RETHINK REFLUX Registry

NCT ID: NCT04253392

Last Updated: 2025-11-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-08

Study Completion Date

2032-07-31

Brief Summary

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The RETHINK REFLUX Registry is a post-market prospective, multi-center, observation, single arm, long-term safety surveillance registry of subjects implanted with the LINX device. The primary objective of the study is to confirm the long-term safety profile of the LINX device and procedure (implant/explant) up to 10 years post-implant.

Detailed Description

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The RETHINK REFLUX Registry or Research to further inform thinking about the role of LINX for Reflux Disease is sponsored by Ethicon Endo-Surgery, Inc. This is a post-market prospective, multi-center, observational, single arm, long-term safety surveillance registry of subjects implanted with the LINX device. Up to 500 subjects will be enrolled and implanted at up to 50 centers in both the US and selected countries outside the US with regulatory approval for the LINX Reflux Management System. The study will collect data from patients 10 years post implant. The primary objective of the study is to confirm the long-term safety profile of the LINX device and procedure (implant/explant). Secondary objectives include Effectiveness, Health Economics and Health Utilization.

Conditions

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Gastroesophageal Reflux

Keywords

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Gastroesophageal Reflux Disease GERD Reflux Regurgitation Esophageal Disease Lower Esophageal Sphincter LES Magnetic Sphincter Augmentation MSA

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Interventions

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LINX Reflux Management System

The LINX Reflux Management System consists of a series of titanium beads each with a magnetic core connected with independent titanium wires to form an annular shape when implanted. The attractive force of the magnetic beads is designed to provide additional strength to keep a weak lower esophageal sphincter (LES) closed. During swallowing, the magnetic beads slide away from each other on the independent titanium wire "links" to allow esophageal distention as the bolus passes by.

Intervention Type DEVICE

Other Intervention Names

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LINX

Eligibility Criteria

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Inclusion Criteria

1. Subject is \>or=21 years old
2. Subject with prospective plans for a LINX procedure
3. Subject provides written informed consent
4. Subject must be willing and able to complete questionnaires/ surveys electronically (ePROs)

Exclusion Criteria

1. Subject who was previously implanted with LINX device
2. Any reason which the Principal Investigator believes may cause the subject to be non-compliant with or unable to meet the protocol requirements (i.e. medical illness and/or limited life expectancy of less than 10 years)

Note: Physicians should refer to the LINX Reflux Management System IFU for a complete list of contraindications, warnings, and precautions.
Minimum Eligible Age

21 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ethicon Endo-Surgery

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jörg Tomaszewski, MD

Role: STUDY_DIRECTOR

Ethicon Endo-Surgery

Locations

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University of South Alabama

Mobile, Alabama, United States

Site Status

NW Allied Bariatric and Foregut Surgery

Tucson, Arizona, United States

Site Status

Keck Hospital of USC

Los Angeles, California, United States

Site Status

Institute of Esophageal and Reflux Surgery

Englewood, Colorado, United States

Site Status

University of Southern Florida (Tampa General Hospital)

Tampa, Florida, United States

Site Status

OSF Medical Group

Peoria, Illinois, United States

Site Status

Saint Elizabeth Healthcare Edgewood

Edgewood, Kentucky, United States

Site Status

Sparrow Hospital / Sparrow Medical Group

Lansing, Michigan, United States

Site Status

East Carolina University / Vidant Medical Center

Greenville, North Carolina, United States

Site Status

The Ohio State University

Columbus, Ohio, United States

Site Status

Gen Surg Assoc / Fairfield Medical Center

Lancaster, Ohio, United States

Site Status

Lehigh Valley Hospital - Cedar Crest

Allentown, Pennsylvania, United States

Site Status

Minimal Access Surgery/Prisma Health - Upstate

Greenville, South Carolina, United States

Site Status

Adv Surg Assoc / Self Regional Healthcare

Greenwood, South Carolina, United States

Site Status

Lexington Surgery

West Columbia, South Carolina, United States

Site Status

Panhandle Weight Loss Center

Amarillo, Texas, United States

Site Status

Houston Methodist

Houston, Texas, United States

Site Status

Bariatric Medical Institute of Texas

San Antonio, Texas, United States

Site Status

Richmond Surg / Henrico Doctors' Hospital

Richmond, Virginia, United States

Site Status

Swedish Medical Center

Seattle, Washington, United States

Site Status

Fox Valley Surgical Associates

Appleton, Wisconsin, United States

Site Status

MedUni Wien / Universitatsklinik fur Chirurgie

Vienna, , Austria

Site Status

Marien Hospital Herne

Herne, , Germany

Site Status

Univ of Milano / IRCCS Policlinico San Donato

San Donato Milanese, , Italy

Site Status

National University Hospital

Singapore, , Singapore

Site Status

Epsom Hospital

Epsom, , United Kingdom

Site Status

Guy's and St. Thomas' Hospitals

London, , United Kingdom

Site Status

RefluxUK

Royal Tunbridge Wells, , United Kingdom

Site Status

Countries

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United States Austria Germany Italy Singapore United Kingdom

Other Identifiers

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TRX_2018_01

Identifier Type: -

Identifier Source: org_study_id