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Lung Cancer Screening CT for Firefighters

NCT ID: NCT06836414

Last Updated: 2025-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

1200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2026-03-31

Study Completion Date

2035-12-31

Brief Summary

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Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as firefighting. This study aims to provide chest computed tomography (CT) scans to firefighters to determine the prevalence of lung cancer, other cancers detectable on CT chest, and lung diseases associated with increased cancer risk.

Detailed Description

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This is a single-group prospective interventional study and a community-based participatory project led by University of California, San Francisco and in close collaboration with the firefighter community in California.

PRIMARY OBJECTIVE:

I. Determine the prevalence of lung cancer, other cancers and cancer risk factors detectable on chest Computerized Tomography (CT) (Aim 1).

II. Identify imaging and non-imaging predictors of lung cancer and other cancers detectable on chest CT.

SECONDARY OBJECTIVE:

I. Determine the prevalence of incidental findings on chest CT (Aim 1).

II. Determine the risk factors for cancer development in firefighters (Aim 2).

EXPLORATORY OBJECTIVES:

I. Long term follow-up to determine the incidence of lung cancer and other cancers among firefighters.

II. Develop a firefighter cancer imaging registry.

OUTLINE:

Participants will be administered a single, low dose chest CT to included participants and collect comprehensive demographic, clinical, and occupational data. Participants will be followed up at 1-2 months, for at least 1 year and up to 10 years to collect any follow-up imaging and biopsy results, if applicable.

Conditions

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Smoke Inhalation Exposure, Inhalation Exposure to Pollution Exposure Occupational Lung Diseases Lung Cancer Lung Diseases, Interstitial Occupational Exposure Occupational Lung Disease Interstitial Lung Disease

Keywords

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Population research Cancer Screening

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Firefighters (Lung Screening CT)

Participants will receive a single, low-dose, chest CT without contrast as indicated for lung cancer screening. Participants will be followed up for at least 1 year following the scan and have ongoing medical record reviews.

Group Type OTHER

Low-dose Computerized tomography (CT) of Chest

Intervention Type PROCEDURE

Undergo CT for lung cancer screening

Questionnaires

Intervention Type OTHER

Participants will complete questionnaires on or before the day of the scan.

Medical History

Intervention Type OTHER

Medical history will be obtained in person and via medical record review

Firefighters with Previously Diagnosed Malignancy

Participants with a history of cancer will have a medical record review as part of a case-control cohort.

Group Type OTHER

Medical History

Intervention Type OTHER

Medical history will be obtained in person and via medical record review

Interventions

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Low-dose Computerized tomography (CT) of Chest

Undergo CT for lung cancer screening

Intervention Type PROCEDURE

Questionnaires

Participants will complete questionnaires on or before the day of the scan.

Intervention Type OTHER

Medical History

Medical history will be obtained in person and via medical record review

Intervention Type OTHER

Other Intervention Names

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Chest CT Chest CT Scan Low-dose Chest CT Medical Record Review Medical Chart Review

Eligibility Criteria

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Inclusion Criteria

1. Age 35 years or greater. If the participant is above the age of 80, participants must be otherwise healthy and well-fit to undergo treatment if lung cancer were to be discovered.
2. Never smoker or quit more than 15 years ago.
3. Able to understand study procedures and to comply with them for the entire length of the study.
4. Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it.
5. Length in profession for 10 or more years. This includes both volunteer firefighting and professional firefighting, self-attested as verifiable by professional records.

Additional cases for Aim 2:

1. Age 18+, may include deceased firefighters.
2. A previous or current history of confirmed thoracic malignancy (except localized skin cancer, cancer in situ, or other localized cancers)

Exclusion Criteria

* Aim 1:

1. Contraindication to any study-related procedure or assessment.
2. Personal history of malignancy within 5 years (except localized skin cancer, cancer in situ, or localized cancers that are definitively treated and are unlikely to recur) or lung cancer at any time.
3. Participants will be assessed for active pregnancy per standard procedure for clinical lung cancer screening CT at University of California, San Francisco which includes asking the participants directly along with documentation of whether the negative pregnancy was self-reported or confirmed with a urine pregnancy test.
4. Prior CT chest within 1 year.
5. Symptoms highly suggestive of lung cancer, including unexplained weight loss of over 30 pounds (lbs) within the past 12 months or unexplained hemoptysis.
* Aim 2:
Minimum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Hayward Firefighters Local 1909 of the International Association of Firefighters

UNKNOWN

Sponsor Role collaborator

University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jae Ho Sohn, MD, MS

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California, San Francisco

San Francisco, California, United States

Site Status

Countries

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United States

Central Contacts

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Jae Ho Sohn, MD, MS

Role: CONTACT

Phone: 877-827-3222

Email: [email protected]

Ali Nowroozi, MD

Role: CONTACT

Phone: 877-827-3222

Email: [email protected]

Facility Contacts

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Jae Ho Sohn, MD, MS

Role: primary

Role: backup

Other Identifiers

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NCI-2025-00336

Identifier Type: REGISTRY

Identifier Source: secondary_id

24053

Identifier Type: -

Identifier Source: org_study_id