Clinical Trials

NCT04327635 | COMPLETED | PHASE1

9 Participants

Safety Evaluation of Intracoronary Infusion of Extracellular Vesicles in Patients Following Coronary Stent Implantation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2021-11-02

Completion: 2025-10-22

Conditions

Percutaneous Coronary Intervention

Interventions

DRUG

No Results Yet

NCT04324112 | RECRUITING | PHASE2

45 Participants

Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-10-28

Completion: 2028-04-30

Conditions

Hairy Cell Leukemia

Interventions

DRUG

No Results Yet

NCT04312672 | ACTIVE_NOT_RECRUITING

42 Participants

Long-term Follow-up Gene Therapy Study for RPGR- XLRP

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2017-07-31

Completion: 2026-11-18

Conditions

X-Linked Retinitis Pigmentosa

Interventions

BIOLOGICAL

No Results Yet

NCT04306237 | WITHDRAWN | PHASE2

0 Participants

A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Refractory Angina

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-05-01

Completion: 2025-02-28

Conditions

Refractory Angina

Interventions

DRUG

No Results Yet

NCT04299867 | COMPLETED

21 Participants

Perioperative Tissue Penetration of Antimicrobials in Infants

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2020-07-15

Completion: 2022-03-26

Conditions

Bowel Dysfunction

Interventions

PROCEDURE

No Results Yet

NCT04291612 | RECRUITING

1715 Participants

Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2020-02-26

Completion: 2026-02-26

Conditions

Endometrial Cancer Endometrioid Adenocarcinoma Endometrial Cancer Stage I

Interventions

OTHER

No Results Yet

NCT04273945 | ACTIVE_NOT_RECRUITING | PHASE3

935 Participants

Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-06-30

Completion: 2025-10-07

Conditions

Pulmonary Arterial Hypertension

Interventions

DRUG

No Results Yet

NCT04253392 | ACTIVE_NOT_RECRUITING

500 Participants

RETHINK REFLUX Registry

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2020-07-08

Completion: 2032-07-31

Conditions

Gastroesophageal Reflux

Interventions

DEVICE

No Results Yet

NCT04239989 | TERMINATED | PHASE1

8 Participants

Itacitinib for the Treatment of Bronchiolitis Obliterans Syndrome After Donor Hematopoietic Cell Transplant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2021-10-08

Completion: 2025-10-31

Conditions

Bronchiolitis Obliterans

Interventions

DRUG

No Results Yet

NCT04227184 | COMPLETED | PHASE4

207 Participants

Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-02-13

Completion: 2025-02-28

Conditions

Urgency Urinary Incontinence

Interventions

DRUG

No Results Yet

NCT04209790 | TERMINATED | PHASE2

2 Participants

Neoadjuvant Chemoradiation for Resectable Glioblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-04-01

Completion: 2022-09-14

Conditions

Glioblastoma Surgery High Grade Glioma

Interventions

RADIATION DRUG PROCEDURE

Results Available

NCT04208178 | ACTIVE_NOT_RECRUITING | PHASE3

20 Participants

Study of Alpelisib (BYL719) in Combination With Trastuzumab and Pertuzumab as Maintenance Therapy in Patients With HER2-positive Advanced Breast Cancer With a PIK3CA Mutation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-07-16

Completion: 2026-06-16

Conditions

Advanced HER2+Breast Cancer

Interventions

DRUG

No Results Yet

NCT04195633 | RECRUITING | PHASE2

60 Participants

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2021-01-25

Completion: 2026-02-19

Conditions

Acute Leukemia Acute Lymphoblastic Leukemia Acute Myeloid Leukemia Adult Diffuse Large Cell Lymphoma Anaplastic Large Cell Lymphoma Burkitt Lymphoma Chronic Myeloid Leukemia, BCR-ABL1 Positive Chronic Myelomonocytic Leukemia Hodgkin Lymphoma Lymphoblastic Lymphoma Lymphoplasmacytic Lymphoma Mantle Cell Lymphoma Mixed Phenotype Acute Leukemia Myelodysplastic Syndrome Prolymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Refractory Follicular Lymphoma Refractory Marginal Zone Lymphoma Refractory Small Lymphocytic Lymphoma

Interventions

PROCEDURE DRUG BIOLOGICAL RADIATION

No Results Yet

NCT04181684 | RECRUITING | NA

32 Participants

LITT Followed by Hypofractionated RT for Recurrent Gliomas

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-01-08

Completion: 2025-12-31

Conditions

Glioblastoma Brain Tumor Glioma Neoplasms

Interventions

DEVICE RADIATION

No Results Yet

NCT04178551 | COMPLETED | NA

63 Participants

Consortium to Disseminate and Understand Implementation of Opioid Use Disorder Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-10-01

Completion: 2022-09-30

Conditions

Opioid Medication Assisted Treatment

Interventions

OTHER

Results Available

NCT04175613 | ACTIVE_NOT_RECRUITING | PHASE3

160 Participants

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-12-20

Completion: 2025-10-30

Conditions

Psoriasis

Interventions

DRUG

No Results Yet

NCT04175600 | ACTIVE_NOT_RECRUITING | PHASE3

138 Participants

A Study of Selexipag as Add-On Treatment to Standard of Care in Children With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-01-16

Completion: 2024-10-11

Conditions

Hypertension, Pulmonary

Interventions

DRUG

No Results Yet

NCT04173884 | COMPLETED | NA

59 Participants

Video-based Collaborative Learning to Improve Ventral Hernia Repair

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-09-01

Completion: 2025-05-31

Conditions

Ventral Hernia

Interventions

OTHER

No Results Yet

NCT04165070 | RECRUITING | PHASE1/PHASE2

450 Participants

KEYMAKER-U01 Substudy 01A: Efficacy and Safety Study of Pembrolizumab (MK-3475) With or Without Chemotherapy When Used With Investigational Agents in Treatment-naïve Participants With Stage IV Non-small Cell Lung Cancer (NSCLC) (MK-3475-01A/KEYMAKER-U01A)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-12-19

Completion: 2032-02-13

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT04164472 | COMPLETED | NA

5250 Participants

NIH R01 Friend to Friend With Coaching

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-11-12

Completion: 2025-06-30

Conditions

Aggression

Interventions

BEHAVIORAL

No Results Yet

NCT04160429 | RECRUITING

100 Participants

Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2018-11-09

Completion: 2029-07-30

Conditions

Chronic Disease Infectious Disorder

Interventions

PROCEDURE OTHER

No Results Yet

NCT04134260 | RECRUITING | PHASE3

586 Participants

Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer, INNOVATE Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-04-16

Completion: 2026-11-01

Conditions

Prostate Adenocarcinoma Stage I Prostate Cancer AJCC v8 Stage II Prostate Cancer AJCC v8 Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8

Interventions

DRUG PROCEDURE OTHER RADIATION

No Results Yet

NCT04133636 | RECRUITING | PHASE2

237 Participants

A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-11-07

Completion: 2026-08-04

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04128670 | RECRUITING | NA

36 Participants

Effects of Kinesio Tape on Delayed Onset Muscle Soreness

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-01-30

Completion: 2026-05-30

Conditions

Delayed Onset Muscle Soreness

Interventions

DEVICE

No Results Yet

NCT04123795 | RECRUITING | PHASE3

150 Participants

A Study to Evaluate the Pharmacokinetics, Safety, and Effectiveness of Certolizumab Pegol in Children With Moderate to Severe Chronic Plaque Psoriasis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-01-21

Completion: 2029-09-19

Conditions

Moderate Chronic Plaque Psoriasis Severe Chronic Plaque Psoriasis Mixed Guttate/Plaque Psoriasis

Interventions

DRUG

No Results Yet

NCT04119050 | RECRUITING | PHASE2/PHASE3

111 Participants

Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-08-15

Completion: 2025-02-02

Conditions

Warm Autoimmune Hemolytic Anemia

Interventions

DRUG

No Results Yet

NCT04115241 | RECRUITING

200 Participants

Activity Levels in Bone Marrow Transplant Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2019-05-23

Completion: 2030-05-23

Conditions

Bone Marrow Transplant

Interventions

DEVICE OTHER

No Results Yet

NCT04114084 | RECRUITING

200 Participants

Sleep Apnea in Patients With MGUS and MM

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2019-05-23

Completion: 2030-05-23

Conditions

Multiple Myeloma Monoclonal Gammopathy of Undetermined Significance

Interventions

PROCEDURE

No Results Yet

NCT04108195 | ACTIVE_NOT_RECRUITING | PHASE1

290 Participants

A Study of Subcutaneous Daratumumab Regimens in Combination With Bispecific T Cell Redirection Antibodies for the Treatment of Participants With Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-02-21

Completion: 2027-04-07

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT04077463 | ACTIVE_NOT_RECRUITING | PHASE1

701 Participants

A Study of Lazertinib as Monotherapy or in Combination With Amivantamab in Participants With Advanced Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-09-04

Completion: 2026-06-03

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

DRUG

No Results Yet

NCT04071223 | RECRUITING | PHASE2

134 Participants

Testing the Addition of a New Anti-cancer Drug, Radium-223 Dichloride, to the Usual Treatment (Cabozantinib) for Advanced Renal Cell Cancer That Has Spread to the Bone, RadiCaL Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-07-29

Completion: 2026-10-01

Conditions

Advanced Renal Cell Carcinoma Chromophobe Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Collecting Duct Carcinoma Kidney Medullary Carcinoma Metastatic Malignant Neoplasm in the Bone Papillary Renal Cell Carcinoma Stage IV Renal Cell Cancer AJCC v8 Unclassified Renal Cell Carcinoma

Interventions

PROCEDURE DRUG OTHER RADIATION

No Results Yet

NCT04067336 | RECRUITING | PHASE1/PHASE2

263 Participants

First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-09-12

Completion: 2028-10-16

Conditions

Advanced Malignant Neoplasm Acute Myeloid Leukemia Mixed Lineage Leukemia Mixed Lineage Acute Leukemia Acute Leukemia of Ambiguous Lineage Mixed Phenotype Acute Leukemia Acute Lymphoblastic Leukemia

Interventions

DRUG

No Results Yet

NCT04065399 | RECRUITING | PHASE1/PHASE2

413 Participants

A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-11-05

Completion: 2027-12-15

Conditions

Acute Myeloid Leukemia Acute Lymphoblastic Leukemia Mixed Lineage Acute Leukemia Mixed Phenotype Acute Leukemia Acute Leukemia of Ambiguous Lineage

Interventions

DRUG

No Results Yet

NCT04054154 | ACTIVE_NOT_RECRUITING | NA

27 Participants

An Investigational Device (Millar Mikro-Tip Catheter) and Imaging Scan (Shear Wave Elastography) in Measuring Tumor Pressure and Stiffness in Patients With Solid Tumors Undergoing Ultrasound-Guided Biopsy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2015-12-29

Completion: 2026-12-31

Conditions

Solid Neoplasm

Interventions

DEVICE PROCEDURE

No Results Yet

NCT04009499 | ACTIVE_NOT_RECRUITING | PHASE3

1131 Participants

A Study to Assess the Long-term Safety, Tolerability, and Efficacy of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-08-13

Completion: 2026-05-25

Conditions

Psoriatic Arthritis

Interventions

DRUG

No Results Yet

NCT03991962 | RECRUITING | PHASE2

28 Participants

Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2019-09-19

Completion: 2026-08-31

Conditions

Pancreatic Cancer

Interventions

DRUG RADIATION

No Results Yet

NCT03981055 | ACTIVE_NOT_RECRUITING | NA

40 Participants

Parkinson's Disease: Enhancing Physical Therapy With Brain Stimulation for Treating Postural Instability.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-01-23

Completion: 2024-04-30

Conditions

Parkinson Disease

Interventions

DEVICE OTHER

Results Available

NCT03975231 | RECRUITING | PHASE1

6 Participants

Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2020-09-14

Completion: 2026-02-28

Conditions

BRAF NP_004324.2:p.V600E BRAF V600K Mutation Present Thyroid Gland Anaplastic Carcinoma

Interventions

DRUG RADIATION

No Results Yet

NCT03955627 | COMPLETED | NA

12 Participants

REJOIN Trial for Older Breast Cancer Survivors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2021-06-15

Completion: 2025-07-29

Conditions

Breast Cancer Female

Interventions

BEHAVIORAL

No Results Yet

NCT03941756 | RECRUITING | NA

252 Participants

Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2018-08-14

Completion: 2025-12-31

Conditions

Anatomic Stage III Breast Cancer AJCC v8 Breast Inflammatory Carcinoma Locally Advanced Breast Carcinoma Melanoma

Interventions

DRUG PROCEDURE

No Results Yet