Predicting Outcome of Total Knee Replacement Surgery in Patients With Knee Osteoarthritis
NCT ID: NCT05380648
Last Updated: 2023-12-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
223 participants
OBSERVATIONAL
2018-03-08
2023-07-14
Brief Summary
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In this study, the investigators will examine putative prognostic factors on the basis of the biopsychosocial model. Besides several psychological factors (measured with questionnaires), the investigators will assess structural impairments (such as radiographic severity of OA), functional impairments (muscle weakness and proprioceptive deficits), anesthetic procedures, immediate postoperative pain management, metabolic factors (body composition and hemoglobin A1c), inflammatory factors (C-Reactive Protein) and the investigators also will examine the role of altered central pain processing (CPP) (primary and secondary mechanical hyperalgesia, mechanical temporal summation, thermal primary and secondary hyperalgesia, endogenous pain modulation).
With a longitudinal study design, this study will explore which factors are predictive of poor outcome in knee OA patients after TKR. Moreover, the interrelationship between CPP, structural, functional, metabolic, inflammatory and psychological factors, and the clinical expression of knee OA (pain, symptoms, physical performance and quality of life) will be investigated.
Further research on the role of the aforementioned putative prognostic factors on postsurgical outcome could contribute to better management of these patients, since these factors may be particularly important for patient-tailored treatment.
Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Total knee arthroplasty
Total knee arthroplasty surgery will be performed by different orthopedist.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Patients who are not capable of understanding and speaking Dutch
* Revision surgery
40 Years
ALL
No
Sponsors
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Universiteit Antwerpen
OTHER
Responsible Party
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Sophie Vervullens
Doctoral student Sophie Vervullens
Principal Investigators
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Sophie Vervullens
Role: PRINCIPAL_INVESTIGATOR
Universiteit Antwerpen
Lotte Meert
Role: PRINCIPAL_INVESTIGATOR
Universiteit Antwerpen
Mira Meeus
Role: PRINCIPAL_INVESTIGATOR
Universiteit Antwerpen
Isabel Baert
Role: PRINCIPAL_INVESTIGATOR
Universiteit Antwerpen
Rob J.E.M. Smeets
Role: PRINCIPAL_INVESTIGATOR
Maastricht University
Locations
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University of Antwerp
Antwerp, , Belgium
Countries
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References
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Vervullens S, Meert L, Smeets RJEM, van der Nest G, Verbrugghe J, Verdonk P, Rahusen FTG, Meeus M. A biopsychosocial approach to phenotyping people with knee osteoarthritis awaiting total knee arthroplasty: A secondary cohort analysis. Ann Phys Rehabil Med. 2024 Nov;67(8):101895. doi: 10.1016/j.rehab.2024.101895. Epub 2024 Oct 28.
Vervullens S, Meert L, Smeets RJEM, Verbrugghe J, Baert I, Rahusen FTG, Heusdens CHW, Verdonk P, Meeus M. Preoperative glycaemic control, number of pain locations, structural knee damage, self-reported central sensitisation, satisfaction and personal control are predictive of 1-year postoperative pain, and change in pain from pre- to 1-year posttotal knee arthroplasty. Knee Surg Sports Traumatol Arthrosc. 2025 Jan;33(1):201-219. doi: 10.1002/ksa.12265. Epub 2024 May 15.
Vervullens S, Meert L, Smeets RJEM, Verbrugghe J, Verdonk P, Meeus M. Does pain intensity after total knee arthroplasty depend on somatosensory functioning in knee osteoarthritis patients? A prospective cohort study. Clin Rheumatol. 2024 Jun;43(6):2047-2059. doi: 10.1007/s10067-024-06976-7. Epub 2024 Apr 26.
Other Identifiers
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13/47/472
Identifier Type: -
Identifier Source: org_study_id