NBI-1117568-SCZ3029: Evaluation of NBI-1117568 in Inpatient Adults With Schizophrenia

NCT ID: NCT06963034

Last Updated: 2025-12-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE3

Total Enrollment

284 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-08

Study Completion Date

2027-10-31

Brief Summary

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The primary objective for this study is to evaluate the efficacy of NBI-1117568 compared with placebo on improving behavioral and psychological symptoms of schizophrenia in adults.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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NBI-1117568

Participants will receive NBI-1117568 once daily (QD) orally from Day 1 to Day 35 for a total of 5 weeks.

Group Type EXPERIMENTAL

NBI-1117568

Intervention Type DRUG

NBI-1117568 will be administered per schedule specified in the arm description.

Placebo

Participants will receive matching placebo QD orally from Day 1 to Day 35 for a total of 5 weeks.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Placebo will be administered per schedule specified in the arm description.

Interventions

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NBI-1117568

NBI-1117568 will be administered per schedule specified in the arm description.

Intervention Type DRUG

Placebo

Placebo will be administered per schedule specified in the arm description.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participant has a primary diagnosis of schizophrenia
* Participant is experiencing an acute exacerbation or relapse of symptoms and currently warrants hospitalization.
* Participants taking prohibited medications, including antipsychotics, must discontinue before study participation
* Participant is willing and able to remain in an inpatient setting for the study duration, follow instructions, and comply with the protocol requirements

Exclusion Criteria

* Participant has known hypersensitivity to any component of the formulation of NBI-1117568.
* Participant has an unstable or poorly controlled medical condition or chronic disease
* Participant is considered by the investigator to be at imminent risk of suicide or injury to self or others
* Participant has a diagnosis of moderate or severe substance use disorder (with the exception of nicotine or caffeine dependence) within 6 months prior to screening
* Participant has a positive alcohol test or drug screen for disallowed substances
* Participants have a history of poor or suspected poor compliance in clinical research studies and/or in the investigator's opinion, the participant is not capable of adhering to the protocol requirements.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Neurocrine Biosciences

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Development Lead

Role: STUDY_DIRECTOR

Neurocrine Biosciences

Locations

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Neurocrine Clinical Site

Little Rock, Arkansas, United States

Site Status RECRUITING

Neurocrine Clinical Site

Anaheim, California, United States

Site Status RECRUITING

Neurocrine Clinical Site

Pico Rivera, California, United States

Site Status RECRUITING

Neurocrine Clinical Site

San Diego, California, United States

Site Status RECRUITING

Neurocrine Clinical Site

Sherman Oaks, California, United States

Site Status RECRUITING

Neurocrine Clinical Site

Torrance, California, United States

Site Status RECRUITING

Neurocrine Clinical Site

Hollywood, Florida, United States

Site Status RECRUITING

Neurocrine Clinical Site

Miami Lakes, Florida, United States

Site Status RECRUITING

Neurocrine Clinical Site

Atlanta, Georgia, United States

Site Status RECRUITING

Neurocrine Clinical Site

Decatur, Georgia, United States

Site Status RECRUITING

Neurocrine Clinical Site

Peachtree Corners, Georgia, United States

Site Status RECRUITING

Neurocrine Clinical Site

Chicago, Illinois, United States

Site Status RECRUITING

Neurocrine Clinical Site

Gaithersburg, Maryland, United States

Site Status RECRUITING

Neurocrine Clinical Site

Watertown, Massachusetts, United States

Site Status RECRUITING

Neurocrine Clinical Site

Marlton, New Jersey, United States

Site Status RECRUITING

Neurocrine Clinical Site

Staten Island, New York, United States

Site Status RECRUITING

Neurocrine Clinical Site

The Bronx, New York, United States

Site Status RECRUITING

Neurocrine Clinical Site

Austin, Texas, United States

Site Status RECRUITING

Neurocrine Clinical Site

DeSoto, Texas, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Neurocrine Medical Information Call Center

Role: CONTACT

877-641-3461

Other Identifiers

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NBI-1117568-SCZ3029

Identifier Type: -

Identifier Source: org_study_id

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