Results Yet
NCT05652504 | SUSPENDED | PHASE1
400 Participants

Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2025-11-30
Conditions
Malaria
Interventions
BIOLOGICAL OTHER DRUG
No Results Yet
NCT05652478 | RECRUITING | PHASE2
120 Participants

Early Metabolic Effects of Dolutegravir or Tenofovir Alefenamide in Healthy Volunteers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2028-01-31
Conditions
Healthy Volunteer Weight Gain Metabolic Effects Integrase Strand Transfer Inhibitors
Interventions
DRUG
No Results Yet
NCT05652465 | SUSPENDED | PHASE2
80 Participants

Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2026-01-30
Conditions
Major Depressive Disorder
Interventions
DEVICE
No Results Yet
NCT05652387 | COMPLETED | NA
216 Participants

Father Inclusive Prenatal Care Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2021-06-09
Completion: 2025-09-29
Conditions
Antenatal Care Pregnancy Related Parent-Child Relations Parenting Education Counseling
Interventions
BEHAVIORAL
No Results Yet
NCT05649969 | COMPLETED | NA
10 Participants

STRONG Program for Cancer Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-12-01
Completion: 2023-11-30
Conditions
Gastrointestinal Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT05643742 | RECRUITING | PHASE1/PHASE2
120 Participants

A Safety and Efficacy Study Evaluating CTX112 in Subjects With Relapsed or Refractory B-Cell Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-03-10
Completion: 2030-01-31
Conditions
B-cell Lymphoma Non-Hodgkin Lymphoma B-cell Malignancy Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) Follicular Lymphoma Mantle Cell Lymphoma Marginal Zone Lymphoma Large B-cell Lymphoma
Interventions
BIOLOGICAL
No Results Yet
NCT05642195 | SUSPENDED | PHASE1/PHASE2
30 Participants

Evaluation of a Cancer Lysate Vaccine and Montanide (Registered Trademark) ISA-51 VG With or Without the IL-15 Super-Agonist N-803 as Adjuvant Therapy for PD-L1 Negative Non-Small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2033-12-30
Conditions
Non-Small Cell Lung Cancer Non-Small Cell Lung Carcinoma Carcinoma, Non-Small-Cell Lung Carcinomas
Interventions
BIOLOGICAL DRUG DEVICE
No Results Yet
NCT05628961 | COMPLETED | PHASE1
42 Participants

Study of Single Oral Doses of HOPO 14-1 Evaluating Safety, Tolerability, Pharmacokinetics

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-03-15
Completion: 2025-08-04
Conditions
Toxicity;Chemical
Interventions
DRUG
No Results Yet
NCT05623202 | NOT_YET_RECRUITING | NA
60 Participants

Pilot Study of Capacity-oriented Intervention to Promote Food Security and Diet Quality Among Hispanics/Latinos

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2026-03-31
Completion: 2026-08-31
Conditions
Nutrition, Healthy Knowledge, Attitudes, Practice Self Efficacy
Interventions
BEHAVIORAL
No Results Yet
NCT05621291 | RECRUITING | NA
60 Participants

A Study to Evaluate Next-Generation Sequencing (NGS) Testing and Monitoring of B-cell Recovery to Guide Management Following Chimeric Antigen Receptor T-cell (CART) Induced Remission in Children and Young Adults With B Lineage Acute Lymphoblastic Leu...

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2025-11-19
Completion: 2026-12-31
Conditions
B-All Acute Lymphoblastic Leukemia
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05619302 | RECRUITING | PHASE3
65 Participants

Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-01-03
Completion: 2025-12-31
Conditions
Cardiac Amyloidosis
Interventions
DRUG
No Results Yet
NCT05583617 | RECRUITING | PHASE1/PHASE2
200 Participants

A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-11-14
Completion: 2028-07-31
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05582395 | COMPLETED | PHASE3
580 Participants

A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-12-14
Completion: 2025-03-06
Conditions
Cardiomyopathy, Hypertrophic
Interventions
DRUG OTHER
No Results Yet
NCT05571839 | ACTIVE_NOT_RECRUITING | PHASE1
41 Participants

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-01-03
Completion: 2025-12-06
Conditions
Cutaneous Melanoma Non-small Cell Lung Cancer Colorectal Neoplasms Pancreatic Neoplasms Mesothelioma
Interventions
DRUG
No Results Yet
NCT05559515 | COMPLETED | NA
214 Participants

Patient-centered Goal Setting in the National Diabetes Prevention Program

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2023-02-01
Completion: 2025-06-04
Conditions
PreDiabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05559164 | RECRUITING | PHASE2
60 Participants

Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-09-19
Completion: 2026-09-01
Conditions
Cardiac Toxicity Early-stage Breast Cancer
Interventions
DRUG
No Results Yet
NCT05544721 | ENROLLING_BY_INVITATION | PHASE4
50 Participants

A Study of Paravertebral Block in Thoracic Outlet Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-14
Start Date: 2022-10-05
Completion: 2027-08-31
Conditions
Thoracic Outlet Syndrome
Interventions
DRUG
No Results Yet
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