Hospital Ederly Life Program for Surgical Patients

NCT ID: NCT03792373

Last Updated: 2019-01-03

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 300 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-12-01
• Study Completion Date: 2019-12-30

Brief Summary

Frailty is the clinically recognizable medical condition, also called syndrome or phenotype, that is, the result of processes leading to an increased vulnerability for serious deteriorations in health and the diminished ability to cope with physical stressors. Recently, frailty has emerged as a significant risk factor for adverse postoperative outcomes. It is related to declines in energy, strength, and function as well as to an increased inflammatory state, including elevated levels of interleukin 6 (IL-6), C-reactive protein (CRP), and anelevated white blood cell count . Frailty, as defined Frailty, as defined in the landmark paper by Fried, included at least three of five of the following criteria: unintentional loss of weight, low physical activity, low energy, low grip strength, and a slowed walking speed. Since then, various frailty scoring lists have been designed to optimize the predictive value. One of these is the Edmonton Frail Scale (EFS), an instrument that can be assessed quickly, using only a simple questionnaire which usually does not require more than five minutes to be completed and which covers most domains of functioning, making it easy and fast to get a reliable impression of the degree of frailty.The aim of this study was to determine which factors,with emphasis on frailty, significantly influence postoperative outcome after elective noncardiac surgery as measured by the Comprehensive Complication Index (CCI).

Conditions

To Investigate the Mortality of the Frailty Patients

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

frailty

No interventions assigned to this group

nonfrailty

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• elective noncardiac surgery

Exclusion Criteria

• patients who don't cooperate

• Minimum Eligible Age: 65 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Zhongda Hospital

OTHER

Sponsor Role: lead

Responsible Party

Jian-jun Yang

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Gaojun Teng, PhD

Role: STUDY_CHAIR

Zhongda Hospital

Locations

Zhongda Hospital

Nanjing, Jiangsu, China

Site Status: RECRUITING

Countries

China

Central Contacts

Xiaoyun Sun, Master

Role: CONTACT

977988901@qq.com

18752009886

Facility Contacts

Yang Jian-jun

Role: primary

yjyangjj@126.com

13357739238

References

Mao M, Wang LY, Zhu LY, Wang F, Ding Y, Tong JH, Sun J, Sun Q, Ji MH. Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients. BMC Geriatr. 2022 Aug 19;22(1):685. doi: 10.1186/s12877-022-03367-y.

Reference Type: DERIVED

PMID: 35982410 (View on PubMed)

Other Identifiers

HELP

Identifier Type: -

Identifier Source: org_study_id