Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aortic Dissection
NCT ID: NCT07315178
Last Updated: 2026-01-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
400 participants
INTERVENTIONAL
2025-11-25
2031-11-30
Brief Summary
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There are two types of dissection: type A, which affects the ascending aorta, and type B, which affects the descending aorta. Type A aortic dissection is almost always a surgical emergency and involves replacing the ascending aorta with a prosthesis. After this type of dissection, a residual dissection remains in the descending aorta, known as residual type B dissection, which becomes chronic. This requires increased monitoring by MRI or CT scan, which are currently not effective enough to predict the development of an aneurysm that could lead to aortic rupture requiring surgical intervention. Other factors such as blood flow, the forces and mechanisms regulating blood circulation, the mechanics and histology of the aorta, and blood markers could provide a more reliable prediction of the development of an aneurysm. The creation of a digital twin model incorporating all these factors should enable better patient management.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Type B aortic dissection
MRI with 4D flow imaging
At 3 months
blood sampling
2 tubes of 10 ml blood at inclusion, at 3 months, at 12 months, at 24 months and at 36 months
Residual type B aortic dissection following surgery for type A aortic dissection
MRI with 4D flow imaging
At 3 months
blood sampling
2 tubes of 10 ml blood at inclusion, at 3 months, at 12 months, at 24 months and at 36 months
Interventions
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MRI with 4D flow imaging
At 3 months
blood sampling
2 tubes of 10 ml blood at inclusion, at 3 months, at 12 months, at 24 months and at 36 months
Eligibility Criteria
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Inclusion Criteria
* Age \> 18 years
* Patient with type A aortic dissection with surgical indication for replacement
* Patient with chronic type B aortic dissection, monitored and managed medically, not operated on
Exclusion Criteria
* Persons subject to legal protection measures (guardianship)
* Persons subject to judicial protection measures
* Pregnant women, women in labour or breastfeeding
* Adults who are incapacitated or unable to give their consent
* Contraindications to MRI: claustrophobia, non-MRI-compatible metal implants, suspected metal foreign body
* Severe renal failure (clearance \<30ml/min according to Cockroft due to gadolinium injection)
* Uncontrolled asthma
* Patients with acute type A aortic dissection who died during or in the post-operative period following surgery to repair the dissection
* Patients with a known allergy to gadolinium-based contrast agents
* Patients treated for type B aortic dissection who underwent surgery
18 Years
ALL
No
Sponsors
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Centre Hospitalier Universitaire Dijon
OTHER
Responsible Party
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Locations
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Chu Dijon Bourgogne
Dijon, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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BOUCHOT FEDER 2024
Identifier Type: -
Identifier Source: org_study_id
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