Clinical Trials

NCT06126276 | RECRUITING | PHASE2

70 Participants

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-05-07

Completion: 2027-02-20

Conditions

Malignant Female Reproductive System Neoplasm Malignant Solid Neoplasm Recurrent Malignant Female Reproductive System Neoplasm Recurrent Malignant Solid Neoplasm

Interventions

PROCEDURE DRUG

No Results Yet

NCT06123195 | RECRUITING | NA

40 Participants

Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-01

Completion: 2025-11-17

Conditions

Chronic Kidney Disease Constipation

Interventions

OTHER

No Results Yet

NCT06122935 | COMPLETED | NA

6735 Participants

Evaluation of the Aurora Xi New Nomogram Software 2.0

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-27

Completion: 2024-04-19

Conditions

Apheresis Related Hypotension

Interventions

DEVICE

Results Available

NCT06121297 | RECRUITING | PHASE1/PHASE2

12 Participants

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-16

Completion: 2027-12-31

Conditions

Systemic Lupus Erythematosus Lupus Nephritis

Interventions

BIOLOGICAL

No Results Yet

NCT06117891 | RECRUITING

300 Participants

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-27

Completion: 2026-11-27

Conditions

Unresectable Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT06112418 | RECRUITING | NA

7500 Participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-03-06

Completion: 2029-03-05

Conditions

Diabetes Mellitus, Type 2 PreDiabetes Metabolic Syndrome

Interventions

DEVICE

No Results Yet

NCT06109181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

10 Participants

Gene Therapy for ACM Due to a PKP2 Pathogenic Variant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-29

Completion: 2026-12-31

Conditions

Arrhythmogenic Cardiomyopathy PKP2-ACM PKP2-ARVC

Interventions

GENETIC

No Results Yet

NCT06098079 | RECRUITING | PHASE4

8600 Participants

Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-03

Completion: 2029-01-31

Conditions

Obesity

Interventions

DRUG

No Results Yet

NCT06095505 | RECRUITING | PHASE2

80 Participants

A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-08

Completion: 2027-04-30

Conditions

Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06087640 | RECRUITING | PHASE3

35800 Participants

A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-23

Completion: 2026-11-30

Conditions

Influenza, Human

Interventions

BIOLOGICAL

No Results Yet

NCT06077500 | ACTIVE_NOT_RECRUITING | PHASE1

46 Participants

DAREONᵀᴹ-8: A Study to Test How Well Different Doses of BI 764532 in Addition to Standard of Care Are Tolerated by People With Advanced Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-14

Completion: 2025-12-01

Conditions

Small Cell Lung Carcinoma (SCLC)

Interventions

DRUG

No Results Yet

NCT06074588 | RECRUITING | PHASE3

556 Participants

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-12

Completion: 2027-05-10

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06073821 | ACTIVE_NOT_RECRUITING | PHASE3

652 Participants

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-11

Completion: 2032-02-29

Conditions

CLL

Interventions

DRUG

No Results Yet

NCT06067347 | RECRUITING

1200 Participants

A Global Study of the PETAL Consortium

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-05

Completion: 2028-01-31

Conditions

T-Cell and NK-Cell Neoplasm

No Results Yet

NCT06064097 | RECRUITING | PHASE2

50 Participants

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-06-25

Completion: 2026-12-31

Conditions

Stage II Nasopharyngeal Carcinoma AJCC v8 Stage III Nasopharyngeal Carcinoma AJCC v8 Stage IV Nasopharyngeal Carcinoma AJCC v8

Interventions

PROCEDURE DRUG OTHER BIOLOGICAL RADIATION

No Results Yet

NCT06062368 | RECRUITING | NA

100 Participants

Reducing Vertigo Associated With MRI Machines

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-15

Completion: 2027-01-01

Conditions

Vertigo Dizziness

Interventions

BEHAVIORAL

No Results Yet

NCT06059586 | RECRUITING | NA

20 Participants

Pre-Rehabilitation for Female Patients Undergoing Pelvic Radiotherapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-16

Completion: 2026-01-31

Conditions

Dyspareunia Pelvic Pain Sexual Dysfunction Radiation Toxicity

Interventions

BEHAVIORAL DEVICE

No Results Yet

NCT06058793 | ACTIVE_NOT_RECRUITING | PHASE3

138 Participants

Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-12-13

Completion: 2025-11-21

Conditions

Liposarcoma, Dedifferentiated

Interventions

DRUG

No Results Yet

NCT06058377 | RECRUITING | PHASE3

3680 Participants

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-27

Completion: 2026-05-31

Conditions

Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 HER2-Negative Breast Carcinoma Hormone Receptor-Positive Breast Carcinoma

Interventions

PROCEDURE DRUG BIOLOGICAL OTHER

No Results Yet

NCT06054412 | ACTIVE_NOT_RECRUITING | NA

20 Participants

An Adjunctive Neurofeedback Training Program to Enhance Wellness Among Trauma-Exposed Postpartum Mothers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-03-03

Completion: 2025-09-01

Conditions

Well-Being, Psychological Dissociation Maternal Care Patterns Maternal Behavior Maternal Distress Mood Disturbance Emotional Regulation Post Traumatic Stress Disorder

Interventions

DEVICE

No Results Yet

NCT06038838 | RECRUITING | NA

30 Participants

Feasibility Study of the Tioga TMVR System

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-04-01

Completion: 2026-07-01

Conditions

Mitral Regurgitation

Interventions

DEVICE

No Results Yet

NCT06034405 | RECRUITING

1663 Participants

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-19

Completion: 2026-05-31

Conditions

Lumbar Spinal Stenosis Cardiac Amyloidosis ATTR Amyloidosis Wild Type ATTR Gene Mutation ATTRV122I Amyloidosis Cardiomyopathy, Hypertrophic

Interventions

DIAGNOSTIC_TEST

No Results Yet

NCT06021704 | NOT_YET_RECRUITING | NA

120 Participants

The Care for America's Aging Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-12-01

Completion: 2027-11-30

Conditions

Cognitive Impairment Dementia With Behavioral Disturbance Dementia Alzheimer Disease

Interventions

BEHAVIORAL

No Results Yet

NCT06012240 | RECRUITING | PHASE3

1500 Participants

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-11

Completion: 2028-01-31

Conditions

Alopecia Areata

Interventions

DRUG

No Results Yet

NCT06011239 | COMPLETED | NA

614 Participants

Family Teams: A Study to Promote Team Collaboration in Family Medicine Clinics

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-08

Completion: 2025-10-20

Conditions

Patient Care Team Psychological Well-Being Occupational Burnout

Interventions

BEHAVIORAL

No Results Yet

NCT06002165 | ENROLLING_BY_INVITATION | NA

4000 Participants

Testing Implementation Strategies to Support Clinic Fidelity to an Outpatient Hypertension Bundle

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-04

Completion: 2027-06-30

Conditions

Pregnancy Related Hypertension

Interventions

BEHAVIORAL

No Results Yet

NCT05975983 | RECRUITING | PHASE2

40 Participants

Study Evaluating INS018_055 Administered Orally to Subjects With Idiopathic Pulmonary Fibrosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-08

Completion: 2026-02-28

Conditions

Idiopathic Pulmonary Fibrosis (IPF)

Interventions

DRUG

No Results Yet

NCT05975593 | RECRUITING | NA

60 Participants

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-11

Completion: 2032-12-31

Conditions

Locally Advanced Cervical Carcinoma Locally Advanced Cervical Cancer Locally Advanced Pancreas Cancer Locally Advanced Pancreatic Carcinoma Locally Advanced Pancreatic Cancer Cervical Cancer Pancreas Cancer Pancreatic Cancer Cancer of the Cervix Cancer of the Pancreas

Interventions

OTHER DEVICE

No Results Yet

NCT05970406 | ENROLLING_BY_INVITATION | NA

60 Participants

High Intensity Dysphagia Rehab for Acute Ischemic Stroke Patients

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-30

Completion: 2026-11-30

Conditions

Dysphagia Following Cerebrovascular Accident

Interventions

OTHER

No Results Yet

NCT05968638 | ACTIVE_NOT_RECRUITING | NA

50 Participants

Ketogenic Diet in People With Schizophrenia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-01

Completion: 2026-08-01

Conditions

Schizophrenia Schizo Affective Disorder

Interventions

OTHER

No Results Yet

NCT05965713 | ACTIVE_NOT_RECRUITING | NA

80 Participants

National Fully Remote Use of IpsiHand Device in Hemiparetic Stroke

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-01

Completion: 2025-09-12

Conditions

Stroke Hemiparesis Spasticity as Sequela of Stroke Brain Computer Interface

Interventions

DEVICE OTHER

No Results Yet

NCT05952037 | RECRUITING | PHASE2

105 Participants

A Study to Investigate Efficacy and Safety of BCL2 Inhibitor Sonrotoclax as Monotherapy and in Combination With Zanubrutinib in Adults With Waldenström Macroglobulinemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-28

Completion: 2026-12-31

Conditions

Waldenstrom Macroglobulinemia Waldenstrom's Macroglobulinemia Recurrent Waldenstrom's Macroglobulinemia Refractory

Interventions

DRUG

No Results Yet

NCT05949047 | RECRUITING | NA

270 Participants

Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-14

Completion: 2026-11-30

Conditions

Caregivers Emotions Emotion Regulation Stress Psychological Psychophysiology

Interventions

BEHAVIORAL

No Results Yet

NCT05948943 | RECRUITING | PHASE2/PHASE3

232 Participants

Alpelisib in Pediatric and Adult Patients With Lymphatic Malformations Associated With a PIK3CA Mutation.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-24

Completion: 2028-05-31

Conditions

Lymphatic Malformations

Interventions

DRUG

No Results Yet

NCT05946941 | RECRUITING | PHASE3

756 Participants

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-11

Completion: 2026-11-18

Conditions

Sjögren's Syndrome

Interventions

DRUG OTHER

No Results Yet

NCT05939414 | RECRUITING | PHASE3

450 Participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-03-12

Completion: 2028-04-25

Conditions

Oligometastatic Prostate Cancer (OMPC)

Interventions

DRUG

No Results Yet

NCT05936996 | COMPLETED

258 Participants

Prospective Clinical Registry Evaluating Contemporary MANTA Outcomes

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-15

Completion: 2025-06-20

Conditions

Femoral Arteriotomy Closure

Interventions

DEVICE

No Results Yet

NCT05935748 | TERMINATED | PHASE2

18 Participants

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-07-28

Completion: 2025-06-30

Conditions

ccRCC Clear Cell Renal Cell Carcinoma Kidney Cancer Kidney Neoplasms Renal Cancer Renal Neoplasms Recurrent Renal Cell Carcinoma Metastatic Renal Cell Carcinoma Refractory Renal Cell Carcinoma Advanced Renal Cell Carcinoma Carcinoma Neoplasms Carcinoma, Renal Cell Neoplasms, Glandular and Epithelial Neoplasm by Histology Adenocarcinoma Urologic Neoplasms Urogenital Neoplasms Neoplasms by Site Kidney Diseases Urologic Diseases

Interventions

DRUG OTHER

No Results Yet

NCT05916313 | ACTIVE_NOT_RECRUITING | PHASE1

18 Participants

A Study to Test How Well Different Doses of BI 764532 Are Tolerated by People With a Tumour in the Brain That is Positive for DLL3

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-30

Completion: 2026-02-23

Conditions

Glioma

Interventions

DRUG

No Results Yet

NCT05906095 | ENROLLING_BY_INVITATION | NA

10160 Participants

Pragmatic Trial to Increase Quality of Care in State Veterans Homes

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-08

Completion: 2026-07-31

Conditions

Long-Term Care Accidental Falls

Interventions

BEHAVIORAL

No Results Yet