Evaluation of the PERC Score and the YEARS Algorithm in the Diagnosis of Pulmonary Embolism in the Emergency Department

NCT ID: NCT07313501

Last Updated: 2026-01-02

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 500 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-02-26
• Study Completion Date: 2026-02-28

Brief Summary

The current diagnostic strategy for pulmonary embolism relies on clinical evaluation, followed by D-dimer testing and chest CT angiography. However, this approach leads to overuse of CT angiography. Diagnosis remains complex, with nonspecific clinical signs. Recent studies have explored new algorithms, such as the YEARS algorithm and the PERC score, which aim to support the diagnosis and reduce the need for imaging examinations. Their use could decrease waiting times in the emergency department and limit the need for additional investigations.

Conditions

Pulmonary Embolism

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Adult patient (≥18 years)
• Patient admitted to the adult emergency department of the Strasbourg University Hospital over a 6-month period (January to June 2024), for whom a D-dimer test and chest imaging (thoracic CT angiography or ventilation/perfusion scintigraphy) were performed

Exclusion Criteria

• No D-dimer test or test performed for another indication, no chest imaging (CT angiography or scintigraphy), long-term anticoagulant treatment.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Service d'Urgences Médico-Chirurgicales Adules - CHU de Strasbourg - France

Strasbourg, , France

Site Status: RECRUITING

Countries

France

Central Contacts

François WEILL, MD

Role: CONTACT

francois.weill@chru-strasbourg.fr

33 3.88.11.54.67

Facility Contacts

François WEILL, MD

Role: primary

francois.weill@chru-strasbourg.fr

33 3.88.11.54.67

Other Identifiers

9611

Identifier Type: -

Identifier Source: org_study_id