Effect of Blood Flow Restriction on Recovery After Maximal Resistance Exercise

NCT ID: NCT07342634

Last Updated: 2026-01-15

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 80 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2026-02-01
• Study Completion Date: 2026-12-31

Brief Summary

Resistance training has been widely performed due to its health benefits. However, performing this training at high intensity causes significant muscle stress, leading to fatigue and compromising performance. It is essential to implement effective recovery strategies to optimize physiological adaptations. Among the accessible techniques, blood flow restriction (BFR) has shown promise for its potential to accelerate muscle recovery.

Detailed Description

A randomized clinical trial will be conducted with 40 men and 40 women allocated to one of four groups: i) BFR using 80% of total occlusion pressure (TOP) [BFR-80%]; ii) BFR using 60% of total occlusion pressure (TOP) [BFR-60%]; iii) BFR using 10 mmHg (BFR-10 mmHg); and iv) control (CON). All groups will undergo initial assessments, followed by the muscle stress protocol, and all outcomes will be collected again. Subsequently, the intervention to which they were previously randomized will be performed, and finally, subsequent assessments will be conducted immediately, 24, 48, and 72 hours after exercise. The outcomes assessed will be, in order: pain using the Numerical Rating Scale (NRS), perception of recovery and discomfort using the Likert scale, and perception of effort using the Borg scale (CR-10), cellular integrity vectors using bioelectrical impedance analysis (BIA), pain threshold using a pressure algometer, muscle tone, stiffness, and elasticity using myotonometry, quadriceps muscle strength test using a digital dynamometer, muscle power test using the Squat Jump test, and a single-leg jump functional test.

Participants will be duly informed about the procedures and objectives of this study, and after agreeing, will sign a free and informed consent form, thus becoming effectively part of it. In the consent form, participants will be asked if they agree to the use of their data should they choose to withdraw from the study. Participants will also be asked for permission for the research team to share relevant data with people from the universities participating in the research or regulatory authorities, when relevant, while preserving the participant's identity. The study will be submitted for review and approval to the Research Ethics Committee of FCT/UNESP, Presidente Prudente, SP, Brazil and will be registered on ClinicalTrials.gov.

Conditions

Recovery; Recovery Time

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

Blood flow restriction with 80% occlusion

Will perform an BFR intervention using 80% of the total occlusion pressure (TOP) continuously for 20 minutes.

Group Type: EXPERIMENTAL

BFR-80%

Intervention Type: DEVICE

Will perform the intervention with BFR using 80% of the total occlusion pressure (TOP) continuously for 20 minutes.

Blood flow restriction with 60% occlusion

Will perform an BFR intervention using 60% of the total occlusion pressure (TOP) continuously for 20 minutes.

Group Type: EXPERIMENTAL

BFR-60%

Intervention Type: DEVICE

Will perform the intervention with BFR using 60% of the total occlusion pressure (TOP) continuously for 20 minutes.

Blood flow restriction with 10 mmHg of occlusion pressure

The intervention will be performed with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes.

Group Type: PLACEBO_COMPARATOR

BFR-10mmHg

Intervention Type: OTHER

Will perform the intervention with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes.

Control

It will remain at rest for 20 minutes without using BFR.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

BFR-80%

Will perform the intervention with BFR using 80% of the total occlusion pressure (TOP) continuously for 20 minutes.

Intervention Type: DEVICE

BFR-60%

Will perform the intervention with BFR using 60% of the total occlusion pressure (TOP) continuously for 20 minutes.

Intervention Type: DEVICE

BFR-10mmHg

Will perform the intervention with BFR using 10 mmHg of occlusion pressure continuously for 20 minutes.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Individuals exhibiting one or more of the following characteristics will not be included:
• (1) diabetes and hypertension;
• (2) inflammatory rheumatological, psychiatric, cardiovascular and/or respiratory disease;
• (3) pre-existing injury restricting their ability to perform vigorous physical activities;
• (4) having one or more predisposing risk factors for thromboembolism.

Exclusion Criteria

• Participants will be excluded from the study if they:
• (1) have a health problem that does not allow them to continue;
• (2) wish to leave the study;
• (3) use medications, electrotherapy, or other therapeutic methods during the study period that could interfere with any results;
• (4) not sign the consent form.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Paulista University

OTHER

Sponsor Role: lead

Responsible Party

Franciele Marques Vanderle

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Franciele Marques Vanderlei

Presidente Prudente, São Paulo, Brazil

Site Status: RECRUITING

Countries

Brazil

Central Contacts

Franciele Marques Vanderlei PhD

Role: CONTACT

franmvanderlei@gmail.com

+55 (18) 3229-5824

Facility Contacts

Franciele M Vanderlei

Role: primary

franmvanderlei@gmail.com

+55 (18) 3229-5824

Other Identifiers

91529125.6.0000.5402

Identifier Type: -

Identifier Source: org_study_id