tACS Modulates Speech and Cognitive Impairments in People With PD by Targeting the Medial Frontal Cortex
NCT ID: NCT07240272
Last Updated: 2025-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
28 participants
INTERVENTIONAL
2023-08-01
2025-08-01
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
1. Can tACS stimulation of the MFC improve executive functions in people with PD (such as reasoning, planning, inhibition, and complex problem-solving)?
2. Can it improve the integration of auditory information and speech motor control during communication?
Researchers will compare the effects of real tACS versus sham (placebo) stimulation to see if real stimulation leads to better speech and cognitive outcomes in PD patients.
Participants will:
1. Receive one extra 20-minute session of either real or sham tACS each day for two weeks
2. Attend clinic visits before stimulation, right after the 2-week period, and again at 1 month and 3 months for assessments and tests
3. Have their executive function scores, speech performance, and related brain activity recorded
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Transcranial Direct/ Alternating Current Stimulation for Parkinson's Disease Treatment
NCT05678725
The Impact TDCS-linked Motor and Cognitive Training Gains in Parkinson's Disease
NCT04581590
Multifocal Neuromodulation in Motor and Cognitive Function of People With Parkinson's Disease
NCT04090385
The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
NCT02656316
Transcranial Direct Current Stimulation for Motor Function and Fatigue in PD
NCT06883266
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
6Hz-group
6Hz-tACS
tACS applied to the MFC at a frequency of 6 Hz, using a high-definition 1×4 electrode configuration with individualized current intensity, delivered for 20 minutes.
Sham-group
Sham-tACS
Except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in 6Hz-group.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
6Hz-tACS
tACS applied to the MFC at a frequency of 6 Hz, using a high-definition 1×4 electrode configuration with individualized current intensity, delivered for 20 minutes.
Sham-tACS
Except for turning down the current intensity to zero during the 20-minute period, all other parameters are identical to those in 6Hz-group.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
2. Aged 35-80 years.
3. Absence of non-PD neurological disorders.
4. No hearing impairment, dementia, psychiatric abnormalities, or history of neurosurgical treatment.
Exclusion Criteria
2. Any contraindications to electrical stimulation.
35 Years
80 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
Ke Dong, MD
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Ke Dong, MD
Research Associate
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
Nos.82172528
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.