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Clinical Trials

NCT04479072 | RECRUITING | PHASE4
180 Participants

Aspirin and Preeclampsia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-02-15
Completion: 2026-03-01
Conditions
Preeclampsia Postpartum
Interventions
DRUG
No Results Yet
NCT04472338 | RECRUITING
450 Participants

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-05-21
Completion: 2030-08-31
Conditions
Prostate Carcinoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT04463719 | COMPLETED | NA
107 Participants

AIM2: Adequate Selection of Patients for Thyroid Biopsy: Evaluation of a Shared Decision Making Conversation Aid

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2022-02-20
Completion: 2024-09-30
Conditions
Thyroid Nodules Thyroid Cancer
Interventions
BEHAVIORAL
Results Available
NCT04434092 | ACTIVE_NOT_RECRUITING | PHASE3
210 Participants

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-08
Completion: 2022-11-16
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
Results Available
NCT04429061 | COMPLETED | NA
2153 Participants

Reaching 90 90 90 in Adolescents in Zambia: Using All Our SKILLZ

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-02-01
Completion: 2022-12-31
Conditions
HIV Infections Pregnancy Related STI Mental Health Wellness 1
Interventions
BEHAVIORAL
Results Available
NCT04381897 | NOT_YET_RECRUITING | PHASE2
10 Participants

Use of N-Acetylcysteine in the Treatment of Repetitive and Self-Injurious Behaviors in Cornelia de Lange Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2026-03-01
Completion: 2027-05-01
Conditions
Cornelia de Lange Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT04374877 | COMPLETED | PHASE1
145 Participants

Study of CHS-388 (Formerly Known as SRF388) in Patients With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-22
Completion: 2025-05-28
Conditions
Advanced Solid Tumor Clear Cell Renal Cell Carcinoma Hepatocellular Carcinoma Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT04374786 | TERMINATED | NA
7 Participants

Effects of Mobile App in House Staff Health and Well-being During COVID-19 Pandemic

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-05-15
Completion: 2020-07-15
Conditions
Perceived Stress Anxiety Sleep Disturbance Burnout PTSD
Interventions
DEVICE
No Results Yet
NCT04372108 | RECRUITING
1056 Participants

A Study to Assess the Long-Term Safety of Ustekinumab Versus Other Biologics in Patients With Crohn's Disease and Ulcerative Colitis

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2021-06-24
Completion: 2029-08-31
Conditions
Crohn Disease Colitis, Ulcerative
Interventions
DRUG
No Results Yet
NCT04371315 | RECRUITING
400 Participants

Risk Factors, Clinical Characteristics and Outcomes of Acute Infection With Coronavirus 2019 (COVID-19) In Children

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-27
Completion: 2025-12-01
Conditions
Corona Virus Infection Pediatric Cancer Adult Children Cancer
No Results Yet
NCT04355832 | WITHDRAWN | EARLY_PHASE1
0 Participants

Glucagon-like Peptide-1 in Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-06-24
Completion: 2025-09-24
Conditions
Type1 Diabetes Mellitus
Interventions
DRUG
No Results Yet
NCT04333537 | RECRUITING | PHASE2/PHASE3
686 Participants

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-09-23
Completion: 2031-04-27
Conditions
Buccal Mucosa Squamous Cell Carcinoma Floor of Mouth Squamous Cell Carcinoma Gingival Squamous Cell Carcinoma Hard Palate Squamous Cell Carcinoma Lip Squamous Cell Carcinoma Lower Alveolar Ridge Squamous Cell Carcinoma Oral Cavity Squamous Cell Carcinoma Retromolar Trigone Squamous Cell Carcinoma Stage I Lip and Oral Cavity Cancer AJCC v8 Stage II Lip and Oral Cavity Cancer AJCC v8 Tongue Squamous Cell Carcinoma Upper Alveolar Ridge Squamous Cell Carcinoma
Interventions
PROCEDURE OTHER DRUG
No Results Yet
NCT04329494 | RECRUITING | PHASE1
49 Participants

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-08-21
Completion: 2028-01-05
Conditions
Clinical Stage IV Gastric Cancer AJCC v8 Clinical Stage IVA Gastric Cancer AJCC v8 Clinical Stage IVB Gastric Cancer AJCC v8 Malignant Uterine Neoplasm Metastatic Appendix Carcinoma Metastatic Colorectal Carcinoma Metastatic Gastric Carcinoma Metastatic Malignant Neoplasm in the Peritoneum Metastatic Malignant Solid Neoplasm Metastatic Ovarian Carcinoma Pathologic Stage IV Gastric Cancer AJCC v8 Peritoneal Carcinomatosis Postneoadjuvant Therapy Stage IV Gastric Cancer AJCC v8 Stage IV Appendix Carcinoma AJCC v8 Stage IV Colorectal Cancer AJCC v8 Stage IV Ovarian Cancer AJCC v8 Stage IV Uterine Corpus Cancer AJCC v8 Stage IVA Appendix Carcinoma AJCC v8 Stage IVA Colorectal Cancer AJCC v8 Stage IVA Ovarian Cancer AJCC v8 Stage IVA Uterine Corpus Cancer AJCC v8 Stage IVB Appendix Carcinoma AJCC v8 Stage IVB Colorectal Cancer AJCC v8 Stage IVB Ovarian Cancer AJCC v8 Stage IVB Uterine Corpus Cancer AJCC v8 Stage IVC Appendix Carcinoma AJCC v8 Stage IVC Colorectal Cancer AJCC v8
Interventions
PROCEDURE DRUG DEVICE OTHER
No Results Yet
NCT04327635 | COMPLETED | PHASE1
9 Participants

Safety Evaluation of Intracoronary Infusion of Extracellular Vesicles in Patients Following Coronary Stent Implantation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-11-02
Completion: 2025-10-22
Conditions
Percutaneous Coronary Intervention
Interventions
DRUG
No Results Yet
NCT04324112 | RECRUITING | PHASE2
45 Participants

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-10-28
Completion: 2028-04-30
Conditions
Hairy Cell Leukemia
Interventions
DRUG
No Results Yet
NCT04312672 | ACTIVE_NOT_RECRUITING
42 Participants

Long-term Follow-up Gene Therapy Study for RPGR- XLRP

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2017-07-31
Completion: 2026-11-18
Conditions
X-Linked Retinitis Pigmentosa
Interventions
BIOLOGICAL
No Results Yet
NCT04306237 | WITHDRAWN | PHASE2
0 Participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Refractory Angina

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-05-01
Completion: 2025-02-28
Conditions
Refractory Angina
Interventions
DRUG
No Results Yet
NCT04299867 | COMPLETED
21 Participants

Perioperative Tissue Penetration of Antimicrobials in Infants

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-07-15
Completion: 2022-03-26
Conditions
Bowel Dysfunction
Interventions
PROCEDURE
No Results Yet
NCT04291612 | RECRUITING
1715 Participants

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-02-26
Completion: 2026-02-26
Conditions
Endometrial Cancer Endometrioid Adenocarcinoma Endometrial Cancer Stage I
Interventions
OTHER
No Results Yet
NCT04273945 | ACTIVE_NOT_RECRUITING | PHASE3
935 Participants

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-06-30
Completion: 2025-10-07
Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG
No Results Yet
NCT04253392 | ACTIVE_NOT_RECRUITING
500 Participants

RETHINK REFLUX Registry

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2020-07-08
Completion: 2032-07-31
Conditions
Gastroesophageal Reflux
Interventions
DEVICE
No Results Yet
NCT04239989 | TERMINATED | PHASE1
8 Participants

Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-10-08
Completion: 2025-10-31
Conditions
Bronchiolitis Obliterans
Interventions
DRUG
No Results Yet
NCT04227184 | COMPLETED | PHASE4
207 Participants

Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-02-13
Completion: 2025-02-28
Conditions
Urgency Urinary Incontinence
Interventions
DRUG
No Results Yet
NCT04209790 | TERMINATED | PHASE2
2 Participants

Neoadjuvant Chemoradiation for Resectable Glioblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-01
Completion: 2022-09-14
Conditions
Glioblastoma Surgery High Grade Glioma
Interventions
RADIATION DRUG PROCEDURE
Results Available
NCT04208178 | ACTIVE_NOT_RECRUITING | PHASE3
20 Participants

Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-07-16
Completion: 2026-06-16
Conditions
Advanced HER2+Breast Cancer
Interventions
DRUG
No Results Yet
NCT04195633 | RECRUITING | PHASE2
60 Participants

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2021-01-25
Completion: 2026-02-19
Conditions
Acute Leukemia Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Adult Diffuse Large Cell Lymphoma Anaplastic Large Cell Lymphoma Burkitt Lymphoma Chronic Myeloid Leukemia, BCR-ABL1 Positive Chronic Myelomonocytic Leukemia Hodgkin Lymphoma Lymphoblastic Lymphoma Lymphoplasmacytic Lymphoma Mantle Cell Lymphoma Mixed Phenotype Acute Leukemia Myelodysplastic Syndrome Prolymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Refractory Follicular Lymphoma Refractory Marginal Zone Lymphoma Refractory Small Lymphocytic Lymphoma
Interventions
PROCEDURE DRUG BIOLOGICAL RADIATION
No Results Yet
NCT04181684 | RECRUITING | NA
32 Participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-01-08
Completion: 2025-12-31
Conditions
Glioblastoma Brain Tumor Glioma Neoplasms
Interventions
DEVICE RADIATION
No Results Yet
NCT04178551 | COMPLETED | NA
63 Participants

Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-10-01
Completion: 2022-09-30
Conditions
Opioid Medication Assisted Treatment
Interventions
OTHER
Results Available
NCT04175613 | ACTIVE_NOT_RECRUITING | PHASE3
160 Participants

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-12-20
Completion: 2025-10-30
Conditions
Psoriasis
Interventions
DRUG
No Results Yet
NCT04175600 | ACTIVE_NOT_RECRUITING | PHASE3
138 Participants

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-01-16
Completion: 2024-10-11
Conditions
Hypertension, Pulmonary
Interventions
DRUG
No Results Yet
NCT04173884 | COMPLETED | NA
59 Participants

Video-based Collaborative Learning to Improve Ventral Hernia Repair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-09-01
Completion: 2025-05-31
Conditions
Ventral Hernia
Interventions
OTHER
No Results Yet
NCT04165070 | RECRUITING | PHASE1/PHASE2
450 Participants

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naรฏve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-12-19
Completion: 2032-02-13
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04164472 | COMPLETED | NA
5250 Participants

NIH R01 Friend to Friend With Coaching

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-11-12
Completion: 2025-06-30
Conditions
Aggression
Interventions
BEHAVIORAL
No Results Yet
NCT04160429 | RECRUITING
100 Participants

Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2018-11-09
Completion: 2029-07-30
Conditions
Chronic Disease Infectious Disorder
Interventions
PROCEDURE OTHER
No Results Yet
NCT04134260 | RECRUITING | PHASE3
586 Participants

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-04-16
Completion: 2026-11-01
Conditions
Prostate Adenocarcinoma Stage I Prostate Cancer AJCC v8 Stage II Prostate Cancer AJCC v8 Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8
Interventions
DRUG PROCEDURE OTHER RADIATION
No Results Yet
NCT04133636 | RECRUITING | PHASE2
237 Participants

A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-11-07
Completion: 2026-08-04
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT04128670 | RECRUITING | NA
36 Participants

Effects of Kinesio Tape on Delayed Onset Muscle Soreness

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-01-30
Completion: 2026-05-30
Conditions
Delayed Onset Muscle Soreness
Interventions
DEVICE
No Results Yet
NCT04123795 | RECRUITING | PHASE3
150 Participants

A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2020-01-21
Completion: 2029-09-19
Conditions
Moderate Chronic Plaque Psoriasis Severe Chronic Plaque Psoriasis Mixed Guttate/Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT04119050 | RECRUITING | PHASE2/PHASE3
111 Participants

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2019-08-15
Completion: 2025-02-02
Conditions
Warm Autoimmune Hemolytic Anemia
Interventions
DRUG
No Results Yet
NCT04115241 | RECRUITING
200 Participants

Activity Levels in Bone Marrow Transplant Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2019-05-23
Completion: 2030-05-23
Conditions
Bone Marrow Transplant
Interventions
DEVICE OTHER
No Results Yet
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