A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia

NCT ID: NCT06882785

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

250 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-10

Study Completion Date

2029-08-23

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of KarXT in acutely psychotic Japanese adult participants with schizophrenia

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Administration of KarXT

Group Type ACTIVE_COMPARATOR

KarXT

Intervention Type DRUG

Specified dose on specified days

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Specified dose on specified days

Interventions

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KarXT

Specified dose on specified days

Intervention Type DRUG

Placebo

Specified dose on specified days

Intervention Type OTHER

Other Intervention Names

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BMS-986510

Eligibility Criteria

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Inclusion Criteria

* Participants must have a primary diagnosis of schizophrenia established by a comprehensive psychiatric evaluation based on the Diagnostic and Statistical Manual of Mental Disorders⎯Fifth Edition (DSM-5) criteria and confirmed by Mini International Neuropsychiatric Interview (MINI).
* Participants must have a PANSS total score between 80 and 120, inclusive.
* Participants must have a CGI-S score of ≥ 4.

Exclusion Criteria

* Participants must not have any primary DSM-5 disorder other than schizophrenia within 12 months before screening.
* Participants must not be newly diagnosed or experiencing their first treated episode of schizophrenia.
* Participants must not have any history or presence of clinically significant medical conditions.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Hotei Hospital

Kōnan, Aichi-ken, Japan

Site Status RECRUITING

Local Institution - 0056

Nagoya, Aichi-ken, Japan

Site Status NOT_YET_RECRUITING

Okehazama Hospital

Toyoake, Aichi-ken, Japan

Site Status RECRUITING

Fujita Health University

Toyoake, Aichi-ken, Japan

Site Status RECRUITING

National Kohnodai Medical Center.

Ichikawa, Chiba, Japan

Site Status RECRUITING

Local Institution - 0015

MIdori-ku, Chiba-shi, Chiba, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0032

Iizuka, Fukuoka, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0037

Kitakyushu, Fukuoka, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0016

Omuta, Fukuoka, Japan

Site Status NOT_YET_RECRUITING

Takeda General Hospital - Aizuwakamatsu

Aizu-Wakamatsu, Fukushima, Japan

Site Status RECRUITING

Local Institution - 0044

Toki, Gifu, Japan

Site Status NOT_YET_RECRUITING

Kure Medical Center

Kure, Hiroshima, Japan

Site Status RECRUITING

Goryokai Medical Corporation - Goryokai Hospital

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Hokkaido University Hospital

Sapporo, Hokkaido, Japan

Site Status RECRUITING

Local Institution - 0025

Hadano-shi, Kanagawa, Japan

Site Status NOT_YET_RECRUITING

Fujimidai Hospital

Hiratsuka, Kanagawa, Japan

Site Status RECRUITING

Local Institution - 0052

Sagamihara, Kanagawa, Japan

Site Status NOT_YET_RECRUITING

Tsurumi Nishii Hospital

Yokohama, Kanagawa, Japan

Site Status RECRUITING

Local Institution - 0028

Yokohama, Kanagawa, Japan

Site Status NOT_YET_RECRUITING

Hino Hospital - Yokohama

Yokohama, Kanagawa, Japan

Site Status RECRUITING

Yuge Hospital

Kumamoto, Kumamoto, Japan

Site Status RECRUITING

Local Institution - 0019

Yatsushiro, Kumamoto, Japan

Site Status WITHDRAWN

National Hospital Organization Maizuru Medical Center

Maizuru, Kyoto, Japan

Site Status RECRUITING

Miyakonojo Shinsei Hospital

Miyakonojō, Miyazaki, Japan

Site Status RECRUITING

Local Institution - 0014

Komoro, Nagano, Japan

Site Status WITHDRAWN

Local Institution - 0050

Matsumoto, Nagano, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0051

Ginowan, Okinawa, Japan

Site Status NOT_YET_RECRUITING

Osaka Psychiatric Medical Center

Hirakata, Osaka, Japan

Site Status RECRUITING

Kansai Medical University Medical Center

Moriguchi, Osaka, Japan

Site Status RECRUITING

Nagaokai Medical Corporation - Neyagawa Sanatorium

Neyagawa, Osaka, Japan

Site Status RECRUITING

Shin-Abuyama Hospital

Takatsuki, Osaka, Japan

Site Status RECRUITING

Osaka Medical and Pharmaceutical University Hospital

Takatsuki, Osaka, Japan

Site Status RECRUITING

Rainbow and Sea Hospital

Karatsu-shi, Saga-ken, Japan

Site Status RECRUITING

Inuo Hospital

Tosu, Saga-ken, Japan

Site Status RECRUITING

Saitama Konan Hospital

Kumagaya, Saitama, Japan

Site Status RECRUITING

Dokkyo Medical University Hospital

Shimotsuga, Tochigi, Japan

Site Status RECRUITING

Local Institution - 0043

Utsunomiya, Tochigi, Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0012

Hachiōji, Tokyo, Japan

Site Status WITHDRAWN

National Center of Neurology and Psychiatry

Kodaira, Tokyo, Japan

Site Status RECRUITING

Asuka Hospital

Machida, Tokyo, Japan

Site Status RECRUITING

Local Institution - 0053

Ōta-ku, Tokyo, Japan

Site Status NOT_YET_RECRUITING

Tokyo Metropolitan Matsuzawa Hospital

Setagaya City, Tokyo, Japan

Site Status RECRUITING

Narimasu Kosei Hospital

tabashi City, Tokyo, Japan

Site Status RECRUITING

Yamaguchi University Hospital

Ube, Yamaguchi, Japan

Site Status RECRUITING

Kuramitsu Hospital

Fukuoka, , Japan

Site Status RECRUITING

Local Institution - 0048

Kyoto, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0029

Miyazaki, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0055

Okayama, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0018

Okinawa, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0031

Osaka, , Japan

Site Status NOT_YET_RECRUITING

Saitama Neuropsychitric Institute

Saitama, , Japan

Site Status RECRUITING

Local Institution - 0039

Tokushima, , Japan

Site Status NOT_YET_RECRUITING

Local Institution - 0033

Tottori, , Japan

Site Status WITHDRAWN

Wakayama Medical University Hospital

Wakayama, , Japan

Site Status RECRUITING

Yamagata Sakuracho Hospital

Yamagata, , Japan

Site Status RECRUITING

Countries

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Japan

Central Contacts

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BMS Study Connect www.BMSStudyConnect.com

Role: CONTACT

Phone: 8559073286

Email: [email protected]

First line of the email MUST contain the NCT# and Site#

Role: CONTACT

Facility Contacts

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Takakura Masashi, Site 0034

Role: primary

Site 0056

Role: primary

kiyoshi Fujita, Site 0001

Role: primary

Taro Kishi, Site 0003

Role: primary

Toshihiko Ito, Site 0009

Role: primary

Site 0015

Role: primary

Site 0032

Role: primary

Site 0037

Role: primary

Site 0016

Role: primary

Koichi Osonoe, Site 0042

Role: primary

Site 0044

Role: primary

Wataru Omori, Site 0007

Role: primary

Kimihiro Nakajima, Site 0004

Role: primary

Naoki Hashimoto, Site 0049

Role: primary

Site 0025

Role: primary

Takafumi Yahoko, Site 0040

Role: primary

Site 0052

Role: primary

Herbert Nishii, Site 0023

Role: primary

Site 0028

Role: primary

Atsuomi Baba, Site 0035

Role: primary

Masahiro Shono, Site 0011

Role: primary

Sumihiro Yamano, Site 0046

Role: primary

Masahiko Kawano, Site 0017

Role: primary

Site 0050

Role: primary

Site 0051

Role: primary

Taro Matsuda, Site 0022

Role: primary

SHUNICHIRO IKEDA, Site 0026

Role: primary

Naohiko Matsumoto, Site 0021

Role: primary

Hiroki Kikuyama, Site 0005

Role: primary

Tetsufumi Kanazawa, Site 0024

Role: primary

Taro Shindo, Site 0010

Role: primary

Akifumi Inuo, Site 0038

Role: primary

Narifumi Yokoyama, Site 0020

Role: primary

Norio Furukori, Site 0047

Role: primary

Site 0043

Role: primary

Kyoji Okita, Site 0002

Role: primary

yoshie tamura, Site 0027

Role: primary

Site 0053

Role: primary

Keiko Genda, Site 0045

Role: primary

Yuya Tenjin, Site 0013

Role: primary

Fumihiro Higuchi, Site 0036

Role: primary

Noriko Tamaru, Site 0008

Role: primary

Site 0048

Role: primary

Site 0029

Role: primary

Site 0055

Role: primary

Site 0018

Role: primary

Site 0031

Role: primary

Hakuei Yamashita, Site 0041

Role: primary

Site 0039

Role: primary

Sohei Kimoto, Site 0006

Role: primary

Nobuhiro Yokokawa, Site 0030

Role: primary

Related Links

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Other Identifiers

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CN012-0019

Identifier Type: -

Identifier Source: org_study_id