COMPARISON OF MEAN DURATION OF POST OPERATIVE ANALGESIA FOLLOWING ADDITION OF DEXMEDETOMIDINE TO ROPIVACAINE VERSUS PLAIN ROPIVACAINE ON ULTRASOUND GUIDED RECTUS SHEATH BLOCK

NCT ID: NCT07254130

Last Updated: 2025-11-28

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 209 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2025-09-20

Brief Summary

To compare the mean duration of postoperative analgesia following addition of dexmedetomidine to ropivacaine versus plain ropivacaine in ultrasound guided rectus sheath block in patients undergoing midline laparotomies

Conditions

Midline Laparotomy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Ropivacaine only group

Group Type: ACTIVE_COMPARATOR

Rectus Sheath Block

Intervention Type: PROCEDURE

In Dexmedetomedine combined with ropivacaine group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine mixed with 1ug/kg body weight will be injected to hydrodissect the rectus muscle from the posterior sheath.

In ropivacine only group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine will be injected to hydrodissect the rectus muscle from the posterior sheath.

Dexmedetomedine combined with ropivacaine group

Group Type: ACTIVE_COMPARATOR

Rectus Sheath Block

Intervention Type: PROCEDURE

In Dexmedetomedine combined with ropivacaine group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine mixed with 1ug/kg body weight will be injected to hydrodissect the rectus muscle from the posterior sheath.

In ropivacine only group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine will be injected to hydrodissect the rectus muscle from the posterior sheath.

Interventions

Rectus Sheath Block

In Dexmedetomedine combined with ropivacaine group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine mixed with 1ug/kg body weight will be injected to hydrodissect the rectus muscle from the posterior sheath.

In ropivacine only group, under ultrasound guidance, the needle will be advanced posterior to the rectus muscle, and 20 ml of 0.25% ropivacaine will be injected to hydrodissect the rectus muscle from the posterior sheath.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

Patients with age 30 - 60 years.

• Patients that will be scheduled for laparotomy under general anesthesia.
• ASA (American Society of Anesthesiologist) s

Exclusion Criteria

• Patient who will refuse for participation in study.
• Infection at site of Rectus Sheath block.
• History of any addiction.
• Sensitivity to the local anesthetics.
• Patient with pre-existing coagulation abnormalities INR more than 1.5.

• Minimum Eligible Age: 30 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Quaid-e-Azam Medical College

OTHER

Sponsor Role: lead

Responsible Party

Anam Mahmood

Principal investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Bahawal Victoria Hospital, Bahawalpur

Bahawalpur, Punjab Province, Pakistan

Countries

Pakistan

Other Identifiers

BVH-2025-CT-012

Identifier Type: -

Identifier Source: org_study_id