Ultrasound Guided External Oblique and Rectus Abdominis Plane Block (EXORA) on Neuroendocrine Stress Response in Adults Undergoing Umbilical Hernia Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2026-09-01

Brief Summary

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This study aims to evaluate the efficacy of ultrasound-guided external oblique and rectus abdominis plane block on the neuroendocrine stress response and postoperative analgesia in adults undergoing umbilical hernia repair.

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Detailed Description

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Umbilical hernias of the abdomen are defined as a non-inguinal, non-hiatal defect in the fascia of the abdominal wall. Surgical stress response refers to the physiologic response to surgery and the hormonal and metabolic changes that follow it.

Fascial plane blocks are gaining attention for perioperative analgesia due to their efficacy and safety profiles. The external oblique and rectus abdominis plane (EXORA) block is an emerging technique that provides a sensory block to the anterolateral abdominal wall, potentially filling gaps left by other commonly used blocks, such as the quadratus lumborum (QLB) or erector spinae plane (ESP) blocks.

Conditions

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Ultrasound External Oblique Rectus Abdominis Plane Block Neuroendocrine Stress Response Umbilical Hernia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Group I

Patients will receive general anesthesia only.

Group Type ACTIVE_COMPARATOR

General anesthesia

Intervention Type OTHER

Patients will receive general anesthesia only.

Group Ⅱ

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Group Type EXPERIMENTAL

External oblique and rectus abdominis plane (EXORA) block

Intervention Type OTHER

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Interventions

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General anesthesia

Patients will receive general anesthesia only.

Intervention Type OTHER

External oblique and rectus abdominis plane (EXORA) block

Patients will receive general anesthesia and an external oblique and rectus abdominis plane (EXORA) block with 0.25% bupivacaine.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged from 21 to 65 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) Physical status I and Ⅱ.
* Schedule for elective umbilical hernia surgery under general anesthesia.

Exclusion Criteria

* ASA Ⅲ or Ⅳ.
* Patients with metabolic abnormalities, e.g., diabetes mellitus.
* Patients receiving corticosteroids.
* History of allergies to local anesthetics.
* Bleeding or coagulation disorders.
* Anatomical abnormalities.
* Psychiatric and neurological disorders.
* Complicated hernial defect (obstructed).
* Patient refusal.

Minimum Eligible Age

21 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No