Evaluation of the Aurora Xi New Nomogram Software 2.0

NCT ID: NCT06122935

Last Updated: 2025-11-12

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6735 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-11-27

Study Completion Date

2024-05-31

Brief Summary

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A clinical trial to evaluate the safety and effectiveness of the Aurora Xi Plasmapheresis System with a new plasma collection volume nomogram.

Detailed Description

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A controlled, prospective, randomized, multicenter, IDE clinical trial to evaluate the safety and effectiveness of a new plasma collection volume nomogram on the Aurora Xi Plasmapheresis System (test arm) as compared to the currently marketed Optimized Nomogram on the Aurora Xi Plasmapheresis System (control arm). The new plasma collection volume nomogram will provide a more individualized approach to determining the volume of plasma collected from each donor. The trial will be conducted at a minimum of 3 plasma collection centers. Subjects will be randomized into the test and control arms.

Conditions

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Apheresis Related Hypotension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Test Group

Plasma collection using a new plasma collection volume nomogram (software version 2.0) for the Aurora Xi Plasmapheresis System

Group Type EXPERIMENTAL

Aurora Xi New Nomogram Software 2.0

Intervention Type DEVICE

Plasma collection with a proprietary plasma collection volume nomogram provides a more individualized approach to determining the volume of plasma collected from each donor.

Control Group

Plasma collection using the marketed (version 1.3) of AuroraXi Plasmapheresis System

Group Type ACTIVE_COMPARATOR

Aurora Xi Currently Approved Software 1.3

Intervention Type DEVICE

Plasma collection using the currently marketed Optimized Nomogram (software version 1.3) for the Aurora Xi Plasmapheresis System

Interventions

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Aurora Xi New Nomogram Software 2.0

Plasma collection with a proprietary plasma collection volume nomogram provides a more individualized approach to determining the volume of plasma collected from each donor.

Intervention Type DEVICE

Aurora Xi Currently Approved Software 1.3

Plasma collection using the currently marketed Optimized Nomogram (software version 1.3) for the Aurora Xi Plasmapheresis System

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* All subjects must meet current safety guidelines for plasma donation as set forth by the FDA as well as those in the standard operating procedures established by the participating institution.

Exclusion Criteria

* Subjects not able or unwilling to give consent to participate.
* Subjects withdrawn by a qualified healthcare provider due to safety concerns.
* Subjects who are employed by the clinical site or Sponsor.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fenwal, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Carrie Pineda

Role: STUDY_DIRECTOR

Fresenius Kabi

Locations

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BioLife Plasma Services

Lakeland, Florida, United States

Site Status

BioLife Plasma Services

West Des Moines, Iowa, United States

Site Status

BioLife Plasma Services

American Fork, Utah, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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PAND-004-CMD

Identifier Type: -

Identifier Source: org_study_id