Action Outcome Latencies as a Measure of Sense of Agency in Functional Movement Disorders.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-31

Study Completion Date

2028-01-31

Brief Summary

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Functional movement disorders (FMD) are among the most common neurological conditions seen in clinical practice, yet they are poorly understood and often misdiagnosed. Impaired self-agency, the sense of controlling one's actions, is a key feature of FMD. Studies using functional MRI have shown reduced activation and connectivity in the right inferior parietal lobule, a region associated with agency.

The sense of agency consists of two components: the feeling of agency, which is an implicit, low-level sense of control over voluntary actions, and the judgment of agency, which is the conscious attribution of actions to oneself. While the feeling of agency is often measured using intentional binding tasks, judgment of agency is assessed using self-reported scales. While studies have explored intentional binding as a measure of implicit agency in FMD, few have systematically investigated judgment of agency. This study aims to fill this gap by introducing a novel approach that quantitatively evaluates judgment of agency in FMD patients using action-outcome latencies as an objective metric.

Detailed Description

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Objective: The objective of this study is to investigate the differences between patients with FMD and healthy controls in perceiving visual and auditory outcomes as consequences of their actions. This will be assessed by measuring their judgment of agency through action-outcome latencies.

Conditions

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Functional Movement Disorder

Keywords

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functional movement disorder sense of agency judgment of agency

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cases

Functional Movement Disorder

No interventions assigned to this group

Controls

Healthy subjects

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Inclusion criteria for patients: Inclusion criteria for patients: (1) Diagnosed with clinically definite functional movement disorders as per the criteria established by Lang et al. (2) Age \>18 years. (3) Able to read and understand English.

Inclusion criteria for healthy subjects: (1) Age \>18 years. (2) Able to read and understand English

Exclusion criteria for patients: (1) Moderate to severe action tremor in the dominant hand limiting the ability to perform the task. (2) Upper limb peripheral neuropathy. (3) Unable to read and understand English.

Exclusion criteria for healthy subjects: (1) Moderate to severe action tremor in the dominant hand limiting the ability to perform the task. (2) Upper limb peripheral neuropathy. (3) Unable to read and understand English.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Aditya Murgai

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University Hospital

London, Ontario, Canada

Site Status

Countries

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Canada

Central Contacts

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Aditya Murgai, MBBS MD DM

Role: CONTACT

Phone: 15196633121

Email: [email protected]

Other Identifiers

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