Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction
NCT ID: NCT02789098
Last Updated: 2022-03-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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SUSPENDED
NA
30 participants
INTERVENTIONAL
2016-06-30
2023-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
OTHER
NONE
Study Groups
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STEMI
All patients included in this study (1 arm)
(15)-O water positron emission tomography and Biomarkers
Coronary endothelial function is assessed using (15)-O water positron emission tomography and cold pressor test . The response to the test is defined by the percentage increase myocardial blood flow . Assessment of fibrosis, inflammation an endothelial function is performed using biomarkers.
Interventions
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(15)-O water positron emission tomography and Biomarkers
Coronary endothelial function is assessed using (15)-O water positron emission tomography and cold pressor test . The response to the test is defined by the percentage increase myocardial blood flow . Assessment of fibrosis, inflammation an endothelial function is performed using biomarkers.
Eligibility Criteria
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Inclusion Criteria
* Primary Percutaneous Coronary Intervention (TIMI 3)
* Single vessel coronary artery disease
* Age over 18 years
* Informed Consent dated and signed
* Written and spoken French
* Beneficiary of social security insurance
Exclusion Criteria
* TIMI 0-2 after Primary Percutaneous Coronary Intervention
* Significant two or three-vessel coronary artery disease (\> 70% stenosis in at least one of the other two coronary arteries)
* Past history of myocardial infarction before STEMI
* Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure
* Pregnant and / or lactating
* Age under 18 years or guardianship
18 Years
ALL
No
Sponsors
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Société Française de Cardiologie
OTHER
University Hospital, Caen
OTHER
Responsible Party
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Principal Investigators
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Farzin GF BEYGUI, PhD
Role: STUDY_CHAIR
CHU CAEN
Alain MA Manrique, PhD
Role: STUDY_CHAIR
CHU CAEN
Locations
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CHu de Caen
Caen, Normandy, France
Countries
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Other Identifiers
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2015-A01650-49
Identifier Type: -
Identifier Source: org_study_id
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