Postoperative Frailty Trajectories and One-Year Mortality in Older Surgical Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

4417 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-01

Study Completion Date

2023-04-30

Brief Summary

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Frailty is a key predictor of adverse outcomes in older surgical patients, yet its longitudinal evolution and potentially reversible nature remain underexplored in perioperative settings. This study aimed to characterize postoperative frailty trajectories in older patients and to examine their association with one-year mortality, as well as factors influencing trajectory group.

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Detailed Description

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Conditions

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Frailty in Older Adults All Cause Mortality Trajectory

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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A retrospective cohort study based on prospectively collected data.

Patients' frailty was assessed using the FRAIL scale at four time points: preoperatively and at 1, 3, and 6 months postoperatively. Patients were classified into distinct frailty trajectory groups using latent class trajectory modeling. The study examined the associations between frailty trajectories and one-year mortality and further identified independent factors associated with frailty trajectory membership.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Aged ≥65 years;
* Underwent elective non-cardiac, non-neurosurgical procedures;
* Completed standardized frailty assessments both preoperatively and postoperatively.

Exclusion Criteria

* Severe dementia, language disorders, significant hearing or visual impairments, or coma;
* Cognitive function below the Mini-Mental State Examination (MMSE) thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher);
* Surgery performed under local anesthesia or monitored anesthesia care;
* Surgical duration ≤30 minutes;
* Missing data on postoperative complications or one-year mortality required for this study;
* Incomplete frailty assessments at 1, 3, and 6 months after surgery.

Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No