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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06894511 | RECRUITING | PHASE2
420 Participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI Versus AAA617 in PSMA Positive First-line mCRPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-11
Completion: 2029-04-09
Conditions
Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions
DRUG
No Results Yet
NCT06892548 | RECRUITING | PHASE1/PHASE2
594 Participants

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-02
Completion: 2027-08-31
Conditions
Advanced Lung Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT06890884 | RECRUITING | PHASE2
594 Participants

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-11
Completion: 2027-12-13
Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06887972 | ACTIVE_NOT_RECRUITING | PHASE4
100 Participants

A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-21
Completion: 2025-10-24
Conditions
Acute Pain
Interventions
DRUG
No Results Yet
NCT06884449 | COMPLETED | NA
135 Participants

A Placebo-Controlled Study Evaluating the Effects of Arrabina P on Satiety in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-15
Completion: 2025-10-28
Conditions
Satiety Appetite Regulation Weight Control
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06882785 | RECRUITING | PHASE3
250 Participants

A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-10
Completion: 2028-09-23
Conditions
Schizophrenia
Interventions
DRUG OTHER
No Results Yet
NCT06881784 | RECRUITING | PHASE3
420 Participants

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-06
Completion: 2027-12-01
Conditions
NSCLC (Non-small Cell Lung Cancer) Non-Small Cell Lung Cancer NSCLC NSCLC (Non-small Cell Lung Carcinoma) NSCLC (Advanced Non-small Cell Lung Cancer)
Interventions
DRUG
No Results Yet
NCT06880744 | RECRUITING | PHASE3
530 Participants

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-17
Completion: 2028-09-30
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT06878365 | RECRUITING | PHASE1
18 Participants

A Study to Test How Well BI 3000202 is Tolerated by People With Type 1 Interferonopathies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-29
Completion: 2026-12-06
Conditions
Type 1 Interferonopathies
Interventions
DRUG
No Results Yet
NCT06872125 | RECRUITING | PHASE3
150 Participants

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-04
Completion: 2027-03-31
Conditions
Dravet Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT06869447 | NOT_YET_RECRUITING | NA
100 Participants

New York Better Breathing Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-15
Completion: 2028-03-15
Conditions
Localized Lung Carcinoma Stage I Lung Cancer AJCC v8 Stage II Lung Cancer AJCC v8 Stage III Lung Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT06866405 | RECRUITING | PHASE3
550 Participants

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-16
Completion: 2028-02-24
Conditions
RSV Infection
Interventions
BIOLOGICAL
No Results Yet
NCT06864169 | RECRUITING | PHASE2
160 Participants

A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-01
Completion: 2026-07-06
Conditions
Gastrointestinal Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT06863272 | RECRUITING | PHASE1/PHASE2
360 Participants

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-03
Completion: 2030-02-18
Conditions
Castration-Resistant Prostatic Cancer Metastasis
Interventions
DRUG
No Results Yet
NCT06861790 | RECRUITING | NA
120 Participants

WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-10
Completion: 2027-12-31
Conditions
Diabetes Weight Loss
Interventions
BEHAVIORAL PROCEDURE
No Results Yet
NCT06860386 | RECRUITING | PHASE2
75 Participants

Study of Adaptive Immunotherapy With VEGFR-TKI in Patients With Advanced RCC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-25
Completion: 2028-02-29
Conditions
Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06855277 | RECRUITING | PHASE3
605 Participants

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-01
Completion: 2028-02-29
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06846671 | RECRUITING | PHASE3
250 Participants

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-10
Completion: 2028-05-15
Conditions
CLL Chronic Lymphocytic Leukemia
Interventions
DRUG
No Results Yet
NCT06846320 | RECRUITING | PHASE2
315 Participants

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-29
Completion: 2026-11-30
Conditions
Generalized Anxiety Disorder (GAD)
Interventions
DRUG
No Results Yet
NCT06845202 | RECRUITING | PHASE1/PHASE2
144 Participants

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-03
Completion: 2027-08-31
Conditions
Obese or Overweight Healthy Volunteers Type 2 Diabetes Mellitus (T2DM)
Interventions
DRUG
No Results Yet
NCT06843967 | RECRUITING | PHASE1/PHASE2
54 Participants

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-19
Completion: 2028-08-19
Conditions
Well Differentiated Liposarcoma Dedifferentiated Liposarcoma Liposarcoma Myxoid Liposarcoma Round Cell Liposarcoma Myxoid Pleomorphic Liposarcoma Pleomorphic Liposarcoma Unresectable Liposarcoma Unresectable Dedifferentiated Liposarcoma
Interventions
DRUG
No Results Yet
NCT06836414 | NOT_YET_RECRUITING | NA
1200 Participants

Lung Cancer Screening CT for Firefighters

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-03-31
Completion: 2035-12-31
Conditions
Smoke Inhalation Exposure, Inhalation Exposure to Pollution Exposure Occupational Lung Diseases Lung Cancer Lung Diseases, Interstitial Occupational Exposure Occupational Lung Disease Interstitial Lung Disease
Interventions
PROCEDURE OTHER
No Results Yet
NCT06833073 | RECRUITING | PHASE2
308 Participants

A Clinical Study of Intismeran Autogene (V940) and BCG in People With Bladder Cancer (V940-011/INTerpath-011)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-11
Completion: 2031-09-03
Conditions
Urinary Bladder Neoplasms Non-Muscle Invasive Bladder Neoplasms Carcinoma in Situ
Interventions
BIOLOGICAL
No Results Yet
NCT06831526 | RECRUITING | EARLY_PHASE1
12 Participants

Neoadjuvant Chemoradiotherapy With or Without Concurrent Azeliragon in Patients With Newly Diagnosed Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-06
Completion: 2029-02-28
Conditions
Glioblastoma
Interventions
DRUG RADIATION PROCEDURE
No Results Yet
NCT06830629 | RECRUITING | PHASE2
56 Participants

A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-05
Completion: 2026-09-30
Conditions
Proteinuric Kidney Disease
Interventions
DRUG
No Results Yet
NCT06830044 | RECRUITING | PHASE3
500 Participants

Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-03
Completion: 2028-03-31
Conditions
Major Depressive Disorder (MDD)
Interventions
DRUG
No Results Yet
NCT06825871 | RECRUITING | NA
26 Participants

Automated Inhaler Monitoring for Asthma Medication Usage

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-31
Completion: 2026-03-31
Conditions
Asthma
Interventions
DEVICE
No Results Yet
NCT06822738 | RECRUITING | PHASE3
130 Participants

A Study to Assess Adverse Events and Effectiveness of Gel Stent (XEN63) Implantation Using Ab Interno and Ab Externo Approaches in Adult Participants With Glaucoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-11
Completion: 2028-11-30
Conditions
Primary Open Angle Glaucoma
Interventions
DEVICE
No Results Yet
NCT06820957 | RECRUITING | PHASE2/PHASE3
437 Participants

Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-07-17
Completion: 2032-07-15
Conditions
CIC-Rearranged Sarcoma Metastatic Ewing Sarcoma Metastatic High Grade Sarcoma Metastatic Undifferentiated Round Cell Sarcoma Metastatic Undifferentiated Sarcoma, Not Otherwise Specified Round Cell Sarcoma With EWSR1-non-ETS Fusion Sarcoma With BCOR Genetic Alterations
Interventions
PROCEDURE DRUG OTHER RADIATION
No Results Yet
NCT06819891 | RECRUITING | PHASE3
425 Participants

A Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-12
Completion: 2028-12-31
Conditions
Moderately to Severely Active Crohns Disease
Interventions
DRUG
No Results Yet
NCT06819878 | RECRUITING | PHASE3
600 Participants

A Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-17
Completion: 2028-12-31
Conditions
Moderately to Severely Active Crohns Disease
Interventions
DRUG
No Results Yet
NCT06812494 | RECRUITING | PHASE2
200 Participants

A Study of VRC07-523LS, PGT121.414.LS, and PGDM1400LS Broadly Neutralizing Monoclonal Antibodies Given Intravenously in Adult Participants Without HIV

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-07
Completion: 2027-01-15
Conditions
HIV
Interventions
BIOLOGICAL
No Results Yet
NCT06811038 | NOT_YET_RECRUITING | PHASE3
854 Participants

iCanQuit Smoking Cessation Among Hispanic Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-01-01
Completion: 2029-07-01
Conditions
Cigarette Smoking-Related Carcinoma
Interventions
DEVICE DRUG OTHER
No Results Yet
NCT06808477 | RECRUITING | PHASE1
198 Participants

A Study of BBT001 in Healthy Volunteers (HVs) and in Adult Patients With Atopic Dermatitis (AD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-27
Completion: 2026-08-21
Conditions
Atopic Dermatitis
Interventions
DRUG
No Results Yet
NCT06806592 | RECRUITING | PHASE3
400 Participants

A Study to Test Whether Nerandomilast Helps People With Lungfibrosis Related to Rheumatic Diseases

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-13
Completion: 2027-07-17
Conditions
Interstitial Lung Diseases Systemic Autoimmune Rheumatic Diseases Associated Interstitial Lung Diseases
Interventions
DRUG
No Results Yet
NCT06805630 | RECRUITING | NA
50 Participants

Urine Methylation Markers in UTUC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-07
Completion: 2026-06-30
Conditions
Upper Tract Urothelial Cancer
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06804603 | COMPLETED | PHASE2
124 Participants

A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-25
Completion: 2025-10-06
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT06784752 | RECRUITING | PHASE3
240 Participants

Study to Evaluate the Efficacy and Safety of [177Lu]Lu-DOTA-TATE in Patients With Grade 1 and Grade 2 Advanced GEP-NET

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-30
Completion: 2030-09-27
Conditions
Somatostatin Receptor Positive (SSTR+) Gastroenteropancreatic Neuroendocrine Tumor (GEP-NET)
Interventions
RADIATION DRUG
No Results Yet
NCT06782490 | RECRUITING | PHASE2
200 Participants

A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-05
Completion: 2026-11-18
Conditions
Multiple Sclerosis Spasticity
Interventions
DRUG
No Results Yet
NCT06780670 | RECRUITING | PHASE2/PHASE3
432 Participants

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-27
Completion: 2028-06-27
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
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