Clinical Trials

NCT04269902 | RECRUITING | PHASE3

247 Participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2021-03-02

Completion: 2028-10-01

Conditions

Chronic Lymphocytic Leukemia Small Lymphocytic Lymphoma

Interventions

PROCEDURE BIOLOGICAL OTHER DRUG

No Results Yet

NCT04267926 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

45 Participants

MitoQ for Fatigue in Multiple Sclerosis (MS)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-04-01

Completion: 2024-10-15

Conditions

Multiple Sclerosis Fatigue

Interventions

DRUG

Results Available

NCT04267848 | RECRUITING | PHASE3

1210 Participants

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-06-16

Completion: 2025-12-15

Conditions

Lung Non-Small Cell Carcinoma Lung Non-Small Cell Squamous Carcinoma Lung Non-Squamous Non-Small Cell Carcinoma Stage II Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8

Interventions

PROCEDURE DRUG OTHER BIOLOGICAL

No Results Yet

NCT04266249 | ACTIVE_NOT_RECRUITING | PHASE2

2175 Participants

CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-03-13

Completion: 2026-10-31

Conditions

Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Invasive Breast Carcinoma Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8

Interventions

DRUG PROCEDURE BIOLOGICAL RADIATION

No Results Yet

NCT04251806 | ACTIVE_NOT_RECRUITING

173 Participants

Sleep-disordered Breathing in Infants With Myelomeningocele

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2020-07-21

Completion: 2024-04-25

Conditions

Sleep-disordered Breathing Myelomeningocele

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT04248452 | RECRUITING | PHASE3

314 Participants

Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-05-26

Completion: 2028-03-31

Conditions

Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 Clinical Stage IV Gastric Cancer AJCC v8 Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8 Clinical Stage IVA Gastric Cancer AJCC v8 Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8 Clinical Stage IVB Gastric Cancer AJCC v8 Metastatic Esophageal Adenocarcinoma Metastatic Gastric Adenocarcinoma Oligometastatic Esophageal Adenocarcinoma Oligometastatic Gastric Adenocarcinoma Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8 Pathologic Stage IV Gastric Cancer AJCC v8 Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8 Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8

Interventions

DRUG RADIATION

No Results Yet

NCT04248257 | ACTIVE_NOT_RECRUITING | NA

560 Participants

Peer Support For Young Adult Women With High Breast Cancer Risk

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-07-15

Completion: 2026-04-30

Conditions

Breast Cancer Risk

Interventions

BEHAVIORAL

No Results Yet

NCT04239573 | ACTIVE_NOT_RECRUITING | NA

4606 Participants

Comparing Two Methods to Follow Patients With Pancreatic Cysts

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-06-16

Completion: 2037-06-03

Conditions

Pancreatic Carcinoma

Interventions

PROCEDURE OTHER

No Results Yet

NCT04233866 | ACTIVE_NOT_RECRUITING | PHASE2

176 Participants

Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-08-26

Completion: 2026-06-30

Conditions

Metastatic Pancreatic Adenocarcinoma Stage IV Pancreatic Cancer AJCC v8

Interventions

DRUG OTHER

No Results Yet

NCT04188509 | TERMINATED | PHASE3

162 Participants

Open-Label Extension of Voxelotor

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-11-18

Completion: 2024-11-01

Conditions

Sickle Cell Disease

Interventions

DRUG

Results Available

NCT04181827 | ACTIVE_NOT_RECRUITING | PHASE3

419 Participants

A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-06-12

Completion: 2024-05-01

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT04166318 | ACTIVE_NOT_RECRUITING | PHASE2

252 Participants

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-01-02

Completion: 2029-12-31

Conditions

Anal Basaloid Carcinoma Anal Canal Cloacogenic Carcinoma Anal Canal Squamous Cell Carcinoma Anal Margin Squamous Cell Carcinoma Stage I Anal Cancer AJCC v8 Stage IIA Anal Cancer AJCC v8

Interventions

PROCEDURE DRUG OTHER RADIATION

No Results Yet

NCT04142320 | RECRUITING | NA

54 Participants

Closed-loop Optimized rTMS for Depression

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2021-06-01

Completion: 2025-08-30

Conditions

Major Depressive Disorder

Interventions

DEVICE

No Results Yet

NCT04139499 | COMPLETED

18 Participants

Use of High-resolution Manometry to Detect Upper Airway Obstruction During Sleep

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-16

Completion: 2021-05-05

Conditions

Obstructive Sleep Apnea

Interventions

PROCEDURE

No Results Yet

NCT04116671 | ACTIVE_NOT_RECRUITING | NA

5 Participants

Stimulation Combined With Powered Motorized Orthoses for Walking After Stroke

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-04-01

Completion: 2026-11-01

Conditions

Stroke Hemiparesis

Interventions

DEVICE

No Results Yet

NCT04115631 | ACTIVE_NOT_RECRUITING | PHASE2

360 Participants

A Comparison of Three Chemotherapy Regimens for the Treatment of Patients With Newly Diagnosed Mantle Cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-12-13

Completion: 2026-12-31

Conditions

Liver Lymphoma Mantle Cell Lymphoma

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT04115254 | RECRUITING | NA

397 Participants

Stereotactic Magnetic Resonance Guided Radiation Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-22

Completion: 2028-06-30

Conditions

Pancreas Cancer Lung Cancer Renal Cancer Adrenal Metastases Prostate Cancer Liver Metastases Oligoprogressive Nodal Metastases Metachronous Nodal Metastases Synchronous Nodal Metastases Mesothelioma Spine Metastases Brain Metastases Borderline Resectable Pancreatic Carcinoma

Interventions

RADIATION

No Results Yet

NCT04108208 | ACTIVE_NOT_RECRUITING | PHASE4

75 Participants

A Study of Apalutamide in Chinese Participants With Non Metastatic Castration Resistant Prostate Cancer (NM-CRPC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-12-17

Completion: 2023-06-01

Conditions

Prostatic Neoplasms

Interventions

DRUG

Results Available

NCT04105868 | COMPLETED | NA

15 Participants

Adolescent Attention to Emotion Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-16

Completion: 2024-09-23

Conditions

Depression

Interventions

OTHER

Results Available

NCT04095663 | RECRUITING | NA

250 Participants

Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-10-01

Completion: 2027-02-01

Conditions

Diverticulitis

Interventions

PROCEDURE OTHER

No Results Yet

NCT04091048 | COMPLETED

1127 Participants

Optimize PRO Study

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-09-16

Completion: 2023-12-15

Conditions

Symptomatic Aortic Stenosis

Interventions

DEVICE

Results Available

NCT04064827 | TERMINATED | PHASE3

2 Participants

A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-09-16

Completion: 2025-05-16

Conditions

Chronic Kidney Disease (CKD) Secondary Hyperparathyroidism (SHPT)

Interventions

DRUG

No Results Yet

NCT04024436 | TERMINATED | PHASE2

64 Participants

A Study of TAS-120 in Patients With Metastatic Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-01-28

Completion: 2023-05-31

Conditions

Metastatic Breast Cancer FGFR 1 High Amplification FGFR2 Amplification

Interventions

DRUG

Results Available

NCT03978442 | COMPLETED | PHASE4

120 Participants

CPT-SMART for Treatment of PTSD and Cigarette Smoking

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-11-07

Completion: 2025-10-08

Conditions

Smoking Stress Disorders, Post-Traumatic

Interventions

BEHAVIORAL DRUG

No Results Yet

NCT03937635 | RECRUITING | PHASE3

288 Participants

Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-09-16

Completion: 2029-12-31

Conditions

Smoldering Plasma Cell Myeloma

Interventions

BIOLOGICAL DRUG OTHER

No Results Yet

NCT03935750 | ACTIVE_NOT_RECRUITING | NA

1236 Participants

STABILITY 2: Anterior Cruciate Ligament Reconstruction +/- Lateral Tenodesis With Patellar vs Quad Tendon

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-07-28

Completion: 2026-02-28

Conditions

Anterior Cruciate Ligament Injury Anterior Cruciate Ligament Reconstruction Joint Instability

Interventions

PROCEDURE

No Results Yet

NCT03901963 | ACTIVE_NOT_RECRUITING | PHASE3

200 Participants

A Study of Daratumumab Plus Lenalidomide Versus Lenalidomide Alone as Maintenance Treatment in Participants With Newly Diagnosed Multiple Myeloma Who Are Minimal Residual Disease Positive After Frontline Autologous Stem Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-04-26

Completion: 2024-04-04

Conditions

Multiple Myeloma

Interventions

DRUG

Results Available

NCT03899155 | RECRUITING | PHASE2

1500 Participants

Pan Tumor Rollover Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-08-09

Completion: 2029-08-25

Conditions

Cancer

Interventions

DRUG

No Results Yet

NCT03818763 | ACTIVE_NOT_RECRUITING | PHASE1

5 Participants

Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2020-04-29

Completion: 2026-03-31

Conditions

Hemophilia A

Interventions

BIOLOGICAL

No Results Yet

NCT03804255 | WITHDRAWN

0 Participants

Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Community Setting

Study Type: OBSERVATIONAL

Last Updated: 2025-11-13

Start Date: 2019-01-08

Completion: 2020-05-29

Conditions

Breast Carcinoma Colorectal Carcinoma Community Practice Lung Carcinoma Melanoma Solid Neoplasm

Interventions

OTHER

No Results Yet

NCT03797183 | RECRUITING

Study Type: INTERVENTIONAL

Last Updated: 2025-11-13

Start Date: 2019-04-29

Completion: 2029-01-31

Conditions

Secondary Hyperparathyroidism Chronic Kidney Disease

Interventions

DRUG

No Results Yet