Safety and Efficacy of Study Drug Versus Placebo for Negative Symptoms of Schizophrenia

NCT ID: NCT00063297

Last Updated: 2009-08-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

180 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-05-31

Study Completion Date

2003-10-31

Brief Summary

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This study is to determine the efficacy (how well the drug works), safety, and side effects of the study medication compared to placebo in the treatment of the negative symptoms of schizophrenia in adults.

Detailed Description

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Conditions

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Schizophrenia

Keywords

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schizophrenia with negative symptoms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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R209130

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adults aged 18-60
* Current diagnosis of schizophrenia
* Significant negative symptoms with few positive symptoms (e.g. hallucinations, delusions) and no evidence of major depression.
* Female subjects of childbearing potential must test negative for pregnancy at the time of enrollment.
* Subjects must be able to provide consent
* Must be healthy based on medical exam, laboratory tests and electrocardiogram

Exclusion:

* Female subjects who are either pregnant or nursing.
* Acute or unstable medical conditions
* Diseases of the central nervous system
* Subjects who are judged clinically to be at serious risk for suicide or violence
* Subjects with delusional disorder, psychotic disorder NOS, schizophreniform, schizoaffective disorder, bipolar disorder, attention deficit/hyperactivity disorder, major depressive disorder,alcohol or drug dependence
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

INDUSTRY

Sponsor Role lead

Locations

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Birmingham Psychiatry Pharmaceutical Studies, Inc.

Birmingham, Alabama, United States

Site Status

IPR

Cerritos, California, United States

Site Status

Synergy Clinical Research

Chula Vista, California, United States

Site Status

Optimum Health Services

La Mesa, California, United States

Site Status

Sierra Vista Hospital

Sacramento, California, United States

Site Status

Clinical Innovations

Santa Ana, California, United States

Site Status

Research Strategies

Torrance, California, United States

Site Status

University of Colorado

Denver, Colorado, United States

Site Status

Psychiatric Institute of Washington

Washington D.C., District of Columbia, United States

Site Status

Berma Research Group

Hialeah, Florida, United States

Site Status

Segal Institute for Clinical Research

North Miami, Florida, United States

Site Status

Quantum Laboratories

Pompano Beach, Florida, United States

Site Status

Med Psych Specialists, LLC

Atlanta, Georgia, United States

Site Status

Alexian Brothers Behavioral Health Hospital

Hoffman Estates, Illinois, United States

Site Status

Midwest Center for Neurobehavioral Medicine

Oakbrook Terrace, Illinois, United States

Site Status

Shreveport, Louisiana, United States

Site Status

University of Mississippi Medical Center-Dept. of Psychiatry

Jackson, Mississippi, United States

Site Status

CNS Research Institute

Clementon, New Jersey, United States

Site Status

Neurobehavioral Research

Lawrence, New York, United States

Site Status

Global Research & Consulting

Olean, New York, United States

Site Status

Bayley Seton Campus-Psychiatric Research Division

Staten Island, New York, United States

Site Status

Behavioral Medical Research of Staten Island, P.C.

Staten Island, New York, United States

Site Status

NorthCoast Clinical Trials

Beachwood, Ohio, United States

Site Status

IPS Research

Oklahoma City, Oklahoma, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Community Clinical Research

Austin, Texas, United States

Site Status

MedLabs Research of Houston

Houston, Texas, United States

Site Status

University Hills Clinical Research

Irving, Texas, United States

Site Status

Milwaukee VA Medical Center

Milwaukee, Wisconsin, United States

Site Status

Countries

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United States

Other Identifiers

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CR004342

Identifier Type: -

Identifier Source: org_study_id