Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
NCT ID: NCT07325773
Last Updated: 2026-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
104 participants
OBSERVATIONAL
2025-12-01
2026-11-28
Brief Summary
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In this study, patients who receive magnesium sulfate as part of standard anesthetic management will be compared with those who do not receive the drug. Oxygenation parameters, dynamic and static lung mechanics, airway pressures, and ventilation-related indices will be recorded throughout the intraoperative period. The findings of this study may help clarify whether magnesium sulfate provides measurable respiratory benefits during one-lung ventilation.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group 1 - Magnesium Sulfate Group Label: Magnesium Sulfate Group
Patients receiving intravenous magnesium sulfate during the surgery as part of standard anesthetic management.
No interventions assigned to this group
Group 2 - Control Group Label: Control Group
Patients undergoing one-lung ventilation without the administration of magnesium sulfate
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
ASA physical status II-III Ability to provide informed consent Undergoing general anesthesia with double-lumen tube placement
Exclusion Criteria
* Patients with renal, hepatic, or cardiovascular failure
* Patients with a BMI \< 15 kg/m² or \> 35 kg/m²
* Patients with a preoperative pulmonary function test showing FEV₁ \< 1.5 liters
* Patients who are transferred to the intensive care unit intubated in the postoperative period
* Patients with physical or mental conditions that prevent the performance of pulmonary function testing factors
18 Years
80 Years
ALL
No
Sponsors
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Marmara University
OTHER
Responsible Party
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Meliha Orhon
Associate Professor
Principal Investigators
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Meliha ORHON ERGÜN
Role: STUDY_CHAIR
Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation
İlayda AKARSU KAYA
Role: PRINCIPAL_INVESTIGATOR
Marmara University Faculty of Medicine, Department of Anesthesiology and Reanimation
Locations
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Marmara University Faculty of Medicine, Basibuyuk Campus
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
Role: CONTACT
Facility Contacts
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İlayda AKARSU KAYA, Anesthesiology Resident, Principal Investigator
Role: primary
Other Identifiers
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09.2025.463
Identifier Type: -
Identifier Source: org_study_id
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