Lung Cancer Risk and Early Detection in Firefighters

NCT ID: NCT04614129

Last Updated: 2025-11-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

734 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-03-02

Study Completion Date

2025-11-01

Brief Summary

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This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Detailed Description

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Conditions

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Lung Cancer Lung Diseases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Low-Dose CT

Low Dose CT Scan of the Chest

Group Type EXPERIMENTAL

Low Dose CT

Intervention Type DIAGNOSTIC_TEST

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Interventions

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Low Dose CT

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Intervention Type DIAGNOSTIC_TEST

Other Intervention Names

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LDCT

Eligibility Criteria

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Inclusion Criteria

* 40-80 years of age or with 10 years of firefighting experience
* Current or retired firefighters
* No personal history of lung cancer
* Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study

Exclusion Criteria

* Any active cancer (undergoing treatment or diagnosed within the past 5 years)
Minimum Eligible Age

40 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Massachusetts General Hospital

OTHER

Sponsor Role lead

Responsible Party

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Erica T. Warner, ScD MPH

Associate Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Erica T Warner, ScD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Lecia V Sequist, MD

Role: PRINCIPAL_INVESTIGATOR

Massachusetts General Hospital

Locations

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Massachusetts General Hospital

Boston, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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2020P002693

Identifier Type: -

Identifier Source: org_study_id

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