Molecular Mechanisms Underlying Hip and Knee Osteoarthritis in Patients Undergoing Primary Elective Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-11-22

Study Completion Date

2028-12-31

Brief Summary

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The aim of this observational study is to determine content of rare metals and other elements, along with the levels of selected immunological parameters, in the tissue of the hip or knee joint in the course of degenerative diseases. Determining potential disturbances in the levels or functions of these parameters may in the future contribute to improving treatment - for example, through supplementation of deficient metals or modulation at the immunological level. The main question it aims to answer is:

Are selected rare metals, trace elements and other selected immunological parameters lowered in the tissue of the hip or knee joint as well as in serum in the course of osteoarthritis?

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Detailed Description

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Conditions

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Total Hip Arthroplasty (THA) Total Knee Arthroplasty (TKA) Hip Osteoarthritis Knee Osteoarthristis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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patients undergoing primary total knee arthroplasty

No interventions assigned to this group

patients undergoing primary total hip arthroplasty

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 18 years old and more
* patient qualified for primary TKA or primary THA
* patient diagnosed with hip or knee osteoarthritis
* a complete set of tissues of good quality and volume is available

Exclusion Criteria

* lack of written consent to participate in the study or surgery
* any private or professional relationship with the Investigators
* genetic connective tissue diseases (e.g., Ehlers-Danlos syndrome and others)
* genetic metabolic diseases (e.g., gout and others)
* genetic diseases affecting the anatomy of the operated joint (e.g., dysplasia and others)
* previous surgeries altering the anatomy of the examined joint (e.g., periacetabular osteotomy, unicompartmental endoprosthesis, and others)
* patients undergoing revision after THA/TKA
* autoimmune diseases in the patient's medical history
* traumatic injury to the hip or knee joint
* previous participation in the study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No